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Upregulation of A20 and TAX1BP1 contributes to the anti-neuroinflammatory and antidepressant effects of bavachalcone
In conclusion, these results are the first to demonstrate that bavachalcone exerts anti-neuroinflammatory and antidepressant effects via inhibition of the NF-κB pathway mediated by upregulating A20 and TAX1BP1, and may be a potential candidate for the treatment of neuroinflammation-related diseases, including depression.PMID:37393841 | DOI:10.1016/j.intimp.2023.110552
Source: International Immunopharmacology - July 2, 2023 Category: Allergy & Immunology Authors: Xintong Wu Zhonghong Zhang Xiao Zhang Yaping Guo Feng Liu Jianwei Gong Li Li Xinyu Chen Zhipeng Li Source Type: research

Chrysin alleviates lipopolysaccharide-induced neuron damage and behavioral deficits in mice through inhibition of Fyn
In this study, we discovered that chrysin, a natural flavonoid compound, suppressed the activation of Fyn kinase and further alleviated neuroinflammation-induced neuron damage and behavior deficits. Functionally, chrysin improved lipopolysaccharide (LPS)-induced memory impairment and depressive behaviors in mice, it also protected against LPS-induced neuronal degeneration and loss and synaptic defects in mice. Our study demonstrated that chrysin inhibited the activation of microglia and reduced the expression of NLRP3 and IL-1β. Furthermore, our data indicated that chrysin blocked phosphorylation of Fyn and activation of ...
Source: International Immunopharmacology - August 13, 2022 Category: Allergy & Immunology Authors: Qingchen Wang Zhiping Yang Xintong Wu Xiao Zhang Feng Geng Qiaoyun Wang Zikai Geng Chen Yu Zhipeng Li Source Type: research

LINC00488 Induces Tumorigenicity in Retinoblastoma by Regulating microRNA-30a-5p/EPHB2 Axis
CONCLUSION: LINC00488 induces tumorigenicity in RB by binding to miR-30a-5p to target EPHB2, which may offer a new clue of RB treatment from an lncRNA-miRNA-mRNA network.PMID:35404750 | DOI:10.1080/09273948.2022.2037659
Source: Ocular Immunology and Inflammation - April 11, 2022 Category: Allergy & Immunology Authors: Xuehao Cui Tingyi Liang Xunda Ji Yan Shao Peiquan Zhao Xiaorong Li Source Type: research

Up-regulation of miR-365 promotes the apoptosis and restrains proliferation of synoviocytes through downregulation of IGF1 and the inactivation of the PI3K/AKT/mTOR pathway in mice with rheumatoid arthritis.
CONCLUSION: Our study presents that up-regulation of miR-365 drives on apoptosis and restrains proliferation of synoviocytes in RA through downregulation of IGF1 and the inhibition of the PI3K/AKT/mTOR pathway. Thus, miR-365 may be a potential candidate for treatment of RA. PMID: 31881377 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - December 23, 2019 Category: Allergy & Immunology Authors: Wang X, Gong S, Pu D, Hu N, Wang Y, Fan P, Zhang J, Lu X Tags: Int Immunopharmacol Source Type: research

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Inflammation is a crucial component of various stress-induced responses that contributes to the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is characterized by decreased mobility and depressive behavior that occurs in systemic infection induced by Lipopolysaccharide (LPS) in experimental animals and is considered as a model of exacerbation of MDD. We assessed the effects of melatonin on behavioral changes and inflammatory cytokine expression in hippocampus of mice in LPS-induced DLB, as well as its effects on NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation, oxidative...
Source: Frontiers in Immunology - July 1, 2019 Category: Allergy & Immunology Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus
Publication date: November 2017 Source:Molecular Immunology, Volume 91 Author(s): Zhen Zhang, Zhimeng Lv, Zhixin Wei, Chenghua Li, Yina Shao, Weiwei Zhang, Xuelin Zhao, Jinbo Xiong Microsomal glutathione transferase 2 (mGST2) is an integral membrane protein involved in detoxication of xenobiotics, and has also been suggested to catalyze the biosynthesis of pro-inflammatory mediator leukotriene C4 (LTC4) as homologous to LTC4 synthase (LTC4S) in mammals. In the present study, a novel mGST2 homology was identified from Apostichopus japonicus (designated as AjmGST2) by RACE approaches. The full-length cDNA of AjmGST2 was of ...
Source: Molecular Immunology - September 9, 2017 Category: Allergy & Immunology Source Type: research

miR210 modulates respiratory burst in Apostichopus japonicus coelomocytes via targeting Toll-like receptor.
Abstract Immune responses of species in Echinodermata remains mysterious due to the lack of efforts made in the study of host defense mechanism in these species. More researches start focusing on this ancient immune system with the recognition the economic values of several species in this phylum, especially sea cucumbers. Here, we reported a study in the innate immunity of a sea cucumber species (Apostichopus japonicus) in response to infection of Vibrio splendidus. A novel differential expressed miRNA (miR-210) from the diseased sea cucumber coelomocytes was identified in our study. This miRNA molecule modulates...
Source: Developmental and Comparative Immunology - August 17, 2016 Category: Allergy & Immunology Authors: Li C, Zhao M, Zhang C, Zhang W, Zhao X, Duan X, Xu W Tags: Dev Comp Immunol Source Type: research