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Total 281 results found since Jan 2013.

Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure
Biomaterials. 2022 Feb 18;283:121421. doi: 10.1016/j.biomaterials.2022.121421. Online ahead of print.ABSTRACTAutologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital heart disease (CHD). However, autologous cell therapies suffer from low cell retention following injection and patient-to-patient variability in cell quality. Here, we demonstrate how computational methods can be used to identify mechanisms of cardiac-derived c-Kit+ cell (CPC) reparative capacity and how biomaterials can be designed to improve cardiac patch perf...
Source: Biomaterials - February 26, 2022 Category: Materials Science Authors: Benjamin W Streeter Milton E Brown Preety Shakya Hyun-Ji Park Jichuan Qiu Younan Xia Michael E Davis Source Type: research

ASAP Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c21997
Source: ACS Applied Materials and Interfaces - February 21, 2022 Category: Materials Science Authors: Ling Ding, Siyuan Tang, Ao Yu, Anlin Wang, Weimin Tang, Huizhen Jia, and David Oupicky ́ Source Type: research

ASAP Functionalized LbL Film for Localized Delivery of STAT3 siRNA and Oxaliplatin Combination to Treat Colon Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c22166
Source: ACS Applied Materials and Interfaces - February 16, 2022 Category: Materials Science Authors: Leela Sai Lokesh Janardhanam, Sony Priyanka Bandi, and Venkata Vamsi Krishna Venuganti Source Type: research

ASAP Combinational Chemoimmunotherapy for Breast Cancer by Codelivery of Doxorubicin and PD-L1 siRNA Using a PAMAM-Incorporated Liposomal Nanoplatform
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c21775
Source: ACS Applied Materials and Interfaces - February 9, 2022 Category: Materials Science Authors: Qing Hu, Jiayi Yao, Xiaoqin Wang, Yanfang Wang, Xiaoling Fu, Ju Ma, Han Lin, Jiaqi Xu, Longhua Shen, and Xiangbin Yu Source Type: research

Facile one-step synthesis of NIR-Responsive siRNA-Inorganic hybrid nanoplatform for imaging-guided photothermal and gene synergistic therapy
Biomaterials. 2022 Jan 31;282:121404. doi: 10.1016/j.biomaterials.2022.121404. Online ahead of print.ABSTRACTDiagnosis-guided synergistic treatment based on innovative nanomaterials is of great significance for the development of anti-cancer therapies. However, the low delivery efficiency of therapeutic gene and the inability to trigger release on demand are still major obstacles impeding its wide application. Herein, we report an ultra-fast one-step method within 2 min to prepare a smart carrier, liposome-coated Prussian blue @ gold nano-flower, which is named LPAR after linking with tumor-targeting peptide. The versatile...
Source: Biomaterials - February 8, 2022 Category: Materials Science Authors: Xiuna Jia Mengmeng Lv Yunwei Fei Qing Dong Hao Wang Qiong Liu Dan Li Jin Wang Erkang Wang Source Type: research

Intracellular Co-delivery of native antibody and siRNA for combination therapy by using biodegradable silica nanocapsules
Biomaterials. 2022 Jan 17;281:121376. doi: 10.1016/j.biomaterials.2022.121376. Online ahead of print.ABSTRACTCombination therapy is a promising strategy for treating multidrug-resistant (MDR) cancers. Macromolecules such as antibodies and RNAs have been successfully used for targeted therapy owing to their high specificity. However, their application as therapeutics remains limited due to membrane impermeability and poor intracellular stability. Designing drug delivery systems capable of co-administering macromolecules is therefore crucial for advancing them as therapeutics for combination therapy. Herein, by using glutath...
Source: Biomaterials - January 22, 2022 Category: Materials Science Authors: Peiyan Yuan Fen Yang Si Si Liew Jiachang Yan Xiao Dong Jinfeng Wang Shubo Du Xin Mao Liqian Gao Shao Q Yao Source Type: research

ASAP Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c23069
Source: ACS Applied Materials and Interfaces - January 21, 2022 Category: Materials Science Authors: Jiaojiao Zhu, Man Guo, Yanhui Cui, Yingcai Meng, Jinsong Ding, Wenbin Zeng, and Wenhu Zhou Source Type: research

Versatile fully biodegradable dendritic nanotherapeutics
Biomaterials. 2022 Jan 3;281:121356. doi: 10.1016/j.biomaterials.2021.121356. Online ahead of print.ABSTRACTThe repeated administration of non-degradable dendrimers can lead to toxicity due to their bioaccumulation. Furthermore, in drug delivery applications, carrier stability can result in low biological performance due to insufficient intracellular cargo release. A novel family of versatile, biosafe, water-soluble, and fully biodegradable PEG-dendritic nanosystems is proposed, which overcomes the limitations of the most used dendrimers. Their novelty relies on the full and adjustable degradability thanks to the presence ...
Source: Biomaterials - January 15, 2022 Category: Materials Science Authors: Victoria Leiro Ana Patr ícia Spencer Nat ália Magalhães Ana Paula P êgo Source Type: research

SHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy
Biomaterials. 2021 Dec 30;281:121359. doi: 10.1016/j.biomaterials.2021.121359. Online ahead of print.ABSTRACTThe near-perivascular accumulation in solid tumors and short-lived span in circulation, derails even the most competent nanoparticles (NPs) from achieving their maximum therapeutic potential. Moreover, delivering them across the blood brain/tumor barrier (BBB/BTB) is further challenging to sought anticancer effect. To address these key challenges, we designed a linearly aligned nucleic acid-complexed polydixylitol-based polymeric nanochains (X-NCs), with inherent hyperosmotic properties enabling transmigration of th...
Source: Biomaterials - January 8, 2022 Category: Materials Science Authors: Shambhavi Pandey Myung Chul Lee Jae Woon Lim Yun-Hoon Choung Kyoung-Je Jang Sang Bae Park Jae Eun Kim Jong Hoon Chung Pankaj Garg Source Type: research

ASAP siRNA Mediated GSK3 Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimers Disease Pathology: Evidence from In Vitro and In Vivo Studies
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c15305
Source: ACS Applied Materials and Interfaces - December 30, 2021 Category: Materials Science Authors: Smriti Gupta, Vishal Singh, Subramaniam Ganesh, Nitin K. Singhal, and Rajat Sandhir Source Type: research