• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling
CONCLUSIONS: We demonstrated that GP73 promoted the ox-LDL-induced inflammation in macrophages by affecting the NF-κB/NLRP3 inflammasome signaling, and may play a role in atherosclerosis.PMID:37271284 | DOI:10.1016/j.ijcard.2023.05.059
Source: Atherosclerosis - June 4, 2023 Category: Cardiology Authors: Yi-Fen Lin Miao-Hong Li Ri-Hua Huang Shao-Zhao Zhang Xing-Feng Xu Hui-Min Zhou Meng-Hui Liu Xin-Xue Liao Li-Zhen Liao Yue Guo Xiao-Dong Zhuang Source Type: research

SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3)
CONCLUSIONS: We identified SIRT6 as a new regulator of the activity of NOS3, with functional implications for endothelial-dependent relaxation.PMID:36720357 | DOI:10.1016/j.bcp.2023.115439
Source: Biochemical Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Jiaojiao Wang Zhiping Liu Jing Lu Jiami Zou Weile Ye Hong Li Si Gao Peiqing Liu Source Type: research

Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production
Cell Signal. 2022 Jul 26:110419. doi: 10.1016/j.cellsig.2022.110419. Online ahead of print.ABSTRACTIntraplaque hemorrhage (IPH) accelerates atherosclerosis progression. To scavenge excessive red blood cells (RBCs), vascular smooth muscle cells (VSMCs) with great plasticity may function as phagocytes. Here, we investigated the erythrophagocytosis function of VSMCs and possible regulations involved. Based on transcriptional microarray analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that genes up-regulated in human carotid atheroma with IPH were enriched in functions of phagocytic activiti...
Source: Atherosclerosis - July 29, 2022 Category: Cardiology Authors: Daorong Pan Wen Wu Guangfeng Zuo Xiangrong Xie Hui Li Xiaomin Ren Chaohua Kong Wenying Zhou Zihan Zhang Martin Waterfall Shaoliang Chen Source Type: research

HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis
Biochem Pharmacol. 2021 Jul 30:114716. doi: 10.1016/j.bcp.2021.114716. Online ahead of print.ABSTRACTA total number of 18 different isoforms of histone deacetylases (HDACs) which were categorized into 4 classes have been identified in human. HDAC3 is categorized as Class I HDACs and is closely related to the occurrence and development of atherosclerosis. Recent evidence has pointed to endothelial-to-mesenchymal transition (EndMT) as a key process in vascular inflammation in atherosclerosis. However, little is known about the effect of HDAC3 on EndMT in atherosclerosis. Therefore, we aimed to investigate the effect of HDAC3...
Source: Biochemical Pharmacology - August 2, 2021 Category: Drugs & Pharmacology Authors: Lifang Chen Chenxu Shang Bo Wang Guan Wang Zhen Jin Feng Yao Zejun Yue Liang Bai Rong Wang Sihai Zhao Enqi Liu Weirong Wang Source Type: research

C-C Motif Ligand 8 promotes atherosclerosis via NADPH Oxidase 2/Reactive Oxygen Species-induced endothelial permeability Increase
This study might contribute to a deeper understanding of the connection between chemokines and atherosclerosis.PMID:33741452 | DOI:10.1016/j.freeradbiomed.2021.02.022
Source: Free Radical Biology and Medicine - March 20, 2021 Category: Biology Authors: Song Xue Hanfei Tang Gefei Zhao Chao Fang Yang Shen Dong Yan Ye Yuan Weiguo Fu Zhenyu Shi Xiao Tang Daqiao Guo Source Type: research

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
Discussion Dynamic changes in the functional phenotype of macrophages are associated with pathogenesis of inflammatory diseases (5–7). TonEBP primes macrophages toward an M1 phenotype, which has pro-inflammatory properties. TonEBP does this by promoting expression of pro-inflammatory genes via interaction with NF-κB (36) and by binding directly to the promoter (37, 64). In addition, TonEBP suppresses expression of the anti-inflammatory cytokine IL-10 by limiting chromatin access to the promoter (37). The pro-inflammatory function of TonEBP suggests that inhibiting its expression or activation could suppres...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2.
Conclusions -We revealed that a novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via S1PR2-G12/13-RhoA signaling. Downregulation of FAM19A5 during obesity may trigger cardiometabolic diseases. PMID: 29453251 [PubMed - as supplied by publisher]
Source: Circulation - February 16, 2018 Category: Cardiology Authors: Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, Kong W Tags: Circulation Source Type: research