Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells

CONCLUSIONS: Release of VWF from endothelial cells opens the platelet-binding site, irrespective of the presence of flow. However, not all available platelet-binding sites are being occupied, suggesting some extent of regulation. Part of this regulation involves endothelial proteins that are co-secreted with VWF, like osteoprotegerin. This regulatory mechanism may be of more relevance under inflammatory conditions.PMID:34816579 | DOI:10.1111/jth.15598
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Source Type: research

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Microvascular coronary collaterals invisible on angiography provided 60% of perfusion to jeopardized myocardium during balloon coronary occlusion in patients with coronary artery disease.First Look
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
Cureus. 2021 Dec 14;13(12):e20403. doi: 10.7759/cureus.20403. eCollection 2021 Dec.ABSTRACTThe authors present a case of a Baker's cyst in the right leg of an 86-year-old woman, whose presentation was more typical for a deep venous thrombosis. Both conditions have inflammation and acute calf pain. The clinical manifestations, imaging findings, and treatment of this common emergency department presentation are discussed.PMID:35036229 | PMC:PMC8754354 | DOI:10.7759/cureus.20403
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
Am J Transl Res. 2021 Dec 15;13(12):13516-13523. eCollection 2021.ABSTRACTOBJECTIVE: To determine the short-term prognostic value of Computed Tomography (CT) perfusion parameters in patients with advanced non-small cell lung cancer (NSCLC) after chemotherapy.METHODS: A total of 60 patients with NSCLC who received concurrent radiotherapy and chemotherapy were enrolled. Before therapy, CT perfusion imaging was conducted to scan their local lesions. Then, the CT perfusion-associated parameters were recorded, and evaluated. According to the Response Evaluation Criteria in Solid Tumors (RECIST), 42 out of 60 patients had remiss...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: The DMFBB shows a promising alternative bioreactor for use in bioartificial liver support systems for application of clinical practice.PMID:35034506 | DOI:10.1177/03913988211066502
Source: The International Journal of Artificial Organs - Category: Transplant Surgery Authors: Source Type: research
J Atheroscler Thromb. 2022 Jan 15. doi: 10.5551/jat.ED188. Online ahead of print.NO ABSTRACTPMID:35034921 | DOI:10.5551/jat.ED188
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
CONCLUSION: Mild hypertensive retinopathy was positively associated with CVD and stroke risk in the urban Japanese population. Especially, generalized arteriolar narrowing and enhanced arteriolar wall reflex were positively associated with CVD risk. These findings suggested that retinal photography could be helpful for cardiovascular risk stratification in the primary cardiovascular prevention.PMID:35034920 | DOI:10.5551/jat.63317
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
CONCLUSION: The use of ipsilateral transulnar access is a feasible and safe alternative in cases where radial access would be impossible. This access site is associated with a low incidence of complications, which, when present, are most commonly associated with the occurance of spasm after the attempted radial puncture.PMID:35037897
Source: The Journal of Invasive Cardiology - Category: Cardiology Authors: Source Type: research
Semin Thromb Hemost DOI: 10.1055/s-0037-1607440von Willebrand disease (VWD), the most commonly known inherited bleeding disorder, is caused by a partial (type 1) or total (type 3) deficiency or dysfunction (type 2) of von Willebrand factor (VWF). Its management encompasses the prevention or treatment of bleeding by raising endogenous VWF levels using a synthetic agent, such as desmopressin, or providing exogenous VWF concentrates. The development of inhibitory alloantibodies against VWF is a rare but often severe complication encountered during the treatment of type 3 VWD, which is associated with a lack of hemostatic resp...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
Semin Thromb HemostDOI: 10.1055/s-0036-1581106Although in most cases von Willebrand disease (VWD) is a mild disorder, a subgroup of patients experience frequent bleeding. In contrast to severe hemophilia in which prophylaxis is the accepted standard of care, this is less frequently used in VWD. Most type 1 VWD patients can be adequately managed with episodic desmopressin and tranexamic acid. In patients with more severe disease, especially those with type 3 VWD, joint bleeds, epistaxis, menorrhagia, and gastrointestinal bleeding are problematic and usually require treatment with von Willebrand factor/factor VIII (VWF/FVIII...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Source Type: research
Semin Thromb HemostDOI: 10.1055/s-0035-1564844Besides its essential role in hemostasis, there is growing evidence that von Willebrand factor (VWF) has an additional antitumor effect. To elucidate the clinical significance of this biological activity we conducted a retrospective study on cancers among Italian patients with von Willebrand disease (VWD) on behalf of the Italian Association of Haemophilia Centres (AICE). A questionnaire to collect demographic, clinical, and treatment data of VWD patients with cancer was sent to all the 54 Italian Haemophilia Treatment Centres (HTCs) members of AICE. Overall, 18 HTCs (33%) prov...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Source Type: research
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