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Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer
ConclusionTMPRSS4 can be considered as a potential prognostic biomarker, especially for stage III, and a promising therapeutic target for GC.
Source: Journal of Gastrointestinal Surgery - August 11, 2021 Category: Surgery Source Type: research

COL11A1 Was Involved in Cell Proliferation, Apoptosis and Migration in Non-Small Cell Lung Cancer Cells.
CONCLUSION: The present study revealed that COL11A1 may contribute to the malignancy and involve in the pathogenesis of lung cancer. PMID: 33148075 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - November 7, 2020 Category: Surgery Tags: J Invest Surg Source Type: research

Significance of SYT8 For the Detection, Prediction, and Treatment of Peritoneal Metastasis From Gastric Cancer
Conclusions: SYT8 represents a promising target for the detection, prediction, and treatment of peritoneal metastasis of GC.
Source: Annals of Surgery - February 6, 2018 Category: Surgery Tags: Original Articles Source Type: research

Pre-Clinical Evaluation of Combined Proteasome and Spliceosome Inhibition in Triple Negative Breast Cancer (TNBC)
TNBC is an aggressive subtype that comprises 15% of breast cancer diagnoses. Non-targeted cytotoxic therapies are prone to resistance, metastasis, and recurrence. siRNA screening has revealed the selective necessity of proteasome and spliceosome function for the survival of TNBC cells arrested in a progenitor-like state. We explore inhibiting these pathways simultaneously, with the proteasome inhibitor Bortezomib and the splicing inhibitor E7107.
Source: Journal of the American College of Surgeons - October 1, 2017 Category: Surgery Authors: Praveen Sridhar, Stefanie Chan, Fabio Petrocca, Ying-Jie Lock Tags: Scientific poster presentation Source Type: research

Silencing the livin gene enhances the cytotoxic effects of anticancer drugs on colon cancer cells.
CONCLUSION: siRNA-mediated down-regulation of livin gene expression could significantly suppress colon cancer growth and enhance the cytotoxic effects of anticancer drugs such as 5-FU and L-OHP. The results of this study suggest that silencing livin gene expression in combination with treatment with anticancer drugs might be a novel cancer therapy for colorectal cancer. PMID: 27904848 [PubMed - in process]
Source: Annals of Surgical Treatment and Research - December 3, 2016 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma
Conclusions: Taken together, our data for the first time demonstrate that S1P induced the macrophage-recruiting factor CCL2 expression in NB cells via S1P2, providing new insights into the complicated functions of S1P2 in cancer.
Source: Journal of Pediatric Surgery - May 19, 2014 Category: Surgery Authors: Mei-Hong Li, Miriam Harel, Timothy Hla, Fernando Ferrer Tags: Original Articles Source Type: research

Blockage of CXCR2 suppresses tumor growth of intrahepatic cholangiocellular carcinoma
Conclusion: Our results demonstrated that blocking CXCR2 clearly suppressed the development of ICC. Blocking CXCR2 may be a promising therapeutic approach for ICC.
Source: Surgery - January 6, 2014 Category: Surgery Authors: Hideaki Sueoka, Tadamichi Hirano, Yugo Uda, Yuji Iimuro, Junichi Yamanaka, Jiro Fujimoto Tags: Original Communications Source Type: research

Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts
Conclusion: These data might be used along with other markers to predict response to radiation in patients with rectal cancer.
Source: Surgery - August 1, 2013 Category: Surgery Authors: Sergio Huerta, Xiaohuan Gao, Sean Dineen, Payal Kapur, Debrabata Saha, Jeffrey Meyer Tags: Society of University Surgeons Source Type: research

Murine portal vein catheterization to analyze liver-directed therapies
Conclusions: Liver-directed therapy can provide the selective delivery of siRNA to CRC metastases. EpCAM expression in CRC, but not normal liver, could further selectively target hepatic metastases of epithelial origin.
Source: Journal of Surgical Research - July 18, 2013 Category: Surgery Authors: Joseph D. Valentino, Piotr G. Rychahou, W. Conan Mustain, Victoria A. Elliott, B. Mark Evers Tags: Oncology/Endocrine Source Type: research

Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth
Conclusions: Silencing GRP78 not only inhibits tumor, but also decreases the expression of VEGF and VEGFR2. Collectively, therapy targeting for GRP78 may inhibit the formation of colon cancer tumors via the HIF-1α/VEGF/VEGFR2 pathway.
Source: Journal of Surgical Research - May 30, 2013 Category: Surgery Authors: Li-Jen Kuo, Chin-Sheng Hung, Wei-Yu Chen, Yu-Jia Chang, Po-Li Wei Tags: Oncology/Endocrine Source Type: research

Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells
Conclusions: MiR-21 is induced by hypoxia in pancreatic cancer cells via HIF-1α upregulation. MiR-21 overexpression allows cells to avoid apoptosis in a hypoxic microenvironment. Inhibition of miR-21 expression may increase cellular susceptibility to hypoxia in pancreatic cancer.
Source: Journal of Surgical Research - May 20, 2013 Category: Surgery Authors: Thomas A. Mace, Amy L. Collins, Sylwia E. Wojcik, Carlo M. Croce, Gregory B. Lesinski, Mark Bloomston Tags: Gastrointestinal Source Type: research

Therapeutic Implications of MSC-mediated Delivery of SiRNA Via Gap Junctions in the Treatment of Colon Cancer
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K. Chang, S. Kosari, J. Karas, T. Gregg, P. Brink, R. Bergamaschi Tags: Quickshot Session: Thursday 2/7 3:30 PM to 5:30 PM Source Type: research