• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Evaluation of an Integrin αvβ3 Radiotracer, 18FF-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver
ConclusionThis study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

Evaluation of 18 FF-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy
Conclusions[18F]F-DPA can detect changes in TSPO expression levels after RT in HNSCC, which does not seem to reflect inflammation. Further studies are however needed to clarify the physiological mechanisms regulated by TSPO after RT.
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 19, 2020 Category: Nuclear Medicine Source Type: research

Non-canonical TSHR signaling activation increases cell mobility and dedifferentiation of thyroid cancer
Conclusions: Our results elucidate non-canonical activation of TSH-TSHR signaling and its role in increasing cell mobility and dedifferentiation in thyroid cancer through crosstalk with PI3K/AKT/mTOR signaling.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Feng, F., WU, S., Wang, H. Tags: Oncology, Basic and Translational (Basic Science) II Source Type: research

The preclinical characterization of 18FhGTS13 for imaging of xC- transporter activity
Conclusion: [18F]hGTS13 is a novel radiotracer for measuring xC- transporter activity. It showed high and specific uptake in cell assays with A549 and H460 cells. [18F]hGTS13 showed significantly lower uptake in activated T cells compared to [18F]FSPG. PET/CT imaging of [18F]hGTS13 in H460 tumor bearing rats revealed significantly higher tumor uptake than [18F]FSPG.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Beinat, C., Gowrishanker, G., Shen, B., Alam, I., Robinson, E., Ilovich, O., Koglin, N., Schmitt-Willich, H., Berndt, M., Mueller, A., Zerna, M., Srinivasan, A., Gambhir, S. Tags: Preclinical Probes for Oncology III Source Type: research

Effect of IDH3{alpha} on glucose uptake in lung adenocarcinoma
Conclusion: High expression of IDH3α in lung adenocarcinoma patients showed higher glucose uptake than low expression ones. IDH3α affect glucose uptake of lung cancer through AKT-GLUT1 pathway, the down-regulation of IDH3α can reduce the generation of lactic acid in tumor cells.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Du, B., Li, X., Li, Y. Tags: Basic Science Posters (Oncology) Source Type: research

Construction and characterization of cRGD-modified 9-arginine peptide as a novel vector for targeted siRNA delivery
Conclusions The chimaeric peptide of c(RGD)2-9R is considered to be an effective siRNA delivery vector in vitro, and a hopeful application in vivo needs further examination.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Liu, M., Chen, X., Wang, R., Yan, P., Zhang, C. Tags: MTA I: Basic Science Posters Source Type: research

Synthesis of a stabilized 177Lu–siRNA complex and evaluation of its stability and RNAi activity
In this study, the effects of PS and 2′-O-Me modifications at the backbone of siRNA on serum stability and RNA interference activity were investigated. Materials and methods: Fully PS and 2′-O-Me-modified type 1 insulin-like growth factor receptor (IGF-1R) siRNA was radiolabeled with lutetium-177 (177Lu) through p-SCN-Bn-DTPA as a chelator. After purification with Vivaspin and PD-10 columns, the radiolabs were examined for stability in serum by instant thin-layer chromatography and polyacrylamide gel electrophoresis. The level of IGF-1R in response to the modified and labeled IGF-1R siRNA was examined using RT-PCR and ...
Source: Nuclear Medicine Communications - April 28, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research

siRNA distribution and pharmacokinetics assessed by nuclear imaging are modulated according to radiolabelling site
This study aimed at defining the biodistribution and pharmacokinetics properties of a siRNA directed to the Casein Kinase-2 beta (CK2β) subunit, a potential target in cancer therapy.
Source: Nuclear Medicine and Biology - April 24, 2015 Category: Nuclear Medicine Authors: Dominique Garin, Mitra Ahmadi, Anne-Sophie Gauchez, Sylvain Bohic, Sandra Boccard, Peter Cloetens, Daniel Fagret, François Berger, Arnaud Briat, Laurent Pelletier, Catherine Ghezzi Source Type: research