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Specialty: Dermatology
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Total 964 results found since Jan 2013.
105 Regulation of keratinocyte differentiation through aryl hydrocarbon receptor signaling involves the transient activation of TFAP2A
Terminal differentiation of keratinocytes is essential for skin barrier development and tightly coordinated by a complex network of interacting transcription factors. Previous work identified the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor and environmental sensor, to orchestrate epidermal differentiation through transient activation of putative downstream transcription factors, amongst others TFAP2A. For proof-of-concept studies on a presumed AHR- TFAP2A axis that is co-opted in epidermal differentiation, we utilized siRNA-mediated TFAP2A knockdown in primary keratinocytes and CRISPR-Cas9 indu...
Source: Journal of Investigative Dermatology - October 1, 2021 Category: Dermatology Authors: F. Pardow, J.P. Smits, J. Qu, D. Rodijk-Olthuis, I.M. van Vlijmen-Willems, S.J. van Heeringen, H. Zhou, E.H. van den Bogaard Source Type: research
Interaction of galectin-7 with HMGCS1 in vitro may facilitate cholesterol deposition in cultured keratinocytes
Three-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase 1 (HMGCS1) was identified to interact with Gal-7, a pro-apoptotic β-galactoside binding protein, by yeast two-hybrid system. Their interaction was confirmed by in vitro β-galactosidase, BIA core and immunoprecipitation assays. Distinct interactive site of HMGCS1was found to reside at Phe-26. The expression of HMGCS1 in cultured keratinocytes was up-regulated by exogenous Gal-7 and down-regulated in Gal-7 siRNA transfected cells. HMGCS1-overexpressing cells were found to induce Gal-7 expression, which suggests that Gal-7 and HMGCS1 expressions are both stimulate...
Source: Journal of Investigative Dermatology - August 26, 2021 Category: Dermatology Authors: Norihiro Fujimoto, Minoru Akiyama, Yasushi Satoh, Shingo Tajima Tags: Original Article Source Type: research
Correction to: Thick melanoma in Tuscany
G Ital Dermatol Venereol. 2020 Dec;155(6):807. doi: 10.23736/S0392-0488.21.06995-9.ABSTRACTThis corrects the article DOI: 10.23736/S0392-0488.17.05584-5.PMID:33645939 | DOI:10.23736/S0392-0488.21.06995-9
Source: Giornale Italiano di Dermatologia e Venereologia - March 1, 2021 Category: Dermatology Authors: Alessandra Chiarugi Paolo Nardini Lorenzo Borgognoni Paola Brandani Gianni Gerlini Pietro Rubegni Arianna Lamberti Camilla Salvini Giovanni Lo Scocco Roberto Cecchi Riccardo Sirna Stefano Lorenzi Riccardo Gattai Silvio Battistini Emanuele Crocetti Source Type: research
