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Total 17 results found since Jan 2013.

Evaluation of an Integrin αvβ3 Radiotracer, 18FF-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver
ConclusionThis study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer
Conclusion The [99mTc]HYNIC-siRNA 1489 was taken up by the tumor, which had a high level of MDM2. The probe exhibited a sufficient retention time in the tumor. This probe may be an effective strategy for evaluating MDM2 expression and achieving early diagnosis in breast cancer.
Source: Nuclear Medicine Communications - July 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

P53 mediates the stimulation of mitochondrial reactive oxygen species and suppression of 18F-FDG uptake and glycolysis in isoprenaline-treated H9C2 cardiomyocytes
Conclusions: These findings demonstrate that ISO treatment decreases cardiomyocyte 18F-FDG uptake by downregulating glycolytic flux and further reveals that ROS-p53 signaling plays a critical role in this metabolic response.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Lee, J. H., Kim, D. H., Kim, M., Cho, Y. S., Jung, K.-H., LEE, K.-H. Tags: Cardiovascular Basic Science Source Type: research

Evaluation of 18 FF-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy
Conclusions[18F]F-DPA can detect changes in TSPO expression levels after RT in HNSCC, which does not seem to reflect inflammation. Further studies are however needed to clarify the physiological mechanisms regulated by TSPO after RT.
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 19, 2020 Category: Nuclear Medicine Source Type: research

Non-canonical TSHR signaling activation increases cell mobility and dedifferentiation of thyroid cancer
Conclusions: Our results elucidate non-canonical activation of TSH-TSHR signaling and its role in increasing cell mobility and dedifferentiation in thyroid cancer through crosstalk with PI3K/AKT/mTOR signaling.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Feng, F., WU, S., Wang, H. Tags: Oncology, Basic and Translational (Basic Science) II Source Type: research

The preclinical characterization of 18FhGTS13 for imaging of xC- transporter activity
Conclusion: [18F]hGTS13 is a novel radiotracer for measuring xC- transporter activity. It showed high and specific uptake in cell assays with A549 and H460 cells. [18F]hGTS13 showed significantly lower uptake in activated T cells compared to [18F]FSPG. PET/CT imaging of [18F]hGTS13 in H460 tumor bearing rats revealed significantly higher tumor uptake than [18F]FSPG.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Beinat, C., Gowrishanker, G., Shen, B., Alam, I., Robinson, E., Ilovich, O., Koglin, N., Schmitt-Willich, H., Berndt, M., Mueller, A., Zerna, M., Srinivasan, A., Gambhir, S. Tags: Preclinical Probes for Oncology III Source Type: research

Effects of RNAi Silencing CITED1 Gene on Biological Function of Thyroid Carcinoma Cell Line K1
Conclusions: CITED1 gene may affect the occurrence and development of thyroid papillary cancer by promoting tumor cell proliferation and migration,and inhibiting apoptosis. Key words: CITED1, K1, RNAi, apoptosis, proliferation
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Pang, H. Tags: Educational Exhibits Source Type: research

Effect of IDH3{alpha} on glucose uptake in lung adenocarcinoma
Conclusion: High expression of IDH3α in lung adenocarcinoma patients showed higher glucose uptake than low expression ones. IDH3α affect glucose uptake of lung cancer through AKT-GLUT1 pathway, the down-regulation of IDH3α can reduce the generation of lactic acid in tumor cells.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Du, B., Li, X., Li, Y. Tags: Basic Science Posters (Oncology) Source Type: research

The imaging research of chemokine receptor 4
Conclusions: With the bifunctional chelator HYNIC and SnCl2,the CXCR4 siRNA molecules probe that labeled with 99mTc was constructed successfully. The molecular probe has the better labeling efficiency, stability and interference activity.The 99mTc-HYNIC -siRNA1026 could specificity accumulated in the tissue with CXCR4overexpression Key words:CXCR4; siRNA; T-47D cells; 99mTc
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Xu, P. Tags: Technologist Poster Session Source Type: research

Fluciclovine (18F) is a marker for high-affinity glutamine transporter ASCT2-mediated amino acid transport in breast cancer
Conclusion: Unlike prostate cancer, fluciclovine appears to be predominantly transported by the high-affinity glutamine transporter ASCT2 in breast cancer. This raises the potential for future clinical use in imaging response to inhibitors of glutamine metabolism, ASCT2 and pathways which regulate ASCT2. Research support: CRUK/EPSRC Cancer Imaging Centre in Oxford, Blue Earth Diagnostics Ltd
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Teoh, E., Morotti, M., Bridges, E., Jones, D., Miar, A., Wigfield, S., Zois, C., Gleeson, F., Harris, A. Tags: Oncology: Basic, Translational & amp; Therapy (Basic Science) Posters Source Type: research

Role of Adenine Nucleotide Translocase2 on the 18F-FDG uptake and differentiation in cancer
Conclusion: ANT2 expression correlated with FDG uptake in the various cancer cell lines. Higher level of ANT2 expression was observed in dedifferentiated cancer, and this indicates that ANT2 can be used as a marker of malignancy in various cancer. Research Support:
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lee, C.-H., Youn, H., Kim, M. J., Chai, Y. J., Cho, S. W., Kang, K. W., Chung, J.-K. Tags: Radiochemistry: Imaging of Cancer Source Type: research

Increased 18F-FDGuptake on PET in hepatocellular carcinoma is associated with level ofPDL1 expression that regulated by beta-catenin
Conclusion: The above results demonstrate that 18F-FDG PET/CT is closely related to the expression of PDL1 in HCC, and it is an important criterion that not only predicts the anti-cancer response of anti-PDL1 immunotherapy through that 18F-FDG PET/CT but also reflects the prognosis Research Support: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2011-0030086) and and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2016R1E1A1A01943303) and h was supported by the Basic Science Rese...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., Kim, Y. S., Yun, M. Tags: Radiotherapy and Monitoring Therapy Source Type: research

Expression of adenine nucleotide translocase2 regulates 18F-FDG accumulation in thyroid cancer cells
Conclusions We showed that ANT2 expression is related with FDG uptake in the thyroid carcinoma cells by modulating ANT2 expression. Also we showed correlation between ANT2 expression and thyroid cancer stage. Our result suggests that the evaluation of ANT2 expression can be used as a possible prognostic marker for FDG PET positive tumor.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Lee, C.-H., Kim, M. J., Youn, H., Kang, K. W., Chung, J.-K. Tags: MTA I: Basic Science Posters Source Type: research

The role of monocarboxylate transpoter 1 to uptake acetate in low glycolytic hepatocellular carcinoma cell line HepG2 cells
Conclusions Our data demonstrate that acetate was supported to HCC cells through MCT1 specifically in the low glycolytic cancer cells, and high MCT1 expression is related with low glycolytic phenotype cancer that would be the therapeutic target or diagnosis probe for low glycolytic cancers.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., kim, j., Yun, M. Tags: MTA I: Basic Science Posters Source Type: research

Construction and characterization of cRGD-modified 9-arginine peptide as a novel vector for targeted siRNA delivery
Conclusions The chimaeric peptide of c(RGD)2-9R is considered to be an effective siRNA delivery vector in vitro, and a hopeful application in vivo needs further examination.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Liu, M., Chen, X., Wang, R., Yan, P., Zhang, C. Tags: MTA I: Basic Science Posters Source Type: research