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Infectious Disease: Influenza
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Total 113 results found since Jan 2013.
siRNAs pools generated in Escherichia coli exhibit strong RNA-interference activity against influenza virus genomic sequences
Virology. 2022 Dec 31;579:38-45. doi: 10.1016/j.virol.2022.12.013. Online ahead of print.ABSTRACTDue to the recurrent pandemic outbreaks that occurred during the last century, Influenza A viruses are considered a serious potential danger to human health. Among the innate immune pathways in eukaryotes, RNA interference plays a significant role in the interaction between viruses and host cells. RNA interference is addressed by small dsRNA molecules produced by the host itself (miRNAs, i.e. "micro-RNAs") but can be triggered also by the administration of exogenous short RNAs (siRNAs, "short interfering RNAs"). In this work, a...
Source: Virology - January 4, 2023 Category: Virology Authors: Riccardo Villa Sabrina Renzi Silvia Dotti Franco Lucchini Source Type: research
eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, and innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection and double-stranded RNA viral mimic stimulation induce the hypusination of eIF5A. Furthermore, we show that activation of eIF5A is essential for the replication of several RNA viruses including influenza A virus, vesicular stomatitis virus, chikungunya virus, mayaro virus, una virus, zika virus, and punta toro virus. Finally, our data reveal that inhibition of eIF5A hypusination...
Source: Frontiers in cellular and infection microbiology - July 27, 2022 Category: Microbiology Source Type: research
Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases
Curr Res Chem Biol. 2022;2:100021. doi: 10.1016/j.crchbi.2022.100021. Epub 2022 Feb 1.ABSTRACTViral diseases are prominent among the widely spread infections threatening human well-being. Real-life clinical successes of the few available therapeutics are challenged by pathogenic resistance and suboptimal delivery to target sites. Nanotechnology has aided the design of functionalised and non-functionalised Au and Ag nanobiomaterials through physical, chemical and biological (green synthesis) methods with improved antiviral efficacy and delivery. In this review, innovative designs as well as interesting antiviral activities ...
Source: Herpes - July 11, 2022 Category: Infectious Diseases Authors: Yusuf Oloruntoyin Ayipo Ajibola Abdulahi Bakare Umar Muhammad Badeggi Akeem Adebayo Jimoh Amudat Lawal Mohd Nizam Mordi Source Type: research
Knockdown of FLT4, Nup98, and Nup205 cellular genes effectively suppresses the reproduction of influenza virus strain A/WSN/1933 (H1N1) in vitro
CONCLUSION: We identified a number of genes such as FLT4, Nup98, and Nup205, the decrease in the expression of which can effectively suppress viral reproduction. The original siRNA sequences were also obtained. These results are important for the creation of therapeutic and prophylactic agents, whose action is based on the RNA interference mechanism.PMID:35339191 | DOI:10.2174/1871526522666220325121403
Source: Infectious Disorders Drug Targets - March 27, 2022 Category: Infectious Diseases Authors: Evgeny Pashkov Ekaterina Korchevaya Evgeny Faizuloev Artem Rtishchev Bogdan Cherepovich Elizaveta Bystritskaya Alexander Sidorov Alexander Poddubikov Anatoly Bykov Yuliya Dronina Oxana Svitich Vitaliy Zverev Source Type: research
Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs
Humans can be infected by zoonotic avian, pandemic and seasonal influenza A viruses (IAVs), which differ by receptor specificity and conformational stability of their envelope glycoprotein hemagglutinin (HA). It was shown that receptor specificity of the HA determines the tropism of IAVs to human airway epithelial cells, the primary target of IAVs in humans. Less is known about potential effects of the HA properties on viral attachment, infection and activation of human immune cells. To address this question, we studied the infection of total human peripheral blood mononuclear cells (PBMCs) and subpopulations of human PBMC...
Source: Frontiers in Immunology - March 14, 2022 Category: Allergy & Immunology Source Type: research
The long non-coding RNA LNC_000397 negatively regulates PRRSV replication through induction of interferon-stimulated genes
CONCLUSIONS: LNC_000397 negatively regulated PRRSV replication by inducing interferon-stimulated genes (ISGs) expression. Our study is the first report unveiling the role of host lncRNA in regulating PRRSV replication, which might be beneficial for the development of novel antiviral therapeutics.PMID:35248059 | DOI:10.1186/s12985-022-01761-x
Source: Herpes - March 6, 2022 Category: Infectious Diseases Authors: Jing Zhang Lipeng Gan Pu Sun Jian Wang Dong Li Yimei Cao Yuanfang Fu Pinghua Li Xingwen Bai Kun Li Xueqing Ma Huifang Bao Yingli Chen Jie Zhang Zaixin Liu Zengjun Lu Source Type: research
Mitochondrial DNA stress activates MHC class I antigen presentation and CD8+ T-cell immunity: implications for pulmonary fibrosis
Mitochondrial dysfunction is a hallmark of IPF and promotes the development of fibrosis. Mitochondrial stress has been shown to activate innate immunity via mitochondrial (mt) DNA sensing. However, whether mitochondrial stress regulates adaptive immune responses is unknown. We here investigated the regulation of MHC I antigen presentation by mitochondrial stress using a chronic mitochondrial dysfunction and an acute mtDNA stress model.Mouse embryonic fibroblasts derived from the PolgA mutator mouse, which represents a system of disturbed mitochondrial function, demonstrated concerted upregulation of the MHC I antigen prese...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Wang, X., Meul, T., Kammerl, I., Wang, Y., Mayr, C., Schiller, H. B., Meiners, S. Tags: Airway cell biology and immunopathology Source Type: research
Human sorting nexin 2 protein interacts with Influenza A virus PA protein and has a negative regulatory effect on the virus replication
CONCLUSIONS: This study revealed that the SNX2 and PA protein interact with each other in both yeast and HEK293 cells, and the SNX2 has a negative regulatory function on the virus replication. However, more knowledge is required to elucidate the action mechanism of the SNX2 on the influenza A virus replication at the molecular level.PMID:34817777 | PMC:PMC8611637 | DOI:10.1007/s11033-021-06906-9
Source: Molecular Biology Reports - November 24, 2021 Category: Molecular Biology Authors: Tu ğba Koçmar Elif Çağlayan Erkan Rayaman Kyosuke Nagata Kadir Turan Source Type: research
