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Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. J Clin Biochem Nutr. 2020 Nov;67(3):248-256 Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB Abstract The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Chrysanthemum extract attenuates hepatotoxicity via inhibiting oxidative stress in vivo and in vitro.
Conclusions: BZE plays an important role in preventing hepatotoxicity by inhibiting oxidative stress and apoptosis through activation of Nrf2 signaling. BZE could be developed as an effective functional food for protecting the liver. PMID: 31024225 [PubMed]
Source: Food and Nutrition Research - April 27, 2019 Category: Nutrition Authors: Tian Z, Jia H, Jin Y, Wang M, Kou J, Wang C, Rong X, Xie X, Han G, Pang X Tags: Food Nutr Res Source Type: research

Commensal lactic acid-producing bacteria affect host cellular lipid metabolism through various cellular metabolic pathways: Role of mTOR, FOXO1, and autophagy machinery system
ConclusionLAPB prevent high- fat diet/endotoxin/inflammation-mediated disruption of normal cellular lipid metabolism by inhibiting mTOR/FOXO1/NF-kB activity and enhancing the occurrence of autophagy. This may be a molecular basis by which LAPB enhance intrinsic cellular tolerance against excess calorie consumption and participate in homeostatic regulation of metabolic processes in vivo.Graphical abstract
Source: PharmaNutrition - October 25, 2018 Category: Nutrition Source Type: research

Activation of Nrf2-Antioxidant Signaling by 1,25-Dihydroxycholecalciferol Prevents Leptin-Induced Oxidative Stress and Inflammation in Human Endothelial Cells Biochemical, Molecular, and Genetic Mechanisms
Conclusion: Pretreatment with 1,25(OH)2D3 in the presence of a high concentration of leptin has a beneficial effect on HUVECs through the regulation of mediators of antioxidant activity and inflammation.
Source: Journal of Nutrition - April 3, 2017 Category: Nutrition Authors: Teixeira, T. M., da Costa, D. C., Resende, A. C., Soulage, C. O., Bezerra, F. F., Daleprane, J. B. Tags: Obesity and Metabolism Research Articles Biochemical, Molecular, and Genetic Mechanisms Source Type: research

Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
In conclusion, DHA inhibits H. pylori‐induced STAT3 phosphorylation in a PPARγ/SOCS3‐dependent manner. This article is protected by copyright. All rights reserved
Source: Nahrung / Food - March 31, 2016 Category: Nutrition Authors: Hyeon‐Geun Ji, Juan‐Yu Piao, Su‐Jung Kim, Do‐Hee Kim, Ha‐Na Lee, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Punicalagin attenuates palmitate‐induced lipotoxicity in HepG2 cells by activating the Keap1‐Nrf2 antioxidant defense system
Conclusions: These findings suggest that punicalagin could effectively attenuate FFA‐induced lipotoxicity by activating Keap1‐Nrf2 cytoprotective signaling pathway.This article is protected by copyright. All rights reserved
Source: Nahrung / Food - March 15, 2016 Category: Nutrition Authors: Chunhong Yan, Wenyan Sun, Xun Wang, Jiangang Long, Xuebo Liu, Zhihui Feng, Jiankang Liu Tags: Research Article Source Type: research

Quercetin differently regulates insulin‐mediated glucose transporter 4 translocation under basal and inflammatory conditions in adipocytes
ConclusionQuercetin demonstrated divergent effects on insulin‐mediated GLUT4 translocation in adipocytes under basal and insulin resistant conditions, which were related to its regulation of AMPK activity.
Source: Nahrung / Food - December 1, 2013 Category: Nutrition Authors: Manli Xu, Juanjuan Hu, Wenwen Zhao, Xuejiao Gao, Cuihua Jiang, Kang Liu, Baolin Liu, Fang Huang Tags: Research Article Source Type: research

In vitro mechanism for downregulation of ER‐α expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells
ConclusionOur data provide evidence for a mechanism by which EGCG downregulates ER‐α and explains the inhibitory action of EGCG on the proliferation of ER+ PR+ cancer cells tested. We suggest that the EGCG/PR‐B signaling should be further exploited for clinical approach.
Source: Molecular Nutrition - January 1, 2013 Category: Nutrition Authors: Francesca De Amicis, Alessandra Russo, Paola Avena, Marta Santoro, Adele Vivacqua, Daniela Bonofiglio, Loredana Mauro, Saveria Aquila, Donatella Tramontano, Suzanne AW Fuqua, Sebastiano Andò Tags: Research Article Source Type: research