Filtered By:
Specialty: Cytology
Therapy: Cancer Therapy

This page shows you your search results in order of date.

Order by Relevance | Date

Total 28 results found since Jan 2013.

Combination of B7H6-siRNA and temozolomide synergistically reduces stemness and migration properties of glioblastoma cancer cells
This study aimed to understand the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer. U87 cells were treated with B7H6-siRNA and temozolomide, separately and in combination. Cell viability, stemness, cell migration, and apoptosis were measured. The results of this work presented the synergistic effect of B7H6-siRNA and temozolomide in inhibiting the cancerous features of the U87 cell line. Down-regulating B7H6-siRNA expression inhibited the cell viability of U87 glioblastoma cancer cells and increased their sensitivity to temozolomide. In addition, a not...
Source: Experimental Cell Research - May 29, 2023 Category: Cytology Authors: Nadia Allahyarzadeh Khiabani Mohammad Amin Doustvandi Fateme Mohammadnejad Elnaz Salmani Hassan Kohal Neda Boushehri Mahdi Jafarlou Behzad Baradaran Source Type: research

MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
CONCLUSION: Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for non-small cell lung cancer therapy.PMID:36701842 | DOI:10.4143/crt.2022.1042
Source: Cell Research - January 26, 2023 Category: Cytology Authors: Yang Yang Rongfang Qiu Qiaoyou Weng Ziwei Xu Jingjing Song Siyu Zhao Miaomiao Meng Dengke Zhang Chunli Kong Hailin Wang Min Xu Zhongwei Zhao Jiansong Ji Source Type: research

C5 α secreted by tumor mesenchymal stem-like cells mediates resistance to 5-aminolevulinic acid-based photodynamic therapy against glioblastoma tumorspheres
CONCLUSIONS: Our results show substantial therapeutic effects of 5-ALA-based PDT on GBM TSs, suggesting C5α as a key molecule responsible for PDT resistance. These findings could trigger PDT as a standard clinical modality for the treatment of GBM.PMID:36107247 | DOI:10.1007/s00432-022-04347-w
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Junseong Park Seung Jae Oh Jin-Kyoung Shim Young Bin Ji Ju Hyung Moon Eui Hyun Kim Yong-Min Huh Jin-Suck Suh Jong Hee Chang Su-Jae Lee Seok-Gu Kang Source Type: research

Effects of indoleamine 2, 3-dioxygenase (IDO) silencing on immunomodulatory function and cancer promoting characteristic of adipose derived mesenchymal stem cells (ASCs)
This article is protected by copyright. All rights reserved.PMID:34498786 | DOI:10.1002/cbin.11698
Source: Cell Biology International - September 9, 2021 Category: Cytology Authors: Fahimeh Heidari Mahboobeh Razmkhah Vahid Razban Nasrollah Erfani Source Type: research

TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
CONCLUSION: TrkB/BDNF signaling may be a new therapeutic target for PDAC. Therapies targeting TrkB/BDNF signaling may be a conclusive cancer therapy for refractory solid cancer.PMID:34281873 | DOI:10.21873/anticanres.15205
Source: Cell Research - July 20, 2021 Category: Cytology Authors: Yasuhiro Oyama Shinjiro Nagao Lin Na Kosuke Yanai Masayo Umebayashi Katsuya Nakamura Shuntaro Nagai Akiko Fujimura Akio Yamasaki Kazunori Nakayama Takashi Morisaki Hideya Onishi Source Type: research

B7-H3 on breast cancer cell MCF7 inhibits IFN-gamma release from tumour-infiltrating T cells
Pathol Res Pract. 2021 May 5;224:153461. doi: 10.1016/j.prp.2021.153461. Online ahead of print.ABSTRACTB7-H3 is a type I membrane protein that has contradictory co-stimulatory and co-inhibitory effects in adaptive and anti-tumour immunity. B7-H3 is up-regulated in many malignant tumours, including breast cancer. Therefore, we hypothesise that B7-H3, which has an immunosuppressive role, suppresses anti-tumour immunity. The aim of this study was to clarify the role of B7-H3 in the tumor microenvironment in breast cancer, explore the possibility of B7-H3 as a target for clinical immunotherapy, and provide reference for clinic...
Source: Cell Research - July 15, 2021 Category: Cytology Authors: Lili Shao Qiongzhu Yu Rui Xia JiaYu Zhang Siyi Gu Daojiang Yu Zhixiang Zhuang Source Type: research

KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer
CONCLUSION: We conclude that KMT2C could serve as a potential biomarker of prognosis and chemotherapy sensitivity by affecting the DNA damage repair-related genes of breast cancer.PMID:34240274 | DOI:10.1007/s10549-021-06325-1
Source: Cell Research - July 9, 2021 Category: Cytology Authors: Xinhua Liu Rongfang Qiu Min Xu Miaomiao Meng Siyu Zhao Jiansong Ji Yang Yang Source Type: research

DAP1 negatively regulates autophagy induced by cardamonin in SKOV3 cells.
This study aimed to investigate whether it is relevant for DAP1 in proliferation inhibition and autophagy induced by cardamonin in tumor cells. Using online bioinformatics tools, we found that DAP1 expression is closely related to the survival of patients with ovarian cancer. Our study showed that autophagy induced by cardamonin was associated with mTOR inhibition, and DAP1 was involved in this process. Silence of DAP1 decreased cell proliferation but enhanced antiproliferative effect of cardamonin in SKOV3 cells. The level of autophagy was elevated by DAP1 silencing in SKOV3 cells. Notably, cardamonin showed higher autoph...
Source: Cell Biology International - July 23, 2020 Category: Cytology Authors: Nie X, Chen H, Niu P, Zhu Y, Zhou J, Jiang L, Li D, Lin M, Chen Z, Shi D Tags: Cell Biol Int Source Type: research

miR3609 sensitizes breast cancer cells to adriamycin by blocking the programmed death-ligand 1 immune checkpoint.
Abstract Chemoresistance is the leading cause of breast cancer therapy failure, and studies of the mechanisms underlying chemoresistance and the treatment of drug-resistant tumors remain challenging. In the present study, we discovered a novel microRNA, miR3609, that influences the malignancy of breast cancer. Our results showed miR-3609 expression was lower in resistant breast cancer cells than in sensitive breast cancer cells (MCF-7), while PD-L1 expression was higher in resistant breast cancer cells than in sensitive breast cancer cells. Co-transfection of a miR-3609 plasmid with a luciferase construct containi...
Source: Experimental Cell Research - March 19, 2019 Category: Cytology Authors: Li D, Wang X, Yang M, Kan Q, Duan Z Tags: Exp Cell Res Source Type: research

Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation
Conclusion: Our results demonstrate for the first time that AGP induces RASSF1A expression in colon cancer cells and is dependent on angiogenesis signaling events. Therefore, our research may facilitate novel therapeutic options for advanced colon cancer therapy.Cell Physiol Biochem 2018;48:1259 –1273
Source: Cellular Physiology and Biochemistry - July 25, 2018 Category: Cytology Source Type: research

Coroglaucigenin induces senescence and autophagy in colorectal cancer cells
ConclusionsOur results demonstrate that CGN induces senescence and autophagy in colorectal cancer cells and indicate that combining it with an autophagy inhibitor may be a novel strategy suitable for CGN‐mediated anti‐cancer therapy.
Source: Cell Proliferation - February 27, 2018 Category: Cytology Authors: Yong ‐Hao Huang, Jing Lei, Guo‐Hui Yi, Feng‐Ying Huang, Yue‐Nan Li, Cai‐Chun Wang, Yan Sun, Hao‐Fu Dai, Guang‐Hong Tan Tags: ORIGINAL ARTICLE Source Type: research

YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways
Conclusion: Collectively, our results demonstrate that Hippo-Yap can serve as a tumor promoter in human rectal cancer and acts by restricting JNK/Drp1/mitochondrial fission/ HtrA2/Omi, with potential implications for new approaches to human rectal cancer therapy.Cell Physiol Biochem 2017;44:2073 –2089
Source: Cellular Physiology and Biochemistry - December 14, 2017 Category: Cytology Source Type: research