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Specialty: Materials Science
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Total 281 results found since Jan 2013.
Synchronous targeted delivery of TGF- β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Biomaterials. 2023 Jul 25;301:122253. doi: 10.1016/j.biomaterials.2023.122253. Online ahead of print.ABSTRACTThe poor permeability of therapeutic drugs, limited T-cell infiltration, and strong immunosuppressive tumor microenvironment of triple-negative breast cancer (TNBC) acts as a prominent barrier to the delivery of drugs and immunotherapy including programmed cell death ligand-1 antibody (anti-PD-L1). Transforming growth factor (TGF)-β, an important cytokine produced by cancer-associated fibroblasts (CAFs) and tumor cells contributes to the pathological vasculature, dense tumor stroma and strong immunosuppressive tumo...
Source: Biomaterials - August 3, 2023 Category: Materials Science Authors: Mengmeng Yang Chao Qin Linlin Tao Gang Cheng Jingjing Li Fangnan Lv Nan Yang Zuhang Xing Xinyu Chu Xiaopeng Han Meirong Huo Lifang Yin Source Type: research
ASAP Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of < italic toggle="yes" > KRAS < /italic > -Mutant Non-Small-Cell Lung Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c05007
Source: ACS Applied Materials and Interfaces - June 24, 2023 Category: Materials Science Authors: Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, and Xue-Qing Zhang Source Type: research
ASAP β‑Glucan-Mediated Oral Codelivery of 5FU and Bcl2 siRNA Attenuates Stomach Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c03528
Source: ACS Applied Materials and Interfaces - June 23, 2023 Category: Materials Science Authors: Humayra Afrin, Stephanie Vargas Esquivel, Raj Kumar, Md Ikhtiar Zahid, Ikhtiar Zahid, Beu Oporeza, Md Fashiar Rahman, Thomas Boland, and Md Nurunnabi Source Type: research
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Biomaterials. 2023 May 15;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Online ahead of print.ABSTRACTTherapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver TNA efficiently and safely both in vitro and in vivo. Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as to whether...
Source: Biomaterials - May 27, 2023 Category: Materials Science Authors: Yue Qin Adam A Walters Nadia Rouatbi Julie Tzu-Wen Wang Hend Mohamed Abdel-Bar Khuloud T Al-Jamal Source Type: research
Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation
This study provides a sophisticated method for HSC-targeting cytoplasmic RNA delivery using endogenous ligand hijacking and dual sensitivity of ROS and cis diol compounds.PMID:37167895 | DOI:10.1016/j.biomaterials.2023.122134
Source: Biomaterials - May 11, 2023 Category: Materials Science Authors: Jinsheng Huang Huiling Huang Yiyao Wang Bin Xu Minzhao Lin Shisong Han Yuanyuan Yuan Yong Wang Xintao Shuai Source Type: research
Transfection efficacy and drug release depends upon the PEG derivative in cationic lipoplexes: Evaluation in 3D in vitro model and in vivo
AbstractThe goal of the study was to estimate transfection efficacy and drug release in function of the PEG derivative in cationic liposomes and lipoplexes in both 2D and 3D in vitro models as well as in a mouse model (in vivo). For this purpose, cationic PEGylated nanocarriers based on OrnOrnGlu(C16H33)2 lipopeptides were fabricated and characterized. The nanocarriers were loaded with DNA plasmid pGL3 or with siRNA targeting 5 ′-UTR region of Hepatitis C virus, and their transfection efficacies were studied by luciferase test or by PCR technique, respectively. The pGL3-lipoplexes containing PEG derivativeb (6 mol % P...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 4, 2023 Category: Materials Science Authors: Gileva A. M.,
Koloskova O. O.,
Nosova A. S.,
Vishniakova L. I.,
Simonova V. A.,
Kurbanova L. A.,
Egorenkov E. A.,
Smirnov V. V.,
Budanova U. A.,
Sebyakin Yu L.,
Suzina N. E.,
Khaitov M. R.,
Markvicheva E. Tags: RESEARCH ARTICLE Source Type: research
Core polymer optimization of ternary siRNA nanoparticles enhances in vivo safety, pharmacokinetics, and tumor gene silencing
Biomaterials. 2023 Mar 28;297:122098. doi: 10.1016/j.biomaterials.2023.122098. Online ahead of print.ABSTRACTGene silencing with siRNA nanoparticles (si-NPs) is promising but still clinically unrealized for inhibition of tumor driver genes. Ternary si-NPs containing siRNA, a single block NP core-forming polymer poly[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)] (DMAEMA-co-BMA, 50B), and an NP surface-forming diblock polymer 20 kDa poly(ethylene glycol)-block-50B (20kPEG-50B) have the potential to improve silencing activity in tumors due to the participation of both 50B and 20kPEG-50B in siRNA electrostatic...
Source: Biomaterials - April 9, 2023 Category: Materials Science Authors: Shrusti S Patel Ella N Hoogenboezem Fang Yu Carlisle R DeJulius R Brock Fletcher Alex G Sorets Fiona K Cherry Justin H Lo Mariah G Bezold Nora Francini Richard d'Arcy Jordan E Brasuell Rebecca S Cook Craig L Duvall Source Type: research
ASAP Artificial Base-Directed < italic toggle="yes" > In Vivo < /italic > Assembly of an Albumin –siRNA Complex for Tumor-Targeting Delivery
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c19075
Source: ACS Applied Materials and Interfaces - February 8, 2023 Category: Materials Science Authors: Yang Sun, Die Yu, Xinyao Geng, Ding Ding, Yu Yang, Zhuang Liu, Zeyu Xiao, Ruowen Wang, and Weihong Tan Source Type: research
ASAP Silencing the Catalase Gene with SiRNA for Enhanced Chemodynamic Therapy
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c20144
Source: ACS Applied Materials and Interfaces - February 8, 2023 Category: Materials Science Authors: Ying Liu, Xin Wang, Hanjun Chen, Tingting Wu, Yu Cao, and Zhihong Liu Source Type: research
Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells
Biomaterials. 2023 Jan 21;294:122016. doi: 10.1016/j.biomaterials.2023.122016. Online ahead of print.ABSTRACTTargeted delivery of oligonucleotides or small molecular drugs to hepatocytes, the liver's parenchymal cells, is challenging without targeting moiety due to the highly efficient mononuclear phagocyte system (MPS) of the liver. The MPS comprises Kupffer cells and specialized sinusoidal endothelial cells, efficiently clearing nanocarriers regardless of their size and surface properties. Physiologically, this non-parenchymal shield protects hepatocytes; however, these local barriers must be overcome for drug delivery. ...
Source: Biomaterials - January 26, 2023 Category: Materials Science Authors: WanLing Foo Zolt án Cseresnyés Carsten R össel Yingfeng Teng Anuradha Ramoji Mingzhe Chi Walter Hauswald Sophie Huschke Stephanie Hoeppener J ürgen Popp Felix H Schacher Marek Sierka Marc Thilo Figge Adrian T Press Michael Bauer Source Type: research
