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Targeted delivery of nucleic acids into xenograft tumors mediated by novel folate-equipped liposomes.
Abstract Folate receptors (FR) are cellular markers highly expressed in various cancer cells. Here, we report on the synthesis of a novel folate-containing lipoconjugate (FC) built of 1,2-di-O-ditetradecyl-rac-glycerol and folic acid connected via a PEG spacer, and the evaluation of the FC as a targeting component of liposomal formulations for nucleic acid (NA) delivery into FR expressing tumor cells. FR-targeting liposomes, based on polycationic lipid 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride (2X3), lipid helper dioleoylphosphatidylethanolamine (DOPE) and novel ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 18, 2017 Category: Drugs & Pharmacology Authors: Kabilova TO, Shmendel EV, Gladkikh DV, Chernolovskaya EL, Markov OV, Morozova NG, Maslov MA, Zenkova MA Tags: Eur J Pharm Biopharm Source Type: research

Targeting Phospholipase D4 Attenuates Kidney Fibrosis
Phospholipase D4 (PLD4), a single-pass transmembrane glycoprotein, is among the most highly upregulated genes in murine kidneys subjected to chronic progressive fibrosis, but the function of PLD4 in this process is unknown. Here, we found PLD4 to be overexpressed in the proximal and distal tubular epithelial cells of murine and human kidneys after fibrosis. Genetic silencing of PLD4, either globally or conditionally in proximal tubular epithelial cells, protected mice from the development of fibrosis. Mechanistically, global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the upregulation of ...
Source: Journal of the American Society of Nephrology : JASN - November 30, 2017 Category: Urology & Nephrology Authors: Trivedi, P., Kumar, R. K., Iyer, A., Boswell, S., Gerarduzzi, C., Dadhania, V. P., Herbert, Z., Joshi, N., Luyendyk, J. P., Humphreys, B. D., Vaidya, V. S. Tags: Basic Research Source Type: research

Caged siRNAs with single folic acid modification of antisense RNA for photomodulation exogenous and endogenous gene expression in cells
Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01952E, PaperLijia Yu, Nannan Jing, Zhenjun Yang, Li-He Zhang, XinJing Tang Manually controlling siRNA activity is an essentially important way to spatiotemporally investigate gene evaluation and functions. Due to the easy operation and precise manipulation, light could be used to regulate... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 7, 2018 Category: Molecular Biology Authors: Lijia Yu Source Type: research

Caged siRNAs with single folic acid modification of antisense RNA for photomodulation of exogenous and endogenous gene expression in cells
Org. Biomol. Chem., 2018, Advance Article DOI: 10.1039/C8OB01952E, PaperLijia Yu, Nannan Jing, Zhenjun Yang, Lihe Zhang, Xinjing Tang Photoregulating gene expression using folic acid modified caged siRNA through complex formation of folic acid/folate receptor. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 20, 2018 Category: Molecular Biology Authors: Lijia Yu Source Type: research

NF κB and Kidney Injury
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Yinxue Song, Bin Zhou, Xiangyang Du, Yong Wang, Jie Zhang, Yanqiu Ai, Zongjiang Xia, Gaofeng Zhao
Source: Biomedicine and Pharmacotherapy - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPAR α.
CONCLUSION: Folic acid improves hepatic lipid metabolism by upregulating PPARα levels via a SIRT1-dependent mechanism and restores hepatic one-carbon metabolism and diversity of gut microbiota, thereby attenuating HFD-induced NASH in rats. PMID: 32476787 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 13, 2020 Category: Gastroenterology Authors: Xin FZ, Zhao ZH, Zhang RN, Pan Q, Gong ZZ, Sun C, Fan JG Tags: World J Gastroenterol Source Type: research

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