Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells

Conclusions:
Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action.

Source: Epidemiologic Perspectives and Innovations - March 4, 2014 Category: Epidemiology Authors: Bin PengXue ZhangFanfan CaoYing WangLimin XuLu CaoChunxin YangMaoquan LiGeorges UzanDenghai Zhang Source Type: research