CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression

Conclusions:
Our results clearly indicate that non-phosphorylated CRTC2 strongly enhances HBV biosynthesis through inducing PGC1alpha expression. Further study of the mechanisms will elucidate the importance of metabolic signals on HBV transcription and replication, and offer insight into potential targets for developing anti-HBV agents.

Source: Epidemiologic Perspectives and Innovations - February 14, 2014 Category: Epidemiology Authors: Xiaohui TianFei ZhaoWeihua SunXiaoguang ZhiZhikui ChengMing ZhouKanghong Hu Source Type: research