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Specialty: Hematology
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Total 236 results found since Jan 2013.
Thrombin receptor PAR1 silencing in endothelial colony forming cells modifies stemness and vasculogenic properties
CONCLUSIONS: In conclusion, our work describes for the first time a link between PAR1, stemness and vasculogenesis in human ECFCs.PMID:37678550 | DOI:10.1016/j.jtha.2023.08.029
Source: Thrombosis and Haemostasis - September 7, 2023 Category: Hematology Authors: David M Smadja Elisa Rossi Skerdi Haviari Ivan Bieche Audrey Cras Pascale Gaussem Source Type: research
Bioinformatic identification and experiment validation revealed ACTG1 is a promising prognostic signature and therapeutic target for sepsis
J Leukoc Biol. 2023 Jun 27:qiad072. doi: 10.1093/jleuko/qiad072. Online ahead of print.ABSTRACTIn the Intensive Care Unit (ICU), sepsis is a prevalent clinical syndrome that is the final pathway to death from most infections. Peripheral blood gene expression profiling is becoming more and more accepted as a potential diagnostic or prognostic tool. This work aimed to recognize genes related to sepsis, providing potential translational therapeutic targets. RNA sequencing was performed on peripheral blood mononuclear cells (PBMCs) from 20 healthy controls and 51 sepsis patients. Weighted gene co-expression network analysis (W...
Source: Journal of Leukocyte Biology - June 27, 2023 Category: Hematology Authors: Hua Yao Yue Zhou Tingting Li Yao Li Fan Li Geng Zhang Xin Fu Yan Kang Qin Wu Source Type: research
Assessment of breast cancer progression and metastasis during a hypercoagulable state induced by silencing of antithrombin in a xenograft mouse model
Local coagulation activation has been shown to impact both primary tumor growth and metastasis in mice. It is well known that components of the blood clotting cascade such as tissue factor and thrombin play a role in tumor progression by activating cellular receptors and local formation of fibrin. However, whether venous thromboembolism (VTE) or a hypercoagulable state has a direct impact on cancer progression is unknown. Here we have combined an orthotopic murine breast cancer model, using female Nod-SCID mice, with siRNA-mediated silencing of antithrombin (siAT) leading to the induction of a systemic hypercoagulable state.
Source: Thrombosis Research - November 24, 2022 Category: Hematology Authors: J.T. Buijs, B. Ünlü, E.H. Laghmani, M. Heestermans, B.J.M. van Vlijmen, H.H. Versteeg Tags: Full Length Article Source Type: research
Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies
CONCLUSIONS: Consistent with prior studies, Fib𝛾390-396A mice were significantly protected from increased adiposity, NAFLD, hypercholesterolemia and diabetes while Fib- and siFga-treated mice gained as much weight and developed obesity-associated pathologies identical to wildtype mice. FibAEK and FXIII- mice displayed an intermediate phenotype with partial protection from some obesity-associated pathologies. Results here indicate that fibrin(ogen) lacking αM β2 binding function offers substantial protection from obesity and associated disease that is partially recapitulated by preventing fibrin polymer formation or cr...
Source: Thrombosis and Haemostasis - September 16, 2022 Category: Hematology Authors: Woosuk S Hur Katharine C King Yesha N Patel Y-Van Nguyen Zimu Wei Yi Yang Lih Jiin Juang Jerry Leung Christian J Kastrup Alisa S Wolberg James P Luyendyk Matthew J Flick Source Type: research
Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury
CONCLUSION: Chronic reduction of PTP1B in SMCs promotes dedifferentiation, perivascular fibrosis, and adverse remodeling following vascular injury by mechanisms involving an ERK1/2 phosphorylation-driven shift from SMAD2 to KLF4-regulated gene transcription.PMID:36075234 | DOI:10.1055/s-0042-1755329
Source: Thrombosis and Haemostasis - September 8, 2022 Category: Hematology Authors: Rajinikanth Gogiraju Sogol Gachkar David Velmeden Magdalena L Bochenek Konstantinos Zifkos Astrid Hubert Thomas M ünzel Stefan Offermanns Katrin Sch äfer Source Type: research
RUNX1 inhibition using lipid nanoparticle-mediated siRNA delivery as an effective treatment for acute leukemias
RUNX1 is one of three mammalian RUNX members, along with RUNX2 and RUNX3. RUNX1 contains a conserved Runt domain that mediates DNA binding and heterodimerization to their partner protein CBFB. RUNX1 and CBFB form a complex that regulates hematopoietic gene expression1-3. Disruption of RUNX1 has been implicated in the development of hematopoietic neoplasms. Chromosomal abnormalities involving the RUNX1 gene are associated with several types of leukemia, including acute myeloid leukemia (AML) driven by RUNX1-RUNX1T14,5.
Source: Experimental Hematology - May 25, 2022 Category: Hematology Authors: Kohei Iida, Akiho Tsuchiya, Moe Tamura, Keita Yamamoto, Shigehisa Kawata, Mitsuko Ishihara-Sugano, Motohiro Kato, Toshio Kitamura, Susumu Goyama Tags: Category: Malignant Hematopoiesis Source Type: research
Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells
CONCLUSIONS: Release of VWF from endothelial cells opens the platelet-binding site, irrespective of the presence of flow. However, not all available platelet-binding sites are being occupied, suggesting some extent of regulation. Part of this regulation involves endothelial proteins that are co-secreted with VWF, like osteoprotegerin. This regulatory mechanism may be of more relevance under inflammatory conditions.PMID:34816579 | DOI:10.1111/jth.15598
Source: Thrombosis and Haemostasis - November 24, 2021 Category: Hematology Authors: Nikolett Wohner Silvie Sebastian Vincent Muczynski Dana Huskens Bas de Laat Philip G de Groot Peter J Lenting Source Type: research
Sinomenine increases adenosine A < sub > 2A < /sub > receptor and inhibits NF- κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR
J Leukoc Biol. 2021 Aug 23. doi: 10.1002/JLB.3MA0121-024RRRR. Online ahead of print.ABSTRACTSinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti-inflammatory and immunosuppressive function. However, the mechanisms of SIN acting on α7nAChR and the effect on adenosine A2A receptor (A2A R) in RA are not clear. In the present study, the effects of SIN on adjuvant-induced-arthritis (AIA) rats in vivo and on fibroblast-like synoviocyte...
Source: Journal of Leukocyte Biology - August 23, 2021 Category: Hematology Authors: Lang Yi Junyu Ke Jiayan Liu Huili Lai Yanjun Lv Chong Peng Yingkun Zhi Qun Du Liang Liu Peixun Wang Hua Zhou Yan Dong Source Type: research
MicroRNA expression changes following BCL11A inhibition in CD34+-derived red blood cells
CONCLUSIONS: The expression levels of miR-15a, miR-16, miR-23a, miR-27a, and miR-486 changed before and after γ-to-β gene switching. Therefore, this may be an effective intervention for controlling the switching and synthesis of fetal hemoglobin.PMID:33707350 | DOI:10.5045/br.2021.2020087
Source: Blood Research - March 12, 2021 Category: Hematology Authors: Narges Obidi Fatemeh Saberi Asad Taghavi Reza Ranjbaran Gholamreza Khamisi Pour Gholamhossein Tamaddon Source Type: research
