• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Targeting HDAC11 activity by FT895 Restricts EV71 Replication
Virus Res. 2023 Apr 4:199108. doi: 10.1016/j.virusres.2023.199108. Online ahead of print.ABSTRACTEnterovirus 71 (EV71) infection mainly causes hand, foot, and mouth disease (HFMD) and remains a serious public health problem to the children under the age of 5. Until now, there is no specific drug to treat HFMD in clinical and there is an urgent to explore the new target and the new drug to address clinical challenges. At present, we found histone deacetylase 11 (HDAC11) involves in supporting EV71 replication. We also used HDAC11 siRNA and an HDAC11 inhibitor FT895 to downregulate HDAC11 expression and found that targeting ...
Source: Virus Research - April 6, 2023 Category: Virology Authors: Hong Xie Enhui Yang Chaoyong Wang Chunyan Peng Lianfu Ji Source Type: research

Enterovirus A71 2B Inhibits Interferon-Activated JAK/STAT Signaling by Inducing Caspase-3-Dependent Karyopherin- α1 Degradation
In this report, we showed that 2B, a non-structural protein of EV-A71, was critical to the suppression of the IFN-α-induced type I response in infected cells. Among viral proteins, 2B was the only one that was involved in the degradation of KPNA1, which impeded the formation of the p-STAT1/2/KPNA1 complex and blocked the translocation of p-STAT1/2 into the nucleus upon IFN-α stimulation. Degradation of KPNA1 induced by 2B can be inhibited in the cells pre-treated with Z-DEVD-FMK, a caspase-3 inhibitor, or siRNA targeting caspase-3, indicating that 2B-induced degradation of KPNA1 was caspase-3 dependent. The mechanism by ...
Source: Frontiers in Microbiology - December 21, 2021 Category: Microbiology Source Type: research

BNIP3 deletion ameliorated enterovirus 71 infection-induced hand, foot and mouth disease via inhibiting apoptosis, autophagy, and inflammation in mice.
Abstract Bcl2/adenovirus E1B protein-interacting protein 3 (BNIP3) plays a key role in cellular response to stress by regulating apoptosis and selective autophagy. The present study aimed to determine the effects of BNIP3 on enterovirus (EV) 71 infection-induced hand, foot and mouth disease (HFMD), and the apoptosis, autophagy and inflammatory in mice and SH-SY5Y human neuroblastoma cell line. Neonatal BALB/c mice were injected with EV 71 strain to induce the HFMD. Western blotting and ELISA were used to measure the protein expression and cytokine levels. The BNIP3 mRNA and protein levels in the brain were increas...
Source: International Immunopharmacology - July 23, 2020 Category: Allergy & Immunology Authors: Zhu L, Hao X, Cao J, Xie X, Wang H Tags: Int Immunopharmacol Source Type: research

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - December 30, 2018 Category: Infectious Diseases Source Type: research

Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71infections in vitro
In this study, siRNA interference technique and transgenic technique were used to investigate the interaction between HSP70 and EV71 virus. The result demonstrated that the cell surface HSP70 is not essential for EV71 infection but helps the initial binding of virus to host cells and that multiple receptors are involved during EV71 infection. In addition, HSP70 was upregulated in human neuroblastoma cells (SK-N-SH) infected with EV71.Graphical abstractEnterovirus 71 (EV71) is a causative agent of hand food and mouth disease (HFMD) in young children and it can cause the damage of nervous cells, cytokine storm and toxic subs...
Source: Microbial Pathogenesis - December 22, 2018 Category: Infectious Diseases Source Type: research

Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor.
Abstract Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease (HFMD) associated with severe neurological disease. EV71's pathogenesis remains poorly understood and the lack of approved antiviral has led to its emergence as a clinically important neurotropic virus. The goals of this study were to: (i) identify novel anti-EV71 compounds that may serve as lead molecules for therapeutics; and (ii) investigate their targets in downstream studies. We screened a 502-compound library of highly purified natural products for anti-EV71 activities in a cell-based immunofluorescence assay that w...
Source: Antiviral Research - April 17, 2017 Category: Virology Authors: Wu KX, Chu JJ Tags: Antiviral Res Source Type: research

Antiviral screen identifies EV71 inhibitors and reveals camptothecin-target, DNA topoisomerase 1 as a novel EV71 host factor
Publication date: Available online 17 April 2017 Source:Antiviral Research Author(s): Kan Xing Wu, Justin Jang-Hann Chu Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease (HFMD) associated with severe neurological disease. EV71's pathogenesis remains poorly understood and the lack of approved antiviral has led to its emergence as a clinically important neurotropic virus. The goals of this study were to: (i) identify novel anti-EV71 compounds that may serve as lead molecules for therapeutics; and (ii) investigate their targets in downstream studies. We screened a 502-compound library of hi...
Source: Antiviral Therapy - April 17, 2017 Category: Virology Source Type: research