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Total 281 results found since Jan 2013.

Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo.
Abstract Targeted tumor imaging and efficient specific gene delivery in vivo has been one of the main challenges in gene-based cancer diagnosis and therapy. Herein, we engineered a citric acid-based polymer with intrinsical photoluminescence and gene loading capacity to achieve targeted delivery of siRNA and tumor imaging in vitro and in vivo. The multifunctional platform was formed from the self-assembling of poly (citric acid)-polymine conjugated with folic acid and rhodamine B (PPFR). PPFR showed stable photoluminescent ability and could effectively bind and protect the siRNA against RNase degradation. PPFR als...
Source: Biomaterials - February 2, 2019 Category: Materials Science Authors: Wang M, Guo Y, Xue Y, Niu W, Chen M, Ma PX, Lei B Tags: Biomaterials Source Type: research

ASAP Engineered Histidine-Enriched Facial Lipopeptides for Enhanced Intracellular Delivery of Functional siRNA to Triple Negative Breast Cancer Cells
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b13794
Source: ACS Applied Materials and Interfaces - January 24, 2019 Category: Materials Science Authors: Abhijit Biswas, Kasturee Chakraborty, Chiranjit Dutta, Sanchita Mukherjee, Paramita Gayen, Somnath Jan, Argha Mario Mallick, Dhananjay Bhattacharyya, Rituparna Sinha Roy Source Type: research

ASAP ROS-Sensitive Cross-Linked Polyethylenimine for Red-Light-Activated siRNA Therapy
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b18697
Source: ACS Applied Materials and Interfaces - January 4, 2019 Category: Materials Science Authors: Junxia Wang, Xinyu He, Song Shen, Ziyang Cao, Xianzhu Yang Source Type: research

Auto-fluorescent polymer nanotheranostics for self-monitoring of cancer therapy via triple-collaborative strategy.
Abstract Aberrant regulation of angiogenesis supply sufficient oxygen and nutrients to exacerbate tumor progression and metastasis. Taking this hallmark of cancer into account, reported here is a self-monitoring and triple-collaborative therapy system by auto-fluorescent polymer nanotheranostics which could be concurrently against angiogenesis and tumor cell growth by combining the benefits of anti-angiogenesis, RNA interfere and photothermal therapy (PTT). Auto-fluorescent amphiphilic polymer polyethyleneimine-polylactide (PEI-PLA) with positive charge can simultaneously load hydrophobic antiangiogenesis agent co...
Source: Biomaterials - December 20, 2018 Category: Materials Science Authors: Shao L, Li Q, Zhao C, Lu J, Li X, Chen L, Deng X, Ge G, Wu Y Tags: Biomaterials Source Type: research

Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts
This study shows that chemical hypoxia originating from HIF‐1α upregulation within the periprosthetic tissue is related to cobalt wear debris and highlights TRPM7 as an important key mediator in this context. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 00B: 0 00–000, 2018.
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - December 3, 2018 Category: Materials Science Authors: Constantin R ömmelt, Thomas Munsch, Andreas Drynda, Volkmar Lessmann, Christoph H. Lohmann, Jessica Bertrand Tags: Original Research Reports Source Type: research

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness.
Abstract Desmoplasia is a hallmark of pancreatic cancer and consists of fibrotic cells and secreted extracellular matrix (ECM) components. Various in vitro three-dimensional (3D) models of desmoplasia have been reported, but little is known about the relevant thickness of the engineered fibrotic tissue. We thus measured the thickness of fibrotic tissue in human pancreatic cancer, as defined by the distance from the blood vessel wall to tumor cells. We then generated a 3D fibrosis model with a thickness reaching the clinically observed range using pancreatic stellate cells (PSCs), the main cellular constituent of p...
Source: Biomaterials - November 17, 2018 Category: Materials Science Authors: Tanaka HY, Kitahara K, Sasaki N, Nakao N, Sato K, Narita H, Shimoda H, Matsusaki M, Nishihara H, Masamune A, Kano MR Tags: Biomaterials Source Type: research

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights
Publication date: December 2018Source: Materials Today Communications, Volume 17Author(s): Kumar Janakiraman, Venkateshwaran Krishnaswami, Vijaya Rajendran, Subramanian Natesan, Ruckmani KandasamyAbstractRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and IL-10...
Source: Materials Today Communications - October 4, 2018 Category: Materials Science Source Type: research

ASAP Charge and Assembly Reversible Micelles Fueled by Intracellular ATP for Improved siRNA Transfection
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b13300
Source: ACS Applied Materials and Interfaces - September 17, 2018 Category: Materials Science Authors: Zhanwei Zhou, Chenzi Li, Minghua Zhang, Qingyan Zhang, Chenggen Qian, David Oupicky, Minjie Sun Source Type: research

Novel Nano therapeutic materials for the effective treatment of Rheumatoid Arthritis- recent insights
Publication date: Available online 15 September 2018Source: Materials Today CommunicationsAuthor(s): Kumar Janakiraman, Venkateshwaran Krishnaswami, Vijaya Rajendran, Subramanian Natesan, Ruckmani KandasamyAbstractRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8,...
Source: Materials Today Communications - September 15, 2018 Category: Materials Science Source Type: research

ASAP pH-Sensitive Nanocarrier-Mediated Codelivery of Simvastatin and Noggin siRNA for Synergistic Enhancement of Osteogenesis
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b10521
Source: ACS Applied Materials and Interfaces - August 16, 2018 Category: Materials Science Authors: Jinsheng Huang, Chaowen Lin, Jintao Fang, Xiaoxia Li, Jin Wang, Shaohui Deng, Sheng Zhang, Wanhan Su, Xiaoreng Feng, Bin Chen, Du Cheng, Xintao Shuai Source Type: research

Polyester-based nanoparticles for nucleic acid delivery
Publication date: Available online 25 July 2018Source: Materials Science and Engineering: CAuthor(s): Jing Zhao, Guojun Weng, Jianjun Li, Jian Zhu, Junwu ZhaoAbstractGene therapy is promising for the treatment of inherited diseases and complex diseases such as chronic infections and cancer. The advancement in science and technology has extended the scope of gene therapy from gene transfer to the delivery of a variety of nucleic acids such as mRNA, antisense oligonucleotides (ASOs), siRNA and miRNA. Nanoparticle delivery systems can efficiently protect the nucleic acids from enzymatic degradation and immune recognition, fac...
Source: Materials Science and Engineering: C - July 26, 2018 Category: Materials Science Source Type: research

ASAP Thiol-Epoxy “Click” Chemistry to Engineer Cytocompatible PEG-Based Hydrogel for siRNA-Mediated Osteogenesis of hMSCs
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b07167
Source: ACS Applied Materials and Interfaces - July 23, 2018 Category: Materials Science Authors: Cong Truc Huynh, Fangze Liu, Yuxuan Cheng, Katherine A. Coughlin, Eben Alsberg Source Type: research

ASAP Improved Cell Transfection of siRNA by pH-Responsive Nanomicelles Self-Assembled with mPEG- < italic toggle="yes" > b < /italic > -PHis- < italic toggle="yes" > b < /italic > -PEI Copolymers
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b04301
Source: ACS Applied Materials and Interfaces - June 19, 2018 Category: Materials Science Authors: Bin Xu, Yuan-Jun Zhu, Cheng-Han Wang, Chong Qiu, Jing Sun, Yi Yan, Xin Chen, Jian-Cheng Wang, Qiang Zhang Source Type: research

ASAP Biodegradable Black Phosphorus Nanosheets Mediate Specific Delivery of hTERT siRNA for Synergistic Cancer Therapy
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b04807
Source: ACS Applied Materials and Interfaces - June 15, 2018 Category: Materials Science Authors: Lei Chen, Chuan Chen, Wei Chen, Ke Li, Xiaozhen Chen, Xudong Tang, Ganfeng Xie, Xi Luo, Xiaojiao Wang, Houjie Liang, Songtao Yu Source Type: research