Reduced expression of mismatch repair genes MSH6/MSH2 directly promotes pituitary tumor growth via the ATR-Chk1 pathway.

Conclusion: Reduction of MSH6 and MSH2 expression at the mRNA and protein levels could be involved in direct PA proliferation by promoting cell-cycle progression or decreasing the rate of apoptosis through interference with the function of the ATR-Chk1 pathway.
PMID: 29342268 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - January 12, 2018 Category: Endocrinology Authors: Uraki S, Ariyasu H, Doi A, Kawai S, Takeshima K, Morita S, Fukai J, Fujita K, Furuta H, Nishi M, Sugano K, Inoshita N, Nakao N, Yamada S, Akamizu T Tags: J Clin Endocrinol Metab Source Type: research