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Specialty: Epidemiology

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Total 51 results found since Jan 2013.

EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
Conclusions: The PEI nanocomplex fabricated with EpApt and siEp was able to target EpCAM tumor cells, deliver the siRNA and silence the target gene. This nanocomplex exhibited decreased cell proliferation than the scrambled aptamer loaded nanocomplex in the EpCAM expressing cancer cells and may have potential for EpCAM targeting in vivo.
Source: Epidemiologic Perspectives and Innovations - January 9, 2015 Category: Epidemiology Authors: Nithya SubramanianJagat R KanwarPrasanna AthalyaNarayanan JanakiramanVikas KhetanRupinder K KanwarSailaja EluchuriSubramanian Krishnakumar Source Type: research

Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells
Adv Healthc Mater. 2023 Jan 8:e2202670. doi: 10.1002/adhm.202202670. Online ahead of print.ABSTRACTHepatic clearance of lipid nanoparticles (LNP) with encapsulated nucleic acids restricts their therapeutic applicability. Therefore, tools for regulating hepatic clearance are of high interest for nucleic acid delivery. To this end, this work employs wild-type (WT) and low-density lipoprotein receptor (Ldlr)-/- mice pretreated with either a leukotriene B4 receptor inhibitor (BLT1i) or a high-density lipoprotein receptor inhibitor (HDLRi) prior to the injection of siRNA-LNP. This work is able to demonstrate significantly incre...
Source: Adv Data - January 8, 2023 Category: Epidemiology Authors: Cheng Lin Asmaa Mostafa Alexander Jans Justina Clarinda Wolters Mohamed Ramadan Mohamed Emiel P C Van der Vorst Christian Trautwein Matthias Bartneck Source Type: research

Nanoneedles Induce Targeted siRNA  Silencing of p16 in the Human Corneal Endothelium
Adv Sci (Weinh). 2022 Oct 17:e2203257. doi: 10.1002/advs.202203257. Online ahead of print.ABSTRACTNanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle-mediated RNA interference therapy aimed at enhancing its proliferative capacity, necessary for tissue regeneration. This work develops a strategy for siRNA nanoninjection to the human corneal endothelium. Nanoneedles can deliver p16-targeting siRNA to primary human corneal endothelial cells in vitro without toxicity. The nanoinjection of ...
Source: Adv Data - October 17, 2022 Category: Epidemiology Authors: Eleonora Maurizi Davide Alessandro Martella Davide Schiroli Alessia Merra Salman Ahmad Mustfa Graziella Pellegrini Claudio Macaluso Ciro Chiappini Source Type: research

Synergistic inhibition of avian leukosis virus subgroup J replication by miRNA-embedded siRNA interference of double-target
Conclusions: These data demonstrated that the miRNA-embedded siRNA interference is an efficient method for inhibition of ALV-J replication, especially double targets.
Source: Epidemiologic Perspectives and Innovations - March 21, 2015 Category: Epidemiology Authors: Rongrong WeiXiaoqian MaGuihua WangHuijun GuoJianzhu LiuLingxiao FanZiqiang Cheng Source Type: research

Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells
Conclusions: These findings strongly suggest that HIF-1α exerts an antiapoptotic role and participates in the downregulation of GR by dexamethasone in hypoxic AtT-20 cells.
Source: Epidemiologic Perspectives and Innovations - May 22, 2015 Category: Epidemiology Authors: Chenran ZhangQiang QiangYing JiangLiuhua HuXuehua DingYicheng LuGuohan Hu Source Type: research

CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression
Conclusions: Our results clearly indicate that non-phosphorylated CRTC2 strongly enhances HBV biosynthesis through inducing PGC1alpha expression. Further study of the mechanisms will elucidate the importance of metabolic signals on HBV transcription and replication, and offer insight into potential targets for developing anti-HBV agents.
Source: Epidemiologic Perspectives and Innovations - February 14, 2014 Category: Epidemiology Authors: Xiaohui TianFei ZhaoWeihua SunXiaoguang ZhiZhikui ChengMing ZhouKanghong Hu Source Type: research

Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells
Conclusions: Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action.
Source: Epidemiologic Perspectives and Innovations - March 4, 2014 Category: Epidemiology Authors: Bin PengXue ZhangFanfan CaoYing WangLimin XuLu CaoChunxin YangMaoquan LiGeorges UzanDenghai Zhang Source Type: research

Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer
Conclusions: Our approach has identified genes required for the migration and invasion of metastatic tumor cells, and we propose that our new in vivo model system will be a powerful tool to interrogate the metastatic cascade in prostate cancer.
Source: Epidemiologic Perspectives and Innovations - May 30, 2014 Category: Epidemiology Authors: Jacqueline BanyardIvy ChungMatthew MigliozziDerek T PhanArianne M WilsonBruce R ZetterDiane R Bielenberg Source Type: research

Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
Conclusions: Deregulation of HDAC8 is frequent in urothelial cancer, but neither specific pharmacological inhibition nor siRNA-mediated knockdown of HDAC8 impaired viability of urothelial cancer cell lines in a therapeutic useful manner. Accordingly, HDAC8 on its own is not a promising drug target in bladder cancer.
Source: Epidemiologic Perspectives and Innovations - July 10, 2014 Category: Epidemiology Authors: Maria LehmannMichèle J HoffmannAnnemarie KochScott M UlrichWolfgang A SchulzGünter Niegisch Source Type: research

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation.
CONCLUSION: In previous studies, a network of stoichiometric equations was modeled. However, in this particular study, we modeled the mechanism behind the silencing process. Modeling this kind of mechanisms provides us with a tool to examine the effects of different factors such as mutation or drugs on the process. PMID: 27376039 [PubMed]
Source: Adv Data - July 6, 2016 Category: Epidemiology Authors: Nickaeen N, Moein S, Heidary Z, Ghaisari J Tags: Adv Biomed Res Source Type: research

pH-sensitive, tail-modified, ester-linked ionizable cationic lipids for gene delivery
Biomater Adv. 2022 Jun 14;139:212984. doi: 10.1016/j.bioadv.2022.212984. Online ahead of print.ABSTRACTIonizable cationic lipids have great potential for gene delivery, yet the effect of the molecular structure of such lipids on gene delivery efficiency is an ongoing research challenge. To better understand corresponding structure-function activity relationships, we synthesized four ester-linked, pH-responsive, ionizable cationic lipids. The screened DEDM4 lipid, containing 2-ethylenedimethylamine in the headgroup and a branched-chain tail, exhibited a high delivery efficacy of plasmid DNA and siRNA in A549 cells, which wa...
Source: Adv Data - July 26, 2022 Category: Epidemiology Authors: Yu Zou Yuhong Zhen Yinan Zhao Huiying Chen Rui Wang Wei Wang Pengfei Ma Defu Zhi Benzhi Ju Shubiao Zhang Source Type: research

Effect of the array of amines on the transfection efficiency of cationic peptidomimetic lipid molecules into neural cells
RSC Adv. 2022 Aug 3;12(33):21567-21573. doi: 10.1039/d2ra03347j. eCollection 2022 Jul 21.ABSTRACTThe amino groups in the head group of a cationic lipid play a determinative role regarding the nucleic acid delivery efficiency of the LNP formulated from lipids. Herein, we designed four types of lipid bearing different amine-containing branched head groups to investigate the influence of type and number of amines on the neural cell targeted nuclei acid delivery. Conjugation of an ethylamino group at selected positions of a lysine-based cationic lipid resulted in 4 distinct lipids with 3 (denoted N3 lipid), 4 (denoted N4 lipid...
Source: Adv Data - August 17, 2022 Category: Epidemiology Authors: Xiang Yu Hai Xiao Muqier Muqier Shuqin Han Huricha Baigude Source Type: research

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
Conclusions: Our results suggest that the extracts of this polyherbal combination increase histone 3 acetylation, inhibit the expression of class I and class II histone deacetylases, increase the activation of CBP/p300 and inhibit cell proliferation, in part, by up regulating p21 expression.
Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: E-Chu HuangYi ZhaoGuoxun ChenSeung Joon BaekMichael F McEnteeSteven MinkinJohn P BiggerstaffJay Whelan Source Type: research

Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells
Conclusions: Our results suggest that olaparib, a PARP inhibitor, is effective on certain endometrial cancer cell lines. Inactivation of PTEN might not affect the DNA repair function. Predictive biomarkers are warranted to utilize olaparib in endometrial cancer.
Source: Epidemiologic Perspectives and Innovations - March 13, 2014 Category: Epidemiology Authors: Aki MiyasakaKatsutoshi OdaYuji IkedaOsamu Wada-HiraikeTomoko KashiyamaAtsushi EnomotoNoriko HosoyaTakahiro KosoTomohiko FukudaKanako InabaKenbun SoneYuriko UeharaReiko KurikawaKazunori NagasakaYoko MatsumotoTakahide ArimotoShunsuke NakagawaHiroyuki Kuramo Source Type: research