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Specialty: Materials Science
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Total 281 results found since Jan 2013.
ASAP Overcoming Multidrug Resistance by Codelivery of MDR1-Targeting siRNA and Doxorubicin Using EphA10-Mediated pH-Sensitive Lipoplexes: In Vitro and In Vivo Evaluation
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b01806
Source: ACS Applied Materials and Interfaces - June 13, 2018 Category: Materials Science Authors: Jiulong Zhang, Zhouqi Du, Shuang Pan, Menghao Shi, Jie Li, Chunrong Yang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao Source Type: research
ASAP Hierarchical Assembly of siRNA with Tetraamino Fullerene in Physiological Conditions for Efficient Internalization into Cells and Knockdown
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b01869
Source: ACS Applied Materials and Interfaces - May 30, 2018 Category: Materials Science Authors: Kosuke Minami, Koji Okamoto, Koji Harano, Eisei Noiri, Eiichi Nakamura Source Type: research
ASAP Theranostic Niosomes for Efficient siRNA/MicroRNA Delivery and Activatable Near-Infrared Fluorescent Tracking of Stem Cells
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b05513
Source: ACS Applied Materials and Interfaces - May 29, 2018 Category: Materials Science Authors: Chuanxu Yang, Shan Gao, Ping Song, Frederik Dagn æs-Hansen, Maria Jakobsen, Jørgen Kjems Source Type: research
The study of relationships between pKa value and siRNA delivery efficiency based on tri-block copolymers.
Abstract
Tri-block copolymers have exhibited great potentials in small interfering RNA (siRNA) therapeutics. To reveal structure-activity relationships, we here synthesized a series of tri-block copolymers with different hydrophobic segments, PEG-PAMA-P(C6Ax-C7Ay-DPAz-DBAm) (EAAS) and PEG-PDAMAEMA-P(C6Ax-C7Ay-DPAz-DBAm) (EDAS), termed from EAASa to EAASh and EDASa to EDASh, with pKa ranging from 5.2 to 7.0. Our data showed that the better gene silencing efficiency was located in pKa of 5.8-6.2, which was contributed from higher endosomal escape observed with confocal images and hemolysis assay. EAASc, the leader p...
Source: Biomaterials - May 29, 2018 Category: Materials Science Authors: Du L, Wang C, Meng L, Cheng Q, Zhou J, Wang X, Zhao D, Zhang J, Deng L, Liang Z, Dong A, Cao H Tags: Biomaterials Source Type: research
Delivery of small interfering RNA against Nogo-B receptor via tumor-acidity responsive nanoparticles for tumor vessel normalization and metastasis suppression.
This study demonstrated that NgBR is a promising therapeutic target in abnormal tumor vasculature and aggressive cancer cells, and the tumor-responsive nanoparticle with the feature of charge transformation offers great potential for tumor-specific delivery of gene therapeutics.
PMID: 29803999 [PubMed - as supplied by publisher]
Source: Biomaterials - May 21, 2018 Category: Materials Science Authors: Wang B, Ding Y, Zhao X, Han X, Yang N, Zhang Y, Zhao Y, Zhao X, Taleb M, Miao QR, Nie G Tags: Biomaterials Source Type: research
Glycogen-nucleic acid constructs for gene silencing in multicellular tumor spheroids.
Abstract
The poor penetration of nanocarrier-siRNA constructs into tumor tissue is a major hurdle for the in vivo efficacy of siRNA therapeutics, where the ability of the constructs to permeate the 3D multicellular matrix is determined by their physicochemical properties. Herein, we optimized the use of soft glycogen nanoparticles for the engineering of glycogen-siRNA constructs that can efficiently penetrate multicellular tumor spheroids and exert a significant gene silencing effect. Glycogen nanoparticles from different bio-sources and with different structural features were investigated. We show that larger gl...
Source: Biomaterials - May 20, 2018 Category: Materials Science Authors: Wojnilowicz M, Besford QA, Wu YL, Loh XJ, Braunger JA, Glab A, Cortez-Jugo C, Caruso F, Cavalieri F Tags: Biomaterials Source Type: research
Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer.
Abstract
To improve the non-invasive therapeutic efficacy for ER positive breast cancer (ER+ BC), we fabricated a multifunctional FOXA1 loaded porphyrin microbubble to combine photodynamic therapy (PDT) and gene therapy of FOXA1 knockdown (KD) with ultrasound targeted microbubble destruction (UTMD) technology under the guidance of contrast enhanced ultrasound (CEUS). Cationic porphyrin microbubbles (CpMBs) were firstly fabricated from a porphyrin grafted lipid with two cationic amino groups (PGL-NH2) and fluorocarbon inert gas of C3F8. Porphyrin group in the CpMBs monolayer could be used as a photosensitizer for ...
Source: Biomaterials - May 3, 2018 Category: Materials Science Authors: Zhao R, Liang X, Zhao B, Chen M, Liu R, Sun S, Yue X, Wang S Tags: Biomaterials Source Type: research
ASAP Design of Mannose-Functionalized Curdlan Nanoparticles for Macrophage-Targeted siRNA Delivery
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b02073
Source: ACS Applied Materials and Interfaces - April 19, 2018 Category: Materials Science Authors: Tsogzolmaa Ganbold, Huricha Baigude Source Type: research
ASAP Stable Dispersions of Covalently Tethered Polymer Improved Graphene Oxide Nanoconjugates as an Effective Vector for siRNA Delivery
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b03477
Source: ACS Applied Materials and Interfaces - April 17, 2018 Category: Materials Science Authors: Nisha Yadav, Naveen Kumar, Peeyush Prasad, Shivani Shirbhate, Seema Sehrawat, Bimlesh Lochab Source Type: research
Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide
Publication date: 1 June 2018 Source:Materials Science and Engineering: C, Volume 87 Author(s): Chen Fu, Yonggang Xiang, Xiaorong Li, Ailing Fu For successful theranosis of brain diseases, limited access of therapeutic molecules across blood-brain barrier (BBB) needs be overcome in brain delivery. Currently, peptide derivatives of rabies virus glycoprotein (RVG) have been exploited as delivery ligands to transport nanocarriers across BBB and specifically into the brain. The targeting peptides usually conjugate to the nanocarrier surface, and the cargoes, including siRNA, miRNA, DNA, proteins and small molecular chemicals,...
Source: Materials Science and Engineering: C - March 17, 2018 Category: Materials Science Source Type: research
Noncovalent tagging of siRNA with steroids for transmembrane delivery.
Abstract
Short interfering RNA (siRNA) has broad applications in biology and medicine, and holds tremendous potential to become a new class of therapeutics for many diseases. As a highly anionic macrobiomolecule, its cytosolic delivery, however, has been a major roadblock in translation. Here, we report the development of small, bifunctional chemical tags capable of transporting siRNA directly into the cytosol. The bifunctional tags consist of a siRNA-binding moiety that interacts with siRNA non-covalently, and a steroid domain that readily fuses with the mammalian cell membrane. In contrast to the conventional co...
Source: Biomaterials - February 3, 2018 Category: Materials Science Authors: Tai W, Gao X Tags: Biomaterials Source Type: research
Dual-responsive polyplexes with enhanced disassembly and endosomal escape for efficient delivery of siRNA.
Abstract
Despite the extracellular barriers for siRNA delivery have been overcome by utilizing advanced nanoparticle delivery systems, the key intracellular barriers after internalization including efficient disassembly of siRNA and endosomal escape still remains challenging. To address the issues, we developed a unique pH- and redox potential-responsive polyplex delivery system based on the copolymer of mPEG-b-PLA-PHis-ssPEI1.8 k, which is composed of a pH-responsive copolymer of PEG-b-PLA-PHis (Mw 5 k) and a branched PEI (Mw1.8 k) linked with redox cleavable disulfide bond. The copolymer showed excellent s...
Source: Biomaterials - February 3, 2018 Category: Materials Science Authors: Zhu J, Qiao M, Wang Q, Ye Y, Ba S, Ma J, Hu H, Zhao X, Chen D Tags: Biomaterials Source Type: research
Comparison
of Biological Responses of Polymers Based
on Imine and Disulfide Backbones for siRNA Delivery
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.7b16101
Source: ACS Applied Materials and Interfaces - January 31, 2018 Category: Materials Science Authors: Junyi Che, Yonger Xue, Jia Feng, Guang Bai and Weien Yuan Source Type: research
Branched
Glycerol-Based Copolymer with Ultrahigh p65
siRNA Delivery Efficiency for Enhanced Cancer Therapy
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.7b17109
Source: ACS Applied Materials and Interfaces - January 24, 2018 Category: Materials Science Authors: Li Zhou, Xiaoyan Qu, Yi Guo, Min Wang, Bo Lei and Peter X. Ma Source Type: research
siRNA
Delivery Using a Cationic-Lipid-Based Highly Selective Human DNA Ligase
I Inhibitor
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.7b19193
Source: ACS Applied Materials and Interfaces - January 2, 2018 Category: Materials Science Authors: Surendar R. Bathula, Komal Sharma, Deependra K. Singh, Muktapuram P. Reddy, Pushpa R. Sajja, Amit L. Deshmukh and Dibyendu Banerjee Source Type: research
