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Specialty: Dermatology

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Total 964 results found since Jan 2013.

Knockdown of CPEB1 and CPEB4 Inhibits Scar Formation via Modulation of TAK1 and SMAD Signaling
CONCLUSION: CPEB1 siRNA or CPEB4 siRNA inhibit scar formation by modulating the TAK1 and SMAD signaling pathways. Our study highlights CPEB1 and CPEB4 as potential therapeutic targets for the treatment of scar formation.PMID:37550230 | PMC:PMC10407338 | DOI:10.5021/ad.22.210
Source: Annals of Dermatology - August 7, 2023 Category: Dermatology Authors: Hui Song Cui You Ra Lee Yu Mi Ro So Young Joo Yoon Soo Cho June-Bum Kim Dong Hyun Kim Cheong Hoon Seo Source Type: research

741 The effect of skin ageing-related basement membrane collagen loss on the nucleus
Skin ageing effects, such as inflammation and disease are universal issues. Basement membrane collagens(BMC) are reduced by ageing and the consequences are poorly understood. BMC sensing of mechanical stress, vital for skin homeostasis, elicits signaling sensed via cytoskeletal actin filaments to the LINC complex(composed of Nesprin and Sun proteins), nuclear lamina and lamina-associated chromatin. RNA-Seq data from collagen 7(Col7) or collagen 17(Col17) siRNA knockdown primary keratinocytes revealed an opposing enrichment of nuclear function genes.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: S.K. Summan, A. Mayes, D.A. Gunn, J. Gautrot, M. Caley, E. O'Toole Source Type: research

801 Novel nanoparticles mediate efficient siRNA/mRNA co-delivery to melanoma
Checkpoint immunotherapy has revolutionized treatment for patients with advanced or metastatic melanoma; however, many patients ’ tumors either fail to respond or develop secondary resistance. As a result, there is an urgent need for an off-the-shelf local treatment that can improve therapeutic outcomes by increasing immune activation and reducing immunosuppressive factors. We developed a library of novel lipophilic poly(b eta-amino ester) (PBAE)-based biodegradable nanoparticle (NP) formulations with different backbone, sidechain, and endcap monomers and various lipophilic/linear ratios to efficiently co-deliver mRNA an...
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: K.M. Luly, E.E. Rocher, J.J. Green, S.Y. Tzeng, J.C. Sunshine Source Type: research

1092 Topical delivery of siRNA therapeutics into the skin using STAR particles
Small interfering RNA (siRNA) therapeutics offer promising gene silencing of disease targets in various tissues. Unlike traditional small molecules, siRNAs can be chemically optimized to target a particular tissue or cell type. This scaffold can then be reprogrammed with different target sequences for treatment of a wide array of genetically defined diseases. Unfortunately, topical delivery of macromolecules such as siRNA molecules into the skin is physically impaired by the stratum corneum barrier.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: M. Zain Ul Abideen, Q. Tang, H. Fakih, K. Gross, R. Furgal, C. Blanchard, C. Bouix-peter, T. Portal, A. Khvorova, J.E. Harris, J. Alterman Source Type: research

1099 Rational development of JAK1-selective siRNA therapeutics for the treatment of autoimmune skin diseases
JAK inhibition has surged as a popular treatment strategy for many inflammatory and autoimmune skin diseases. Current available small molecule JAK inhibitors in the clinic show distinct efficacy and safety profiles, likely reflecting their selectivity for certain JAK subtypes (i.e., JAK1, JAK2, JAK3, and tyrosine kinase 2 —TYK2). Achieving absolute JAK subtype selectivity remains challenging. RNA therapeutics, such as mRNAs, small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs), and aptamers, are a new generation of drug modality expected to dramatically accelerate the development of human medicine.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: Q. Tang, H. Fakih, M. Zain Ul Abideen, K. Afshari, K. Gross, J. Alterman, A. Khvorova, J.E. Harris Source Type: research

1166 Kinome siRNA screening for the treatment of the XPC cancer-prone disease
Xeroderma Pigmentosium C is a rare autosomal recessive genodermatosis. Patients with this disorder carry a mutation in DNA damage recognition protein XPC belonging to the nucleotide excision repair (NER) pathway. This generates a phenotype characterized by extreme photosensitivity and accumulation of UV-induced DNA damage without a repair potential. XP-C and normal patient-derived cells were used to screen a library of siRNAs aimed at decreasing the expression of all human kinases, given their involvement in different DNA repair pathways.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: F. Kobaisi, E. Sulpice, A. Nasrallah, X. Gidrol, W. Rachidi Source Type: research

1249 Research of hiperfect-mediated RNA interference targeting hTERT on the biological behavior of the human malignant melanoma cell line A375
Objective: To Research of hiperfect-mediated RNA interference targeting human telomerase reverse transcriptase gene (hTERT) on the biological behavior of the human malignant melanoma cell line A375.Methods: Specific siRNAs with green fluorescent labeling on different concentrations were transfected into A375 cells by using transfection reagent (Hiperfect) at different volumes . The transfection efficiency of cells was determined by fluorescen microscop, and the concentration of siRNA and volume of Hipetfect were selected.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: J. Zhao, Z. Mosha, X. Kang Source Type: research

1343 Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia
This study aimed to evaluate the therapeutic potential of a cell penetrating, AR-targeting asiRNA (cp-asiAR), which was designed to silence the AR gene, for AGA treatment.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: I. Moon, E. Choi, M. Choi, H. Cho, C. Won Source Type: research

TMEM232 Promotes the Inflammatory Response in Atopic Dermatitis via NF- κB and STAT3 Signaling Pathways
CONCLUSION: The study first outlines the function of TMEM232. It is involved in regulating inflammation in AD and may be a potential target for AD treatment.PMID:36928730 | DOI:10.1093/bjd/ljad078
Source: The British Journal of Dermatology - March 17, 2023 Category: Dermatology Authors: Jie Han Xinying Cai Shichun Qin Zengyunou Zhang Yuanyuan Wu Yuanzhe Shi Tingyue Deng Benjin Chen Li Liu Haisheng Qian Wenliang Fang Fengli Xiao Source Type: research

Inhibition of serum and glucocorticoid-regulated protein kinase-1 aggravates imiquimod-induced psoriatic dermatitis and enhances proinflammatory cytokine expression via the NF-kappaB pathway
In this study, we found that SGK1 expression was decreased in macrophages from psoriasis patients. Moreover, a specific pharmacological SGK1 inhibitor, EMD638683, significantly enhanced imiquimod (IMQ)-mediated TLR7/8 activity and proinflammatory cytokine production in RAW264.7 cells, and this result was confirmed by SGK1 siRNA.
Source: Journal of Investigative Dermatology - January 5, 2023 Category: Dermatology Authors: Qinqin Meng, Mei Bai, Meiliang Guo, Zhengxiao Li, Wanwen Liu, Xiaojing Fan, Rui Sun, Xinrong Yang, Dingfen Yuan, Yuling Shi, Hui Deng Tags: Original Article Source Type: research

183 Reduced FLG expression in atopic eczema reduces expression of key barrier genes and increases BMP signalling
Filaggrin (FLG) is a key cornified envelope and epidermal barrier protein. FLG mutations are the most strongly implicated genetic risk factor for atopic eczema (AE). FLG is part of a gene complex, called the epidermal differentiation complex (EDC), the genes of which contribute to various aspects of epidermal barrier function. FLG siRNA knockdown in keratinocytes caused a global reduction in EDC and Keratin (KRT) gene expression concomitant with up-regulation of bone morphogenetic protein (BMP) signalling.
Source: Journal of Investigative Dermatology - November 18, 2022 Category: Dermatology Authors: A.J. Hughes, B. Thomas, E.A. O ’Toole, R. O’Shaughnessy Source Type: research