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Specialty: Respiratory Medicine
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Total 598 results found since Jan 2013.
Lipopolysaccharide and lipoteichoic acid regulate the PI3K/AKT pathway through osteopontin/integrin β3 to promote malignant progression of non-small cell lung cancer
CONCLUSIONS: This study provides a theoretical basis for further exploration of the influence of lung microbiota on NSCLC and the optimization of LC treatment in the future.PMID:36794132 | PMC:PMC9922606 | DOI:10.21037/jtd-22-1825
Source: Journal of Thoracic Disease - February 16, 2023 Category: Respiratory Medicine Authors: Miao Zhang Yi Sun Yan Zhang Zhen Wang Zhao-Yi Wang Xi-Yue Ming Zhen-Dong Guo Source Type: research
Sesamin Induces the Transdifferentiation of Type II Alveolar Epithelial Cells via AnnexinA1 and TRPV1
ConclusionSesamin may promote transdifferentiation of ATII to ATI to ultimately rescue ALI, with TRPV1/AKT pathway involved in this transdifferentiation. This study revealed a novel role of sesamin in promoting the transdifferentiation of ATIIs to ATIs, providing experimental supports for the potential targets of ALI therapy.Graphical abstract
Source: Lung - February 3, 2023 Category: Respiratory Medicine Source Type: research
Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:36730646 | DOI:10.1165/rcmb.2022-0331OC
Source: Am J Respir Cell Mol... - February 2, 2023 Category: Respiratory Medicine Authors: Joseph S Bednash Finny Johns Daniela Farkas Ajit Elhance Jessica Adair Kirstin Cress Jacob S Yount Adam D Kenney James D Londino Rama K Mallampalli Source Type: research
RAGE inhibition alleviates lipopolysaccharides-induced lung injury via directly suppressing autophagic apoptosis of type II alveolar epithelial cells
CONCLUSION: RAGE plays an essential role in the pathogenesis of ATII cells injury. Our results suggested that RAGE inhibition alleviated LPS-induced lung injury by directly suppressing autophagic apoptosis of alveolar epithelial cells.PMID:36691012 | DOI:10.1186/s12931-023-02332-6
Source: Respiratory Care - January 23, 2023 Category: Respiratory Medicine Authors: Xi Xiong Jiaying Dou Jingyi Shi Yuqian Ren Chunxia Wang Yucai Zhang Yun Cui Source Type: research
Prenatal LPS Exposure Promotes Allergic Airway Inflammation via Long Coding RNA NONMMUT033452.2, and Protein Binding Partner, Eef1D
In this study, we found that prenatal lipopolysaccharide (LPS) exposure increased the airway resistance and total exfoliated cell counts, eosinophils, and interleukin (IL)-4 levels in the bronchoalveolar lavage fluid of ovalbumin-sensitized ICR mice. Importantly, lncRNA NONMMUT033452.2 was upregulated in the lungs of LPS-exposed ICR offspring. Fluorescence in situ hybridization and cytoplasmic-nuclear fraction analyses revealed that this lncRNA was distributed in both the nuclei and cytoplasm of lung and airway epithelial cells, smooth muscle cells, and fibroblasts. Intranasal administration of NONMMUT033452.2 siRNA marked...
Source: Am J Respir Cell Mol... - January 5, 2023 Category: Respiratory Medicine Authors: Jiuru Zhao Qianqian Zhang Dongting Yao Tao Wang Meng Ni Yin Xu Zheng Tang Zhiwei Liu Source Type: research
