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Specialty: Endocrinology
Education: Academia

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Total 16 results found since Jan 2013.

Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.
Abstract Extracellular vesicles (EVs) are key players of intercellular communication in physiological and pathological conditions. In cancer, EVs mediate complex signaling mechanisms between cancer cells and the tumor microenvironment, and can influence tumor progression and the response to existing therapies. Importantly, EVs can be loaded with therapeutic agents and modified to display tumor-targeting molecules. In the field of nanomedicine, EVs have been engineered to serve as therapeutic delivery vehicles for several anti-cancer agents, including antibodies, chemotherapy, compounds, CRISPR/Cas9 and siRNA. Nota...
Source: Endocrinology - January 7, 2021 Category: Endocrinology Authors: Kugeratski FG, McAndrews KM, Kalluri R Tags: Endocrinology Source Type: research

Interleukin-6 (IL-6) activates the NOTCH1 signaling pathway through E-proteins in endometriotic lesions.
CONCLUSIONS: IL-6 induced NOTCH1 expression is mediated by E-proteins in the ectopic GE cells, which may promote endometriotic lesion development. PMID: 32119078 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2020 Category: Endocrinology Authors: Song Y, Su RW, Joshi NR, Kim TH, Lessey BA, Jeong JW, Fazleabas AT Tags: J Clin Endocrinol Metab Source Type: research

Dihydrotestosterone increases cytotoxic activity of macrophages on prostate cancer cells via TRAIL.
Abstract Although androgen depravation therapy (ADT) and immunotherapy are potential treatment options in men with metastatic prostate cancer (CaP), androgen has conventionally been proposed to be a suppressor of the immune response. However, we herein report that dihydrotestosterone (DHT) activates macrophages. When the murine macrophage cell line (RAW 264.7), human monocyte (THP-1), and human peripheral blood monocytes were cultured with androgen-resistant CaP cell lines, DHT increased cytotoxicity of macrophages in a concentration-dependent manner. Further studies revealed that DHT induced M1 polarization and i...
Source: Endocrinology - June 10, 2019 Category: Endocrinology Authors: Lee GT, Kim JH, Kwon SJ, Stein MN, Hong JH, Nagaya N, Billakanti S, Kim MM, Kim WJ, Kim IY Tags: Endocrinology Source Type: research

Endocytosis and degradation of pegvisomant and a potential new mechanism that inhibits the nuclear translocation of GHR.
Conclusion: Our study showed that pegvisomant is a "moonlighting" antagonist. In addition, we revealed the mechanisms of the endocytosis, post-endocytic sorting, and degradation of pegvisomant. PMID: 30602026 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2018 Category: Endocrinology Authors: Hainan L, Li W, Li R, Zheng X, Luo G Tags: J Clin Endocrinol Metab Source Type: research

Alpha7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of Enteroendocrine L Cells In Vitro.
Abstract Enteroendocrine L cells secrete the incretin hormone glucagon-like peptide-1 (GLP-1) and they also express the α7 nicotinic acetylcholine receptor (α7nAChR) that might regulate GLP-1 secretion. Here, GTS-21, a selective α7nAChR agonist, was used to examine the impact of α7nAChR activation in L-cell lines, mouse intestinal primary cell cultures, and C57BL/6 mice. GTS-21 stimulated GLP-1 secretion in vitro and this effect was attenuated by an α7nAChR antagonist or by α7nAChR-specific siRNA. Under in vitro cell culture conditions of glucotoxicity, GTS-21 restored GLP-1 secretion and improved L-cell via...
Source: Endocrinology - July 9, 2018 Category: Endocrinology Authors: Wang D, Meng Q, Leech CA, Yepuri N, Zhang L, Holz GG, Wang C, Cooney RN Tags: Endocrinology Source Type: research

Reduced expression of mismatch repair genes MSH6/MSH2 directly promotes pituitary tumor growth via the ATR-Chk1 pathway.
Conclusion: Reduction of MSH6 and MSH2 expression at the mRNA and protein levels could be involved in direct PA proliferation by promoting cell-cycle progression or decreasing the rate of apoptosis through interference with the function of the ATR-Chk1 pathway. PMID: 29342268 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2018 Category: Endocrinology Authors: Uraki S, Ariyasu H, Doi A, Kawai S, Takeshima K, Morita S, Fukai J, Fujita K, Furuta H, Nishi M, Sugano K, Inoshita N, Nakao N, Yamada S, Akamizu T Tags: J Clin Endocrinol Metab Source Type: research

Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library.
This study is the first comprehensive analysis in discovering potential endocrine disrupters which affect the ERRα signaling pathway. PMID: 29216352 [PubMed - as supplied by publisher]
Source: Endocrinology - December 4, 2017 Category: Endocrinology Authors: Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M Tags: Endocrinology Source Type: research

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.
Conclusions: Reduced SLC19A1 expression in human adipocytes induces DNA hypermethylation resulting in increased expression of specific pro-inflammatory genes including CCL2. This constitutes an epigenetic mechanism that may link dysfunctional adipocytes to WAT inflammation and IR. PMID: 29121255 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 7, 2017 Category: Endocrinology Authors: Petrus P, Bialesova L, Checa A, Kerr A, Naz S, Bäckdahl J, Gracia A, Toft S, Dahlman-Wright K, Hedén P, Dahlman I, Wheelock CE, Arner P, Mejhert N, Gao H, Rydén M Tags: J Clin Endocrinol Metab Source Type: research

The role of NRG1 in the predisposition to papillary thyroid carcinoma.
Conclusions: Our data suggest a role for transcriptional regulation of NRG1 in the predisposition to PTC. PMID: 29121253 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - November 7, 2017 Category: Endocrinology Authors: He H, Li W, Liyanarachchi S, Wang Y, Yu L, Genutis LK, Maharry S, Phay JE, Shen R, Brock P, de la Chapelle A Tags: J Clin Endocrinol Metab Source Type: research

RAMP2 influences glucagon receptor pharmacology via trafficking and signaling.
Abstract Endogenous satiety hormones provide an attractive target for obesity drugs. Glucagon causes weight loss by reducing food intake and increasing energy expenditure. To further understand the cellular mechanisms by which glucagon and related ligands activate the glucagon receptor (GCGR), we have investigated the interaction of the GCGR with RAMP2, a member of the family of Receptor Activity Modifying Proteins.We have used a combination of competition binding experiments, cell surface ELISA, functional assays assessing the Gαs and Gq pathways and β-arrestin recruitment, and siRNA knockdown to examine the ef...
Source: Endocrinology - June 6, 2017 Category: Endocrinology Authors: Cegla J, Jones BJ, Gardiner JV, Hodson DJ, Marjot T, McGlone ER, Tan TM, Bloom SR Tags: Endocrinology Source Type: research

The adequate corpus luteum: miR-96 promotes luteal cell survival and progesterone production.
Conclusions: miR-96 targets FOXO1 to regulate luteal development through effects on cell survival and steroid production. The miR-183-96-182 cluster could provide a novel target for the manipulation of luteal function. PMID: 28368475 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 20, 2017 Category: Endocrinology Authors: Mohammed BT, Sontakke SD, Ioannidis J, Duncan WC, Donadeu FX Tags: J Clin Endocrinol Metab Source Type: research

Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue.
Abstract Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit triglyceride lipolysis in hepatocytes. We confirm the partial localization of HILPDA to lipid droplets and show that HILPDA is highly abundant in adipose tissue, where its expression is controlled by the peroxisome proliferator-activated receptor γ and by β-adrenergic stimulation. Levels of HILPDA mar...
Source: Endocrinology - March 17, 2017 Category: Endocrinology Authors: Dijk W, Mattijssen F, de la Rosa Rodriguez M, Loza Valdes A, Loft A, Mandrup S, Kalkhoven E, Qi L, Borst JW, Kersten S Tags: Endocrinology Source Type: research

Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin.
Conclusion: Activin A, B and AB produce comparable increases in human trophoblast cell invasion by up-regulating N-cadherin expression in a SMAD2/3-SMAD4-dependent manner. PMID: 25105734 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 8, 2014 Category: Endocrinology Authors: Li Y, Klausen C, Cheng JC, Zhu H, Leung PC Tags: J Clin Endocrinol Metab Source Type: research

PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN.
Conclusions: The current findings identify PI3K/AKT pathway as critical to the induction by TSH of IL-1RA in fibrocytes and GD-OF. Further PTEN modulates the amplitude of the induction. In GD-OF, relatively high basal PTEN levels prevent sIL-1RA expression or release of IL-1RA. Knocking down PTEN allows GD-OF to exhibit a pattern of IL-1RA expression resembling fibrocytes. PMID: 24840811 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - May 19, 2014 Category: Endocrinology Authors: Li B, Smith TJ Tags: J Clin Endocrinol Metab Source Type: research

TGF-β1 induces COX-2 expression and PGE2 production in human granulosa cells through Smad signaling pathways.
Conclusion: TGF-β1 induced PGE2 production by inducing COX-2 expression through a Smad-dependent signaling pathway in human granulosa cells. PMID: 24712567 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - April 8, 2014 Category: Endocrinology Authors: Fang L, Chang HM, Cheng JC, Leung PC, Sun YP Tags: J Clin Endocrinol Metab Source Type: research