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PPAR γ Mediates Protective Effect against Hepatic Ischemia/Reperfusion Injury via NF-κB Pathway
CONCLUSIONS: PPARγ present protective effects on HIRI by attenuating liver injury, inflammatory response, oxidative stress and apoptosis in vivo and in vitro, and its mechanism may be related to down-regulation of NF-κB signaling.PMID:35732295 | DOI:10.1080/08941939.2022.2090033
Source: Journal of Investigative Surgery - June 22, 2022 Category: Surgery Authors: Xinyu Liu Ping Zhang Xianqing Song Hengguan Cui Weixing Shen Source Type: research

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma
Conclusions: Taken together, our data for the first time demonstrate that S1P induced the macrophage-recruiting factor CCL2 expression in NB cells via S1P2, providing new insights into the complicated functions of S1P2 in cancer.
Source: Journal of Pediatric Surgery - May 19, 2014 Category: Surgery Authors: Mei-Hong Li, Miriam Harel, Timothy Hla, Fernando Ferrer Tags: Original Articles Source Type: research

Acellular dermal matrix-based gene therapy augments graft incorporation
Acellular dermal matrix (ADM) is widely used for structural or dermal replacement purposes. Given its innate biocompatibility and its potential to vascularize, we explored the possibility of ADM to function as a small interfering RNA (siRNA) delivery system. Specifically, we sought to improve ADM vascularization by siRNA-mediated inhibition of prolyl hydroxylase domain-2 (PHD2), a cytoplasmic protein that regulates hypoxia inducible factor-1α, and improve neovascularization.
Source: Journal of Surgical Research - January 30, 2015 Category: Surgery Authors: Meredith T. Vandegrift, Caroline Spzalski, Denis Knobel, Andrew Weinstein, Maria Ham, Obinna Ezeamuzie, Stephen M. Warren, Pierre B. Saadeh Source Type: research

Comparative analysis of polymers for short interfering RNA delivery in vascular smooth muscle cells
The use of short interfering RNA (siRNA) to degrade messenger RNA in the cell cytoplasm and transiently attenuate intracellular proteins shows promise in the inhibition of vascular pathogenesis. However, a critical obstacle for therapeutic application is a safe and effective delivery system. Biodegradable polymers are promising alternative molecular carriers for genetic material. Here, we aim to perform a comparative analysis of poly(B-amino ester) (PBAE) and polyethylenimine (PEI) polymers in their efficacy for vascular smooth muscle cell transfection using siRNA against the glyceraldehyde 3-phosphate dehydrogenase (GAPDH...
Source: Journal of Surgical Research - July 17, 2015 Category: Surgery Authors: Lindsay M. Bools, Richard K. Fisher, Oscar H. Grandas, Stacy S. Kirkpatrick, Joshua D. Arnold, Mitchell H. Goldman, Michael B. Freeman, Deidra J.H. Mountain Source Type: research

Significance of SYT8 For the Detection, Prediction, and Treatment of Peritoneal Metastasis From Gastric Cancer
Conclusions: SYT8 represents a promising target for the detection, prediction, and treatment of peritoneal metastasis of GC.
Source: Annals of Surgery - February 6, 2018 Category: Surgery Tags: Original Articles Source Type: research

The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF- κB/TLR4/NLRP3 Signals.
The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals. J Invest Surg. 2019 Jul 05;:1-13 Authors: Wang B, Wang J, Lu D, Qi N, Liu Q Abstract The aim of the current investigation was to study the role of 3-amino-2-hydroxy-4-phenyl-valyl-isoleucine (LYRM03) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its potential pathogenesis. An LPS-induced ALI model was produced with LPS (5 mg/kg) followed by 24 h of injury. Rats were randomly assigned to 6 groups for in vivo experiments: (1) Sham, (2) LYRM03 (20 mg/kg), (3) LPS, (4) LPS plus ...
Source: Journal of Investigative Surgery - July 7, 2019 Category: Surgery Tags: J Invest Surg Source Type: research

MANF Protects Pancreatic Acinar Cells Against Alcohol ‐induced Endoplasmic Reticulum Stress and Cellular injury
ConclusionsMANF was protective against alcohol ‐induced ER stress and cellular injury in pancreatic acinar cells. The findings suggest a potential therapeutic value of MANF for alcoholic pancreatitis.
Source: Journal of Hepato-Biliary-Pancreatic Surgery - March 1, 2021 Category: Surgery Authors: Huaxun Wu, Hui Li, Wen Wen, Yongchao Wang, Hong Xu, Mei Xu, Jacqueline A. Frank, Wei Wei, Jia Luo Tags: ORIGINAL ARTICLE Source Type: research

Roles of VE-Cadherin in Hypoxia Induced Injury of Pulmonary Microvascular Endothelial Barrier
CONCLUSIONS: These data verify that VE-cadherin expression played an important role in hypoxia induced PMVECs apoptosis and cellular skeletal recombination.PMID:34473045 | DOI:10.1532/hsf.3405
Source: Hand Surgery - September 2, 2021 Category: Surgery Authors: Lizhe Zhong Xiurong Gao Yongli Chen Zhaoxiang Yu Shuo Jin Chunlei Zhu Source Type: research

Effective Intraluminal Delivery of TSP-2 SiRNA to Reduce Intimal Hyperplasia in a Rat Model
Intimal hyperplasia represents a complex pathologic vascular response to injury. Our group previously identified several candidate genes associated with this response. Following implantation of interpositional prosthetic grafts in canine carotid arteries, thrombospondin-2 (TSP-2) was consistently found to be upregulated in the intimal hyperplastic lesion occurring at the anastomosis at 7-, 14-, and 30-day periods. Thus, we sought to determine whether silencing of this gene could attenuate the response to injury and reduce neointima formation in an in vivo model.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: W.B. Pratt, J.D. Glaser, M.A. Contreras, L. Pradhan-Nabzdyk, F.W. LoGerfo Tags: Oral Session: Thursday 2/7 7:30 AM to 9:30 AM Source Type: research

Therapeutic Implications of MSC-mediated Delivery of SiRNA Via Gap Junctions in the Treatment of Colon Cancer
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K. Chang, S. Kosari, J. Karas, T. Gregg, P. Brink, R. Bergamaschi Tags: Quickshot Session: Thursday 2/7 3:30 PM to 5:30 PM Source Type: research

Gαq G proteins modulate MMP-9 gelatinase during remodeling of the murine femoral artery
Conclusions: These data demonstrate that femoral wire injury in the mouse is associated with a time-dependent increase in Gαq expression. Inhibition of Gαq alters cell proliferation and is associated with decreased MMP-9 expression and activity.
Source: Journal of Surgical Research - May 9, 2012 Category: Surgery Authors: Yiping Zou, Yuyang Fu, Mark G. Davies Tags: Association for Academic Surgery Source Type: research

Involvement of down-regulated E2F3 in Hirschsprung's disease
Conclusions: This is the first study showing the down-regulation of E2F3 in HSCR, bringing new insight to the mechanism of the impaired migration of neural crest cells.
Source: Journal of Pediatric Surgery - April 1, 2013 Category: Surgery Authors: Weibing Tang, Junwei Tang, Jingjing Qin, Qiming Geng, Zhigang Zhou, Bo Li, Jie Zhang, Huan Chen, Yankai Xia, Xinru Wang Tags: Original Articles Source Type: research

Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
Conclusion: These data might be used along with other markers to predict response to radiation in patients with rectal cancer.
Source: Surgery - August 1, 2013 Category: Surgery Authors: Sergio Huerta, Xiaohuan Gao, Sean Dineen, Payal Kapur, Debrabata Saha, Jeffrey Meyer Tags: Society of University Surgeons Source Type: research

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