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Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR
Glycyrrhetinic acid (GA) is one of the main components for the traditional medicine of licorice, which can synchronize and promote effects of other medicines in the traditional prescription. In this paper we found GA could promote IEC-6 cell proliferation, rescue the proliferative inhibition caused by DFMO, decrease the apoptotic rate, and reverse the delay in restitution after wounding caused by DMFO in IEC-6 cells via HuR. To be noted, GA failed to promote proliferation and to suppress apoptosis after silencing HuR by siRNA in IEC-6 cells. Furthermore, with the model of small intestinal organoids developed from intestina...
Source: Frontiers in Pharmacology - May 15, 2019 Category: Drugs & Pharmacology Source Type: research

Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR ‐181b/SIRT1/HO‐1 signaling
This study aimed to investigate the role and underlying mechanism of LA in the abdominal aortic aneurysm (AAA). AAA model was established by continuous infusion of 1000 ng/kg/min of angiotensin II (AngII) in ApoE‐/‐ mice for 4 weeks. At 7 days before AngII administration, 5  mg/kg/day or 10 mg/kg/day of LA was intraperitoneally administered to mice and continued for 4 weeks. The characteristics and quantification of AAAs were determined in situ. Real‐time PCR or western blot was used to measure mRNA or protein levels of matrix metalloproteinase 2 and matrix metal loproteinase 9; pro‐inflammatory cytokines tum...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Xuhui Hou, Songbai Yang, Yan Zheng Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Anti-Inflammatory Effects of Licochalcone A on IL-1 β-Stimulated Human Osteoarthritis Chondrocytes
In conclusion, our re sults suggested that Lico A showed anti-inflammatory effects in IL-1β-stimulated chondrocytes by activating Nrf2 signaling pathway.
Source: Inflammation - October 25, 2017 Category: Allergy & Immunology Source Type: research

Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats.
Abstract Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 4, 2017 Category: Drugs & Pharmacology Authors: Wang LY, Cheng KC, Li Y, Niu CS, Cheng JT, Niu HS Tags: Biomed Pharmacother Source Type: research

Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M.
Abstract Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti-inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30, or 100mg/kg) 1h before lipopolysaccharide (LPS)/d-galactosamine (D-GalN) administration. In other in vitro experiment, RAW264.7 macrophages were pretreated with GA before LPS exposure. The mortality, hepatic tissue histology, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed. Toll like receptor 4 (TLR4), interleukin-1 recepto...
Source: Toxicology and Applied Pharmacology - February 13, 2017 Category: Toxicology Authors: Yin X, Xia G, Zhang L, Jiang R, Kuang G, Wang B, Chen X, Wan J Tags: Toxicol Appl Pharmacol Source Type: research

Licorice Root Components in Dietary Supplements are Selective Estrogen Receptor Modulators with a Spectrum of Estrogenic and Anti-Estrogenic Activities
Publication date: Available online 26 November 2015 Source:Steroids Author(s): Nittaya Boonmuen, Ping Gong, Zulfiqar Ali, Amar G. Chittiboyina, Ikhlas Khan, Daniel R. Doerge, William G. Helferich, Kathryn E. Carlson, Teresa Martin, Pawinee Piyachaturawat, John A. Katzenellenbogen, Benita S. Katzenellenbogen Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extra...
Source: Steroids - November 27, 2015 Category: Drugs & Pharmacology Source Type: research