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Total 598 results found since Jan 2013.
The mTORC2/SGK1/NDRG1 Signaling Axis Is Critical for Mesomesenchymal Transition of Pleural Mesothelial Cells and the Progression of Pleural Fibrosis
In conclusion, our studies demonstrate that mTORC2/Rictor-mediated activation of SGK1/NDRG1 are critical for MesoMT induction, and targeting this pathway could inhibit or even reverse the progression of MesoMT and PF.PMID:37607215 | DOI:10.1165/rcmb.2023-0131OC
Source: Am J Respir Cell Mol... - August 22, 2023 Category: Respiratory Medicine Authors: Shiva Keshava Shuzi Owens Wenyi Qin Ann Jeffers Perpetual Kyei Satoshi Komatsu Joshua Kleam Mitsuo Ikebe Steven Idell Torry A Tucker Source Type: research
Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Jul 24. doi: 10.1165/rcmb.2022-0315OC. Online ahead of print.ABSTRACTIdiopathic Pulmonary Fibrosis (IPF) is an interstitial lung disease characterized by progressive lung scarring and remodeling. Although treatments exist that slow disease progression, IPF is irreversible and there is no cure. Cellular senescence, a major hallmark of aging, has been implicated in IPF pathogenesis, and mitochondrial dysfunction is increasingly recognized as a driver of senescence. Adenine nucleotide translocases (ANTs) are abundant mitochondrial ATP-ADP transporters critical for regulating cell fate and maint...
Source: Am J Respir Cell Mol... - July 24, 2023 Category: Respiratory Medicine Authors: Justin Sui Jennifer C Boatz Jian Shi Qianjiang Hu Xiaoyun Li Yingze Zhang Melanie K önigshoff Corrine R Kliment Source Type: research
Contribution of TRPC channels in human and experimental pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00011.2023. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+-permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution t...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Bastien Masson Ana ïs Saint-Martin Willer Mary Dutheil Lucille Penalva H élène Le Ribeuz Kristelle El Jekmek Yann Ruchon Sylvia Cohen-Kaminsky Jessica Sabourin Marc Humbert Olaf Mercier David Montani V éronique Capuano Fabrice Antigny Source Type: research
Cyclophilin D Contributes to Airway Epithelial Mitochondrial Damage in Chronic Obstructive Pulmonary Disease
ConclusionThese data suggest that CypD signaling pathway is involved in the pathogenesis of COPD and provide a potential therapeutic target for COPD.
Source: Lung - June 1, 2023 Category: Respiratory Medicine Source Type: research
