• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma
CONCLUSIONS: The present study confirms over-expression of CA9 in UC and for the first time shows a correlation with molecular subtypes. However, CA9 expression showed no association with the outcome of patients with muscle invasive bladder cancer and inhibition of CA9 did not lead to a consistent inhibition of tumor growth. Based on these data, CA9 exhibits a role neither as a predictive or prognostic marker nor as a therapeutic target in invasive UC.PMID:34083096 | DOI:10.1016/j.urolonc.2021.04.011
Source: Urologic Oncology - June 4, 2021 Category: Urology & Nephrology Authors: Tilman Todenh öfer Ewan A Gibb Roland Seiler Alireza Kamyabi J örg Hennenlotter Paul McDonald Igor Moskalev Craig Stewart Jian Gao Ladan Fazli Shoukat Dedhar Arnulf Stenzl Htoo Zarni Oo Peter C Black Source Type: research

The contrasting roles of Dysferlin during tumor progression in renal cell carcinoma.
CONCLUSION: DYSF mRNA and protein expression are opposingly involved in tumor progression of ccRCC. DYSF could be used as a prognostic biomarker to predict survival of patients with ccRCC. PMID: 32430251 [PubMed - as supplied by publisher]
Source: Urologic Oncology - May 16, 2020 Category: Urology & Nephrology Authors: Cox A, Zhao C, Tolkach Y, Nettersheim D, Schmidt D, Kristiansen G, Hauser S, Müller SC, Ritter M, Ellinger J Tags: Urol Oncol Source Type: research

lncRNA CCAT1 promotes bladder cancer cell proliferation, migration and invasion
Conclusion: CCAT1 plays an oncogenic role in urothelial carcinoma of the bladder. In addition, CCAT1 may be a potential therapeutic target in this cancer.
Source: International Braz J Urol - June 27, 2019 Category: Urology & Nephrology Source Type: research

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

Inhibition of LDHA Deliver Potential Anticancer Performance in Renal Cell Carcinoma
Conclusions: These findings are consistent with the view that LDHA, as an oncogene, might be a potential therapeutic target in RCC.Urol Int
Source: Urologia Internationalis - March 30, 2016 Category: Urology & Nephrology Source Type: research

The role of NFATc1 in prostate cancer progression: Cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion
CONCLUSIONSOur results suggest that NFATc1 plays an important role in prostate cancer outgrowth. Thus, NFATc1 inactivation, especially using CsA and FK506, has the potential of being a therapeutic approach for not only hormone‐naïve but also castration‐resistant prostate cancers. Prostate © 2015 Wiley Periodicals, Inc.
Source: The Prostate - January 29, 2015 Category: Urology & Nephrology Authors: Takashi Kawahara, Eiji Kashiwagi, Hiroki Ide, Yi Li, Yichun Zheng, Hitoshi Ishiguro, Hiroshi Miyamoto Tags: Original Article Source Type: research

Phosphorylated p70S6K in noninvasive low-grade urothelial carcinoma of the bladder: correlation with tumor recurrence.
Abstract We investigated whether inhibiting phosphorylated p70S6K (p-p70S6K) suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma (LG-URCa) in vitroand whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray (TMA) for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70S6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effe...
Source: Asian Journal of Andrology - March 11, 2014 Category: Urology & Nephrology Authors: Kim SJ, Kim JH, Jung HS, Lee TJ, Lee KM, Chang IH Tags: Asian J Androl Source Type: research

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion.
Abstract SETDB1 has been established as an oncogene in a number of human carcinomas. The present study was to evaluate the expression of SETDB1 in prostate cancer (PCa) tissues and cells and to preliminarily investigate the role of SETDB1 in prostate tumorigenesis in vitro. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were used to detect the expression of SETDB1 in PCa tissues, adjacent normal tissues, benign prostatic hyperplasia (BPH) tissues, PCa cell lines and normal prostate epithelial cells. The results suggested that SETDB1 was upregulated in human PC...
Source: Asian Journal of Andrology - February 18, 2014 Category: Urology & Nephrology Authors: Sun Y, Wei M, Ren SC, Chen R, Xu WD, Wang FB, Lu J, Shen J, Yu YW, Hou JG, Xu CL, Huang JT, Sun YH Tags: Asian J Androl Source Type: research

Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer
Conclusion: These findings suggest that both the mTOR pathway downstream of eukaryotic initiation factor 4E and S6K1 can be successfully inhibited, therefore, the recurrence of bladder cancer can be prevented by high-dose rapamycin only, suggesting that 4E-BP1 might be still under mTORC1.
Source: Urologic Oncology: Seminars and Original Investigations - November 18, 2013 Category: Urology & Nephrology Authors: Jong Kyou Kwon, Soon-Ja Kim, Jung Hoon Kim, Kyung Mee Lee, In Ho Chang Tags: Abstracts for Online Original Articles and Reviews Source Type: research

Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer☆,☆☆?>
CONCLUSION: These findings suggest that both the mTOR pathway downstream of eukaryotic initiation factor 4E and S6K1 can be successfully inhibited, therefore, the recurrence of bladder cancer can be prevented by high-dose rapamycin only, suggesting that 4E-BP1 might be still under mTORC1. PMID: 24239466 [PubMed - as supplied by publisher]
Source: Urologic Oncology - November 13, 2013 Category: Urology & Nephrology Authors: Kyou Kwon J, Kim SJ, Hoon Kim J, Mee Lee K, Ho Chang I Tags: Urol Oncol Source Type: research

The over‐expression of Pim‐2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B
CONCLUSIONPim‐2 was over‐expressed in PCA cell lines and tissues. It may inhibit the apoptosis of PCA cells through phosphorylating eIF4B, thus promote the tumorigenesis of PCA. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 27, 2013 Category: Urology & Nephrology Authors: Ke Ren, Xin Gou, Mingzhao Xiao, Ming Wang, Chaodong Liu, Zhaobing Tang, Weiyang He Tags: Original Article Source Type: research

NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma
Conclusions: Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that NOTCH1 could regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines. These might provide a basis for the designing new therapeutic strategies for CCRCC.
Source: Urologic Oncology: Seminars and Original Investigations - October 13, 2011 Category: Urology & Nephrology Authors: Shangwen Liu, Xin Ma, Qing Ai, Qingbo Huang, Taoping Shi, Mingyang Zhu, Baojun Wang, Xu Zhang Tags: Clinical - Kidney Source Type: research