TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness

Conclusion:
The present study reports an involvement of miR-93-mediated TGFbetaR2 down-regulation in NPC aggressiveness, thus giving extended insights into molecular mechanisms underlying cancer aggressiveness. Approaches aimed at blocking miR-93 may serve as a promising therapeutic strategy for treating NPC patients.

Source: Epidemiologic Perspectives and Innovations - March 8, 2014 Category: Epidemiology Authors: Xiaoming LyuWeiyi FangHang ZhengLongmei CaiYanfen YeLan ZhangJinbang liHong PengWilliam C ChoEna WangFrancesco M MarincolaKaitai YaoHongbing CaiJiliang LiXin Li Source Type: research