Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer

Conclusion: These findings suggest that both the mTOR pathway downstream of eukaryotic initiation factor 4E and S6K1 can be successfully inhibited, therefore, the recurrence of bladder cancer can be prevented by high-dose rapamycin only, suggesting that 4E-BP1 might be still under mTORC1.
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Abstracts for Online Original Articles and Reviews Source Type: research