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Specialty: Respiratory Medicine
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Total 598 results found since Jan 2013.
DNA-PKcs participated in hypoxic pulmonary hypertension
CONCLUSIONS: Our study indicated the potential mechanism of DNA-PKcs in the development of HPH. It might provide insights into new therapeutic targets for pulmonary vascular remodeling and pulmonary hypertension.PMID:36114572 | DOI:10.1186/s12931-022-02171-x
Source: Respiratory Care - September 16, 2022 Category: Respiratory Medicine Authors: Ying-Ying Liu Wei-Yun Zhang Meng-Lan Zhang Yu-Ji Wang Xi-Yan Ma Jung-Hong Jiang Ran Wang Da-Xiong Zeng Source Type: research
Endothelin-1 Depletion of Cartilage Oligomeric Matrix Protein Modulates Pulmonary Artery Superoxide and Iron Metabolism-associated Mitochondrial Heme Biosynthesis
This study examines if heme biosynthesis associated iron metabolism is regulated in pulmonary arteries by endothelin-1 (ET1) potentially through modulating Cartilage Oligomeric Matrix Protein (COMP) availability. Our studies in organoid cultured endothelium-rubbed bovine pulmonary arteries (BPA) observed COMP depletion by siRNA or hypoxia increases NOX2 and superoxide, and depletes mitochondrial SOD2. ET1 also increases superoxide in a manner that potentially impairs mitochondrial heme biosynthesis. In this study, organoid culture of BPA with ET1 (10nM) increases superoxide in the mitochondrial matrix and extra mitochondri...
Source: Am J Physiol Lung Ce... - August 9, 2022 Category: Respiratory Medicine Authors: Hang Yu Norah Alruwaili Melissa R Kelly Bin Zhang Aijing Liu Yingqi Wang Dong Sun Michael S Wolin Source Type: research
Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury
Am J Respir Cell Mol Biol. 2022 Jul 27. doi: 10.1165/rcmb.2021-0463OC. Online ahead of print.ABSTRACTCD55 or decay accelerating factor (DAF), a ubiquitously expressed glycosylphosphatidylinositol (GPI)-anchored protein, confers a protective threshold against complement dysregulation which is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Since lung fibrosis is associated with downregulation of DAF, we hypothesize that overexpression of DAF in fibrosed lungs will limit fibrotic injury by restraining complement dysregulation. Normal primary human alveolar type II epithelial cells (AECs) exposed to exogeno...
Source: Am J Respir Cell Mol... - July 27, 2022 Category: Respiratory Medicine Authors: Ragini Vittal Amanda J Fisher Eric L Thompson Ellyse M Cipolla Hongmei Gu Elizabeth A Mickler Ananya Varre Manisha Agarwal Kevin K Kim Michael R Vasko Bethany B Moore Vibha N Lama Source Type: research
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment
Am J Respir Cell Mol Biol. 2022 May 12. doi: 10.1165/rcmb.2021-0362OC. Online ahead of print.ABSTRACTRespiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants and young children. Axl, a TAM family receptor tyrosine kinase (RTK), has been demonstrated as a receptor mediating enveloped virus infection. Here we show that Axl functions as a suppressor of antiviral response during RSV infection. Knockdown of Axl expression in human cells resulted in cell resistance to RSV infection although the treatment did not significantly affect RSV binding or cell entry. Mice deficiency of...
Source: Am J Respir Cell Mol... - May 13, 2022 Category: Respiratory Medicine Authors: Dan Zhang Yuanhui Zhao Lingling Wang Xiaoxin You Jingjing Li Guohai Zhang Yayi Hou Hongwei Wang Susu He Erguang Li Source Type: research
The role of retinoid-related orphan receptor- α in cigarette smoke-induced autophagic response
CONCLUSIONS: Our findings suggest that RORα promotes autophagy and contributes to COPD pathogenesis via regulation of the RORα-p53-DRAM pathway.PMID:35509068 | DOI:10.1186/s12931-022-02034-5
Source: Respiratory Care - May 5, 2022 Category: Respiratory Medicine Authors: Hak-Su Kim Chang Hyeok An Danielle Teller Su-Jin Moon Gi Won Hwang Jin Woo Song Source Type: research
