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Total 89 results found since Jan 2013.
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
J Exp Clin Cancer Res. 2022 Jul 1;41(1):214. doi: 10.1186/s13046-022-02406-1.ABSTRACTBACKGROUND: One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The RNA molecules with more than 200 nucleotides in length are known as lncRNAs and these epigenetic factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional and epigenetic levels. LncRNAs play vital biological functions in cells and in pathological events, hence their expression u...
Source: Clinical Prostate Cancer - June 30, 2022 Category: Cancer & Oncology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Elena Okina Mohammad Hossein Gholami Kiavash Hushmandi Mehrdad Hashemi Azuma Kalu Ali Zarrabi Noushin Nabavi Navid Rabiee Esmaeel Sharifi Hassan Karimi-Maleh Milad Ashrafizadeh Alan Prem Kumar Yuzhuo Wang Source Type: research
A cationic amino acid polymer nanocarrier synthesized in supercritical CO < sub > 2 < /sub > for co-delivery of drug and gene to cervical cancer cells
Colloids Surf B Biointerfaces. 2022 May 18;216:112584. doi: 10.1016/j.colsurfb.2022.112584. Online ahead of print.ABSTRACTThe present study was undertaken to investigate the ability of a drug curcumin-loaded polymer to inhibit the growth of cervical cancer cells by enhancing the anti-cancer efficiency of curcumin. We synthesized poly(methacryloyl beta-alanine) (PMBA) as a nanocarrier by radical polymerization in supercritical CO2. The results showed that the curcumin encapsulated and folic acid (FA)-treated PMBA (Poly@Cur-FA) for 24 h activated the reactive oxygen species-mediated programmed cell death machinery in HeLa ce...
Source: Colloids and Surfaces - May 26, 2022 Category: Biotechnology Authors: K V Kavya Stella Vargheese Shruti Shukla Imran Khan Debasish Kumar Dey Vivek K Bajpai Kavitha Thangavelu Raju Vivek R T Rajendra Kumar Young-Kyu Han Yun Suk Huh Yuvaraj Haldorai Source Type: research
Molecules, Vol. 27, Pages 1346: Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
g-Han Lee
Acute &beta;-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical curcumin. Differentiated H9C2 rat cardiomyocytes treated with ISO were assayed for glucose uptake, lactate release, and mitochondrial reactive oxygen species (ROS) generation. Survival was assessed by sulforhodamine B assays. Cardiomyocytes showed significantly decreased glucose uptake and lactate release, as well as increased ce...
Source: Molecules - February 16, 2022 Category: Chemistry Authors: Jin Hee Lee Da Hae Kim MinA Kim Kyung-Ho Jung Kyung-Han Lee Tags: Article Source Type: research
Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase
Biochem Biophys Res Commun. 2021 Sep 22;578:157-162. doi: 10.1016/j.bbrc.2021.09.041. Online ahead of print.ABSTRACTDecitabine (DAC), a DNA methyltransferase (DNMT) inhibitor is a novel anti-cancer drug regulating epigenetic mechanisms. Similar to conventional anti-cancer drugs, drug resistance to DAC also has been reported, resulting in tumor recurrence. Our previous study using colorectal cancer HCT116 cells found the decrease in deoxycytidine kinase (dCK) (activation enzyme of DAC) and the increase in cytidine deaminase (inactivation enzyme of DAC) in acquired DAC-resistant HCT116 (HCT116/DAC) cells. The aim of our stud...
Source: Biochemical and Biophysical Research communications - September 27, 2021 Category: Biochemistry Authors: Mika Hosokawa Risako Seiki Seigo Iwakawa Ken-Ichi Ogawara Source Type: research
Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury
In this study, a hypoxia/reoxygenation (H/R)-induced renal tubular epithelial cell (TEC) injury model and an ischaemia/reperfusion (I/R)-induced mouse AKI model were treated with CUR with or without mitochondrial inhibitors (rotenone and FCCP) or siRNA targeting mitochondrial transcription factor A (TFAM). Changes in mitochondrial function, inflammation, the antioxidant system and related pathways were analysed. In vitro, CUR suppressed NFκB activation and cytokine production and induced NRF2/HO-1 signalling in TECs under H/R conditions. CUR treatment also reduced mitochondrial ROS (mtROS) and mitochondrial fragmentation ...
Source: J Cell Mol Med - September 17, 2021 Category: Molecular Biology Authors: Ling Li Shuyun Liu Yijie Zhou Meng Zhao Yizhuo Wang Chengshi Wang Peng Lou Rongshuang Huang Liang Ma Yanrong Lu Ping Fu Jingping Liu Source Type: research
Ferritin: A Multifunctional Nanoplatform for Biological Detection, Imaging Diagnosis, and Drug Delivery
We reported that human HFn could selectively deliver a large amount of cargo into tumors in vivo via transferrin receptor 1 (TfR1)-mediated tumor-cell-specific targeting followed by rapid internalization. By the use of the intrinsic tumor-targeting property and unique nanocage structure of human HFn, a broad variety of cargo-loaded HFn formulations have been developed for biological analysis, imaging diagnosis, and medicine development. In view of the intrinsic tumor-targeting property, unique nanocage structure, lack of immunogenicity, and definite in vivo behavior, human HFn holds promise to promote therapeutic drugs, di...
Source: Cell Research - August 20, 2021 Category: Cytology Authors: Ningning Song Jianlin Zhang Jiao Zhai Juanji Hong Chang Yuan Minmin Liang Source Type: research
Pref-1 induced lung fibroblast differentiation by hypoxia through integrin α5β1/ERK/AP-1 cascade
Eur J Pharmacol. 2021 Jul 28:174385. doi: 10.1016/j.ejphar.2021.174385. Online ahead of print.ABSTRACTChronic obstructive asthma is characterized by airway fibrosis. Hypoxia and connective tissue growth factor (CTGF) play important roles in airway fibrosis. Preadipocyte factor-1 (Pref-1) participates in adipocyte differentiation and liver fibrosis. Herein, we investigated the role of Pref-1 in airway fibrosis in chronic obstructive asthma. We found that Pref-1 was overexpressed in lung tissues from chronic obstructive asthma patients compared to normal subjects. Extracellular matrix proteins were inhibited by Pref-1 small ...
Source: European Journal of Pharmacology - July 31, 2021 Category: Drugs & Pharmacology Authors: Wun-Hao Cheng Kang-Yun Lee Ming-Chih Yu Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets
Eur J Pharmacol. 2021 Jul 13:174344. doi: 10.1016/j.ejphar.2021.174344. Online ahead of print.ABSTRACTConsidering the fact that cancer cells can switch among various molecular pathways and mechanisms to ensure their progression, chemotherapy is no longer effective enough in cancer therapy. As an anti-tumor agent, doxorubicin (DOX) is derived from Streptomyces peucetius and can induce cytotoxicity by binding to topoisomerase enzymes to suppress DNA replication, leading to apoptosis and cell cycle arrest. However, efficacy of DOX in suppressing cancer progression is restricted by development of drug resistance. Cancer cells ...
Source: European Journal of Pharmacology - July 16, 2021 Category: Drugs & Pharmacology Authors: Sepideh Mirzaei Asal Jalal Abadi Mohammad Hossein Gholami Farid Hashemi Amirhossein Zabolian Kiavash Hushmandi Ali Zarrabi Maliheh Entezari Amir Reza Aref Haroon Khan Milad Ashrafizadeh Saeed Samarghandian Source Type: research
Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
