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Specialty: Dermatology
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Total 964 results found since Jan 2013.
The Role of Collagen VI α6 Chain Gene in Atopic Dermatitis
CONCLUSION: The reduction of epidermal COL6A6 due to the genetic mutation can cause skin barrier damage and it can contributes to the early onset of AD. COL6A6 is induced by IL-4 and IL-13, and it may play a role in fibrotic remodeling and inflammatory processes, which are major features of AD.PMID:35221595 | PMC:PMC8831303 | DOI:10.5021/ad.2022.34.1.46
Source: Annals of Dermatology - February 28, 2022 Category: Dermatology Authors: Hye Jung Jung Won Il Heo Kui Young Park Mi-Kyung Lee Ji Young Ahn Mi Youn Park Seong Jun Seo Source Type: research
NF- кB c-Rel modulates pre-fibrotic changes in human fibroblasts
AbstractSkin fibrosis is one central hallmark of the heterogeneous autoimmune disease systemic sclerosis. So far, there are hardly any standardized and effective treatment options. Pathogenic mechanisms underlying fibrosis comprise excessive and uncontrolled myofibroblast differentiation, increased extracellular matrix protein (ECM) synthesis and an intensification of the forces exerted by the cytoskeleton. A deeper understanding of fibroblast transformation could help to prevent or reverse fibrosis by specifically interfering with abnormally regulated signaling pathways. The transcription factor NF- κB has been implicate...
Source: Archives of Dermatological Research - December 9, 2021 Category: Dermatology Source Type: research
Discovering the role of FZD4 Gene in human cutaneous squamous cell carcinoma
Conclusion: The results indicated that FZD4 may play as a tumor suppressor gene in the pathogenesis of CSCC.
Source: Indian Journal of Dermatology - December 9, 2021 Category: Dermatology Authors: Ke Zhang Qun Lv Liming Li Mingjun Jiang Fang Fang Source Type: research
NF- кB c-Rel modulates pre-fibrotic changes in human fibroblasts
AbstractSkin fibrosis is one central hallmark of the heterogeneous autoimmune disease systemic sclerosis. So far, there are hardly any standardized and effective treatment options. Pathogenic mechanisms underlying fibrosis comprise excessive and uncontrolled myofibroblast differentiation, increased extracellular matrix protein (ECM) synthesis and an intensification of the forces exerted by the cytoskeleton. A deeper understanding of fibroblast transformation could help to prevent or reverse fibrosis by specifically interfering with abnormally regulated signaling pathways. The transcription factor NF- κB has been implicate...
Source: Archives of Dermatological Research - December 9, 2021 Category: Dermatology Source Type: research
132 Increased BMP Signalling Correlates with Increased Eczema Severity
Filaggrin (FLG) is a key cornified envelope and epidermal barrier protein. FLG mutations are the most strongly implicated genetic risk factor for atopic eczema (AE). FLG is part of a gene complex, called the epidermal differentiation complex (EDC), the genes of which contribute to various aspects of epidermal barrier function. A number of EDC and Keratin genes were downregulated and components of the bone morphogenetic protein (BMP) signalling pathway upregulated in RNA-seq from FLG siRNA knockdown keratinocytes.
Source: Journal of Investigative Dermatology - October 1, 2021 Category: Dermatology Authors: A.J. Hughes, B. Thomas, E.A. O ’Toole, R. O’Shaughnessy Source Type: research
