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Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells
Conclusions: Our results indicate that reduced expression of the nuclear long noncoding RNA NEAT1 may play a role in the myeloid differentiation of APL cells.
Source: Epidemiologic Perspectives and Innovations - September 23, 2014 Category: Epidemiology Authors: Chengwu ZengYan XuLing XuXibao YuJingjing ChengLijian YangShaohua ChenYangqiu Li Source Type: research

Characterization of beta2-microglobulin expression in different types of breast cancer
Background: Betaeta-2-microglobulin (beta2-M) has been demonstrated as a growth factor and signaling molecule in breast cancer and leukemia. The purpose of the study is to characterize beta2-M expression in molecular subtypes of breast cancer, thereby investigating the mechanism of beta2-M action in breast cancer. Methods: beta2-M and B-Cell Lymphoma/Leukemia 2 (Bcl-2) transcript expression levels in breast cancer tissue and the corresponding normal tissue were quantified using real-time PCR. The protein expression levels of beta2-M, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor...
Source: Epidemiologic Perspectives and Innovations - October 7, 2014 Category: Epidemiology Authors: Kesheng LiHuifen DuXiaowen LianSuisheng YangDandan ChaiChunya WangRong YangXuezhong Chen Source Type: research

Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocyte
Conclusions: Mitochondrial Ca2+ uptake is a key event in insulin signaling and metabolism in cardiomyocytes.
Source: Epidemiologic Perspectives and Innovations - November 7, 2014 Category: Epidemiology Authors: Tomas GutierrezValentina ParraRodrigo TroncosoChristian PennanenAriel Contreras-FerratCésar Vasquez-TrincadoPablo E MoralesCamila Lopez-CrisostoCristian Sotomayor-FloresMario ChiongBeverly A RothermelSergio Lavandero Source Type: research

DEK is a potential marker for aggressive phenotype and irinotecan-based therapy response in metastatic colorectal cancer
Conclusions: These data suggest DEK overexpression as a crucial event for the emergence of an aggressive phenotype in colorectal cancer and its potential role as biomarker for irinotecan response in those patients with KRAS wild-type status.
Source: Epidemiologic Perspectives and Innovations - December 16, 2014 Category: Epidemiology Authors: Javier Martinez-UserosMaria Rodriguez-RemirezAurea Borrero-PalaciosIrene MorenoArancha CebrianTeresa Gomez del PulgarLaura del Puerto-NevadoRicardo Vega-BravoAlberto Puime-OtinNuria PerezSandra ZazoClara SeninMaria J Fernandez-AceñeroMaria S SoengasFeder Source Type: research

Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells
Conclusions: The anti-MTB effects of IL-32γ are mediated through classical caspase-3-dependent apoptosis as well as caspase-3-independent apoptosis.
Source: Epidemiologic Perspectives and Innovations - February 21, 2015 Category: Epidemiology Authors: Xiyuan BaiWilliam H KinneyWen-Lin SuAn BaiAlida R OvrutskyJennifer R HondaMihai G NeteaMarcela Henao-TamayoDiane J OrdwayCharles A DinarelloEdward D Chan Source Type: research

Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPK¿ and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
Conclusion: Collectively, our results show that baicalein inhibits growth and induces apoptosis of NSCLC cells through AMPKα- and MEK/ERK1/2-mediated increase and interaction of FOXO3a and RUNX3 protein. The crosstalk between AMPKα and MEK/ERK1/2 signaling pathways, and the reciprocal interplay of FOXO3a and RUNX3 converge on the overall response of baicalein. This study reveals a novel mechanism for regulating FOXO3a and RUNX3 signaling axis in response to baicalein and suggests a new strategy for NSCLC associated targeted therapy.
Source: Epidemiologic Perspectives and Innovations - May 6, 2015 Category: Epidemiology Authors: Fang ZhengJingjing WuShunyu ZhaoQingmei LuoQing TangLiJun YangLiuning LiWanYing WuSwei Hann Source Type: research

ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis
Conclusions: Thus, salinomycin mainly induces programmed necrosis in cultured glioma cells.
Source: Epidemiologic Perspectives and Innovations - May 29, 2015 Category: Epidemiology Authors: Li-sen QinPi-feng JiaZhi-qing ZhangShi-ming Zhang Source Type: research

Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections
Conclusion: We have found that Sam68 is a specific binding partner for FMDV non-structural proteins 3C pro and 3D pol and showed that mutations at RAAA motifs in IRES domains 3 and 4 cause a decrease in Sam68 affinity to these RNA elements and rendered the mutant RNA non-viable. Interestingly, in FMDV infected cells re-localized Sam68 was transiently detected along with SG markers in the cytoplasm. These results support the importance of Sam68 as a host factor co-opted by FMDV during infection and demonstrate that Sam68 interact with both, FMDV RNA motifs in the IRES and viral no...
Source: Epidemiologic Perspectives and Innovations - December 23, 2015 Category: Epidemiology Authors: Devendra RaiPaul LawrenceAnna KlocElizabeth SchaferElizabeth Rieder Source Type: research

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro
Conclusions: These findings implicate microglia-derived TNFα as a mediator of nPM in air pollution-associated neurodegenerative changes which alter synaptic functions and neuronal growth.
Source: Epidemiologic Perspectives and Innovations - January 26, 2016 Category: Epidemiology Authors: Hank ChengDavid DavisSina HasheminassabConstantinos SioutasTodd MorganCaleb Finch Source Type: research

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug
Conclusions: Cumulatively, these results signify a crucial role of the anti-inflammatory agent aspirin as a novel negative regulator of epithelial-to-mesenchymal transition thereby suggesting its candidature as a promising tool for deterring metastasis of highly invasive K-ras-expressing NSCLC cells.
Source: Epidemiologic Perspectives and Innovations - January 26, 2016 Category: Epidemiology Authors: Poulami KhanArgha MannaShilpi SahaSuchismita MohantyShravanti MukherjeeMinakshi MazumdarDeblina GuhaTanya Das Source Type: research

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
Conclusions: Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Katherine WoodsAshley J. KnightsMatthew AnakaRalf SchittenhelmAnthony PurcellAndreas BehrenJonathan Cebon Source Type: research

Unsaturated, Trialkyl Ionizable Lipids are Versatile LNP Components for Therapeutic and Vaccine Applications
This article is protected by copyright. All rights reserved.PMID:36680477 | DOI:10.1002/adma.202209624
Source: Adv Data - January 21, 2023 Category: Epidemiology Authors: Kieu Lam Ada Leung Alan Martin Mark Wood Petra Schreiner Lorne Palmer Owen Daly Wenchen Zhao Kevin McClintock James Heyes Source Type: research

Enhancing the Management of Metastatic Tumors by Robust Co-delivery of 5-fluorouracil/microRNA-10b inhibitor Using EGFR-targeted Nanovehicles
This article is protected by copyright. All rights reserved.PMID:36740892 | DOI:10.1002/adhm.202202989
Source: Adv Data - February 6, 2023 Category: Epidemiology Authors: Di Wang Liwei Wang Liming Zheng Jiaxin Chen Wei Zhang Wei Zhou Xiaobo Yang Lifeng Jiang Xiaoqiang Jin Xiaohua Yu Xin Liu Heng Chen Jianbin Xu Source Type: research

Optimizing Lipid Nanoparticles for Delivery in Primates
This article is protected by copyright. All rights reserved.PMID:36972555 | DOI:10.1002/adma.202211420
Source: Adv Data - March 27, 2023 Category: Epidemiology Authors: Kieu Lam Petra Schreiner Ada Leung Paul Stainton Steve Reid Ed Yaworski Pete Lutwyche James Heyes Source Type: research

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