NF κB and Kidney Injury

Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co-inhibitor of the JNK-activating kinase MKK7, and the NFκB-regulated antiapoptotic factor GADD45β could be of clinical value through GADD45B expression in multiple myeloma, which was confirmed to be effective in a subsequent clinical trial (146). However, considering the complexity of the NFκB pathways and the crosstalk between the pathways, there are numerous NFκB-independent side effects that are unrelated to the on-target effects of the inhibitors (147). Therefore, a more specific regulation of NFκB in the targeted disease must be cell-specific. In addition, as the NFκB system has a broad impact on all kinds of tissues, modulation of NFκB in diseased cells without effecting normal cells must be guaranteed. Therefore, we also need to focus on an appropriate delivery system that will transfer small-molecular inhibitors or gen...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Surendra Gulla, Dakshayani Lomada, Vadali V.S.S. Srikanth, Muthukonda Venkatakrishnan Shankar, Kakarla Raghava Reddy, Sarvesh Soni, Madhava C. ReddyAbstractNanoparticles' based cancer therapeutics are greatly dependent on the development of science and engineering of nanoparticles. In this article, important strategies based on nanoparticles used for cancer treatment are discussed. The inspiration to write this article is not only to review the existing strategies based on nanoparticles but also to highlight the pertinent and possible solutions ther...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Hemraj ChhipaAbstractExcess use of chemical fertilizers and pesticides has shown negative impacts on soil health and environment. Chemical residues destroy the soil ecosystem by affecting the non-targeted organisms and decrease soil fertility simultaneously. To prevent such adversity in soil and environment, researchers have applied nanotechnology in agriculture. Nanotechnology is the rising technology of the current decade, which has shown promising results in controlling excess agri-inputs and maintaining environmental balance. The characteristics...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Aaron Elbourne, Vi Khanh Truong, Samuel Cheeseman, Piumie Rajapaksha, Sheeana Gangadoo, James Chapman, Russell J. CrawfordAbstractAntimicrobial resistance (AMR) has been identified as one of the greatest threats to human health (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). Unfortunately, the current rise in AMR has made biofilm-related infections a primary health-care concern, since these biofilms can no longer be effectively treated using conventional antibiotic metho...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
ConclusionNo significant difference was found in the clinical manifestations, mortality, and complication between children and adults but children tended to have lesser chance of using alternative antibiotics, methylprednisolone and inhaled NO. The chance of associated cytomegalovirus (CMV) disease was also significantly lower in children.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
We present a new method to calculate the gap from measured coil inductance by studying the mutual inductance between the sensing coil and the target plate. From our analysis, we found that with this method only one calibration curve is needed for measuring the gap between the sensing coil and a metallic target plate made of different materials. We demonstrated this method can provide large measurement range (500 µm - 5000 µm) for inductive sensor with decent accuracy. The method can be widely used to 2D planar inductive sensor which is for facilitating measuring gap and detecting metallic objects ...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Publication date: Available online 21 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lamia Abou El-Kassem, Usama W. Hawas, Sahar El-Souda, Eman F. Ahmed, Wail El-Khateeb, Walid FayadAbstractForty-eight endophytic fungal strains were isolated and purified from ten Egyptian medicinal plants and their culture broth extracts were explored for HCV protease inhibitory activity and cytotoxicity. The ethyl acetate extracts of Alternaria alternata PGL-3, Cochlibolus lunatus PML-17, Nigrospora sphaerica EPS-38, followed by Emerecilla nidulans RPL-21 showed the most potent inhibition of HCV NS3/4A protease with...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
PMID: 31109488 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109486 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract OBJECTIVE: To review visual and anatomic outcomes after cataract surgery with complications in a teaching institution. METHODS: Consecutive case series. A chart review was conducted of patients who underwent phacoemulsification with intraoperative or postoperative complications, performed by ophthalmology residents under direct supervision of experienced ophthalmology attending physicians. Best corrected visual acuity (BCVA), OCT parameters, and postoperative treatments were reviewed at 1, 3, 6, and 12 months postoperatively. RESULTS: One hundred thirty-three eyes were analyzed. Mean BCVA was 50...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract OBJECTIVE: To determine the use of home care services in those with and without visual impairment in Canada. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Participants came from the baseline examination of the Canadian Longitudinal Study on Aging Comprehensive Cohort. Inclusion criteria included age between 45 and 85 years, community dwelling, and living near one of the 11 data collection sites across 7 Canadian provinces. People were excluded if they were in an institution, were living on a First Nations reserve, were full-time members of the Canadian Armed Forces, did not speak...
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
More News: Actos | African Health | Allergy & Immunology | Autoimmune Disease | Biology | Bone Graft | Cancer | Cancer & Oncology | Cancer Therapy | Carcinoma | Cardiology | Cardiovascular | China Health | Chronic Kidney Disease | Clinical Trials | Colorectal Cancer | Computers | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Eating Disorders & Weight Management | Endocrinology | Epidemiology | Epithelial Cancer | Fatty Liver Disease (FLD) | Folic Acid | Gastroschisis Repair | Genetics | Germany Health | Glomerulonephritis | Grants | Heart | Heart Transplant | Hepatocellular Carcinoma | Insect Bites & Stings | Insulin | Kidney Transplant | Kidney Transplantation | Liver | Liver Cancer | Liver Disease | Liver Transplant | Lupus | Medical Ethics | Men | Metabolic Syndrome | Molecular Biology | Myeloma | Nanotechnology | Nephritis | Obesity | Pathology | Perfusion | Proteinuria | Recession | Renal Failure | Restasis | Science | Study | Transplants | Urology & Nephrology | Vitamin B9 | Zinc