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Condition: Osteoarthritis
Procedure: Gastroschisis Repair
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Total 26 results found since Jan 2013.
Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF ‑κB and MAPK signalling transduction through integrin αVβ3
Int J Mol Med. 2023 Oct;52(4):97. doi: 10.3892/ijmm.2023.5300. Epub 2023 Sep 1.ABSTRACTOsteoarthritis (OA) is a chronic progressive articular illness which commonly affects older‑aged adults, presenting with cartilage inflammation and degradation. Rutaecarpine (RUT) has been shown to exert promising anti‑inflammatory effects; however, the efficacy of RUT in the treatment of OA is debatable. The present study investigated the potential of RUT in alleviating OA in a mouse model. Treatment with RUT inhibited the inflammatory response and extracellular matrix degradation by suppressing process regulators in interleukin (...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Junlai Wan Mengwei Li Xi Yuan Xiaojun Yu Anmin Chen Ming Shao Hao Kang Peng Cheng Source Type: research
The regulatory role and mechanism of lncTUG1 on cartilage apoptosis and inflammation in osteoarthritis
CONCLUSIONS: In conclusion, our study clarifies the role of the ceRNA regulatory network of TUG1/miR-144-3p/DUSP1/P38 MAPK in OA cartilage injury and provides an experimental and theoretical basis for genetic engineering tools to promote articular cartilage repair.PMID:37340458 | DOI:10.1186/s13075-023-03087-7
Source: Cell Research - June 20, 2023 Category: Cytology Authors: Nan-Nan Liu Yan-Ping Huang Yu-Bao Shao Xue-Fei Fan He-Yan Sun Tao-Rong Wang Tao Yao Xiao-Yu Chen Source Type: research
IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway
Cell Signal. 2023 Jan 18:110605. doi: 10.1016/j.cellsig.2023.110605. Online ahead of print.ABSTRACTGap junction intercellular communication (GJIC) allows the transfer of material, message and energy between cells, which influences cell behaviors including cell proliferation, migration, differentiation and apoptosis and determines cell fate. Interleukin-10 (IL-10), a versatile cytokine, attracts more and more attention in the cartilage pathology such as osteoarthritis (OA) due to its potential in anti-inflammatory and wound repair. However, whether IL-10 can mediate GJIC in chondrocytes remains elusive. In the current study...
Source: Cellular Signalling - January 21, 2023 Category: Cytology Authors: Daimo Guo Shiyi Kan Li Zhang Zhixing Niu Mengmeng Duan Yang Liu Xiaohua Pu Mingru Bai Caixia Pi Demao Zhang Chenchen Zhou Jing Xie Source Type: research
Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes
In conclusion, CH-CS nanoparticles can be considered as a candidate for gene therapy purposes in cartilage diseases.PMID:36049252 | DOI:10.1016/j.colsurfb.2022.112786
Source: Colloids and Surfaces - September 1, 2022 Category: Biotechnology Authors: Naghmeh Akbari Moghadam Fatemeh Bagheri Mohamadreza Baghaban Eslaminejad Source Type: research
Pin1-mediated regulation of articular cartilage stem/progenitor cell aging
In this study, we investigated the role of Pin1 in the aging of rat knee joint CSPCs. We isolated CSPCs from rat knee joints and demonstrated that, in long-term in vitro culture, Pin1 protein levels are significantly reduced. At the same time, expression of the senescence-related β-galactosidase and the senescence marker p16INK4A were markedly elevated. In addition, Pin1 overexpression reversed the progression of cellular senescence, as evidenced by the down-regulation of senescence-related β-galactosidase, increased EdU positive cells and diminished levels of p16INK4A. In contrast, Pin1 siRNA incorporation promoted CSPC...
Source: Tissue and Cell - March 1, 2022 Category: Cytology Authors: Xiao Zhang Weiwei Sun Weijie Wu Minhao Chen Tianyi Ji Hua Xu Youhua Wang Source Type: research
