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Total 281 results found since Jan 2013.
An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy
Biomaterials. 2022 Jun 22;287:121645. doi: 10.1016/j.biomaterials.2022.121645. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with a high mortality rate. Immunotherapy has achieved promising clinical results in multiple cancers, but shows unsatisfactory outcome in GBM patients, and poor drug delivery across the blood-brain barrier (BBB) is believed to be one of the main limitations that hinder the therapeutic efficacy of drugs. Herein, a new cationic lipid nanoparticle (LNP) that can efficiently deliver siRNA across BBB and target mouse brain is prepared fo...
Source: Biomaterials - July 2, 2022 Category: Materials Science Authors: Shuhan Liu Ji Liu Haisong Li Kuirong Mao Haorui Wang Xiandi Meng Jialiang Wang Chenxi Wu Hongmei Chen Xin Wang Xiuxiu Cong Yue Hou Ye Wang Ming Wang Yong-Guang Yang Tianmeng Sun Source Type: research
ASAP Liposomal Co-delivery of PD-L1 siRNA/Anemoside B4 for Enhanced Combinational Immunotherapeutic Effect
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c01123
Source: ACS Applied Materials and Interfaces - June 21, 2022 Category: Materials Science Authors: Xiang Li, Xiong Zhou, Jun Liu, Jing Zhang, Yulin Feng, Fang Wang, Yao He, Anping Wan, Nina Filipczak, Satya Siva Kishan Yalamarty, Yi Jin, and Vladimir P. Torchilin Source Type: research
Non-viral siRNA delivery to T cells: Challenges and opportunities in cancer immunotherapy
Biomaterials. 2022 Apr 5;286:121510. doi: 10.1016/j.biomaterials.2022.121510. Online ahead of print.ABSTRACTT lymphocytes are the major drivers of antitumor immunity. The recent clinical success of adoptive T cell therapies and immune checkpoint inhibitors has demonstrated the strength of modulating T cell function in fighting cancer. Nonetheless, a significant fraction of patients remain unresponsive largely due to the immunosuppressive tumor environment that blunts T cell activity. Small interfering RNAs (siRNAs) offer the potential to sequence-specifically silence the expression of negative regulator genes in T cells in...
Source: Biomaterials - May 24, 2022 Category: Materials Science Authors: Jelter Van Hoeck Kevin Braeckmans Stefaan C De Smedt Koen Raemdonck Source Type: research
Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury
Biomaterials. 2022 May 2;285:121562. doi: 10.1016/j.biomaterials.2022.121562. Online ahead of print.ABSTRACTAcute kidney injury (AKI) is characterized by a sudden decrease in renal function and impacts growing number of people worldwide. RNA interference (RNAi) showed potential to treat diseases with no or limited conventional therapies, including AKI. Suitable carriers are needed to protect and selectively deliver RNAi to target cells to fully explore this therapeutic modality. Here, we report on the synthesis of chitosan modified with α-cyclam-p-toluic acid (C-CS) as a novel siRNA carrier for targeted delivery to injure...
Source: Biomaterials - May 13, 2022 Category: Materials Science Authors: Weimin Tang Sudipta Panja Chinmay M Jogdeo Siyuan Tang Ling Ding Ao Yu Kirk W Foster Del L Dsouza Yashpal S Chhonker Heather Jensen-Smith Hee-Seong Jang Erika I Boesen Daryl J Murry Babu Padanilam David Oupick ý Source Type: research
A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction
Biomaterials. 2022 Apr 28;285:121541. doi: 10.1016/j.biomaterials.2022.121541. Online ahead of print.ABSTRACTObesity is the major risk factor for metabolic diseases such as fatty liver, hyperlipidemia and insulin resistance. Beige fat has been recognized as a therapeutic target considering its great potential to burn energy. Since the evolutionary discovery of RNA interference and its utilization for gene knockdown in mammalian cells, a remarkable progress has been achieved in siRNA-based therapeutics. However, efficient delivery of siRNA into adipose tissues or differentiated adipocytes is challenging due to high lipid co...
Source: Biomaterials - May 9, 2022 Category: Materials Science Authors: Jin Qiu Qianqian Fan Sainan Xu Dongmei Wang Juntong Chen Sainan Wang Tianhui Hu Xinran Ma Yiyun Cheng Lingyan Xu Source Type: research
Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth
Biomaterials. 2022 Apr 23;285:121539. doi: 10.1016/j.biomaterials.2022.121539. Online ahead of print.ABSTRACTLung cancer is a major contributor to cancer-related death worldwide. siRNA nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to overcome to increase siRNA delivery to solid tumors, including penetration of nanoparticles into a complex microenvironment following systemic delivery while avoiding rapid clearance by the reticuloendothelial system, and limited siRNA release from endosomes once inside the cell. Here we characterized cell uptake, intracellular trafficking, and gene si...
Source: Biomaterials - May 2, 2022 Category: Materials Science Authors: Z Ma S W Wong H Forgham L Esser M Lai M N Leiske K Kempe G Sharbeen J Youkhana F Mansfeld J F Quinn P A Phillips T P Davis M Kavallaris J A McCarroll Source Type: research
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment
In this study, we successfully constructed a programmed site-specific delivery nanosystem for the combined delivery of transforming growth factor beta (TGF-β) receptor inhibitor LY3200882 (LY) and PD-L1 siRNA (siPD-L1) to boost anti-tumor immunotherapy. As expected, LY in the outer layer of the nanosystem was released by stimulation of MMP2, and dramatically down-regulated the expression of extracellular matrix (ECM) in the tumor-associated fibroblasts (TAFs), and thus promoted the infiltration of effector T cells and penetration of nanomedicines. Simultaneously, the blockade of TGF-β by LY also triggered immunogenic cel...
Source: Biomaterials - April 24, 2022 Category: Materials Science Authors: Pan Zhang Chao Qin Nan Liu Xinyuan Zhou Xuxin Chu Fangnan Lv Yongwei Gu Lifang Yin Jiyong Liu Jianping Zhou Meirong Huo Source Type: research
Synergetic regulation of kupffer cells, extracellular matrix and hepatic stellate cells with versatile CXCR4-inhibiting nanocomplex for magnified therapy in liver fibrosis
Biomaterials. 2022 Mar 29;284:121492. doi: 10.1016/j.biomaterials.2022.121492. Online ahead of print.ABSTRACTHepatic stellate cell (HSC)-targeted delivery is an attractive strategy for liver fibrosis therapy, but the efficacy is hampered by poor delivery of nanomaterials and complicated microenvironments of the fibrotic liver. Here, we report a versatile CXCR4-inhibiting nanocomplex composed of polymeric CXCR4 antagonism (PAMD, PA), CLD (clodronate) and siPAI-1 (siRNA of plasminogen activator inhibitor-1) that surmounts multiple barriers to improve the outcome by co-regulating Kupffer cells (KCs), extracellular matrix (ECM...
Source: Biomaterials - April 8, 2022 Category: Materials Science Authors: Pengkai Wu Xinping Luo Meiling Sun Beicheng Sun Minjie Sun Source Type: research
ATP-exhausted nanocomplexes for intratumoral metabolic intervention and photoimmunotherapy
Biomaterials. 2022 Mar 29;284:121503. doi: 10.1016/j.biomaterials.2022.121503. Online ahead of print.ABSTRACTTumor cells reprogram the metabolic pathways to acquire abundant nutrients and sustain malignant proliferation. This fierce metabolic competition in tumor ecosystem has been uncovered to be associated with tumor microenvironmental immunosuppression. Here we develop an adenosine triphosphate (ATP)-exhausted nanocomplex (IR@ZIF-RGD) to intervene in tumor energy metabolism and regulate tumor immune microenvironment. IR@ZIF-RGD could effectively deplete intracellular ATP and inhibit ATP synthesis by ATP-responsive ZIF-9...
Source: Biomaterials - April 3, 2022 Category: Materials Science Authors: Mian Yu Weiwei Zeng Yaqi Ouyang Shu Liang Yunfei Yi Huisong Hao Jiayin Yu Yang Liu Yichu Nie Tianqi Wang Yang Deng Meiying Wu Source Type: research
Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure
Biomaterials. 2022 Feb 18;283:121421. doi: 10.1016/j.biomaterials.2022.121421. Online ahead of print.ABSTRACTAutologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital heart disease (CHD). However, autologous cell therapies suffer from low cell retention following injection and patient-to-patient variability in cell quality. Here, we demonstrate how computational methods can be used to identify mechanisms of cardiac-derived c-Kit+ cell (CPC) reparative capacity and how biomaterials can be designed to improve cardiac patch perf...
Source: Biomaterials - February 26, 2022 Category: Materials Science Authors: Benjamin W Streeter Milton E Brown Preety Shakya Hyun-Ji Park Jichuan Qiu Younan Xia Michael E Davis Source Type: research
