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Infectious Disease: H1N1

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Total 17 results found since Jan 2013.

Bifunctional siRNA containing immunostimulatory motif 2 enhances protection against pandemic H1N1 virus infection.
CONCLUSIONS: This study paves the way for broad-spectrum RNAi-based therapeutics using immunostimulatory motif towards improved antiviral effect. Hence this approach will be useful to confront the sudden emergence of pandemic strains. PMID: 26264705 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - August 12, 2015 Category: Genetics & Stem Cells Authors: Joshi G, Dash PK, Agarwal A, Sharma S, Parida M Tags: Curr Gene Ther Source Type: research

Optimised design of siRNA based on multi-featured comparison and analysis of H1N1 virus.
In this study, we developed a computational method for designing therapeutics siRNA and applied in the recent HIN1 influenza virus based on its biological characteristics that are substantially different from seasonal influenza virus. We first compared the PA fragments between the H IN1 virus in 2009 and the seasonal influenza virus genes in 2008, and the comparison found significant differences between them not only in sequence features but also in RNA secondary structures. In particular, the RNA secondary structures only share 76.8% identity, which suggests major changes in biological characteristics. Furthermore, we des...
Source: International Journal of Data Mining and Bioinformatics - June 29, 2013 Category: Bioinformatics Authors: Liu Y, Chang Y, Xu D, Li Z, Zhang H, Li J, Tian M Tags: Int J Data Min Bioinform Source Type: research

Knockdown of FLT4, Nup98, and Nup205 cellular genes effectively suppresses the reproduction of influenza virus strain A/WSN/1933 (H1N1) in vitro
CONCLUSION: We identified a number of genes such as FLT4, Nup98, and Nup205, the decrease in the expression of which can effectively suppress viral reproduction. The original siRNA sequences were also obtained. These results are important for the creation of therapeutic and prophylactic agents, whose action is based on the RNA interference mechanism.PMID:35339191 | DOI:10.2174/1871526522666220325121403
Source: Infectious Disorders Drug Targets - March 27, 2022 Category: Infectious Diseases Authors: Evgeny Pashkov Ekaterina Korchevaya Evgeny Faizuloev Artem Rtishchev Bogdan Cherepovich Elizaveta Bystritskaya Alexander Sidorov Alexander Poddubikov Anatoly Bykov Yuliya Dronina Oxana Svitich Vitaliy Zverev Source Type: research

Inhibition of influenza A virus by mixed siRNAs, targeting the PA, NP, and NS genes, delivered by hybrid microcarriers
In conclusion, we have developed a proof-of-principle which shows that our hybrid microcarrier technology (utilizing a therapeutic siRNA cocktail) may represent a promising approach in anti-influenza therapy.Graphical abstract
Source: Antiviral Therapy - August 6, 2018 Category: Virology Source Type: research

Inhibition of influenza A virus by mixed siRNAs, targeting the PA, NP, and NS genes, delivered by hybrid microcarriers.
In conclusion, we have developed a proof-of-principle which shows that our hybrid microcarrier technology (utilizing a therapeutic siRNA cocktail) may represent a promising approach in anti-influenza therapy. PMID: 30092251 [PubMed - as supplied by publisher]
Source: Antiviral Research - August 6, 2018 Category: Virology Authors: Brodskaia AV, Timin AS, Gorshkov AN, Muslimov AR, Bondarenko AB, Tarakanchikova YV, Zabrodskaya YA, Baranovskaya IL, Il'inskaja EV, Sakhenberg EI, Sukhorukov GB, Vasin AV Tags: Antiviral Res Source Type: research

Molecules, Vol. 22, Pages 1754: Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways
In conclusion, emodin can inhibit IAV replication and influenza viral pneumonia, at least in part, by activating Nrf2 signaling and inhibiting IAV-induced activations of the TLR4, p38/JNK MAPK and NF-κB pathways.
Source: Molecules - October 18, 2017 Category: Chemistry Authors: Jian-Ping Dai Qian-Wen Wang Yun Su Li-Ming Gu Ying Zhao Xiao-Xua Chen Cheng Chen Wei-Zhong Li Ge-Fei Wang Kang-Sheng Li Tags: Article Source Type: research

Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza
During viral infection of human cells, host kinases mediate signaling activities that are used by all viruses for replication; therefore, targeting of host kinases is of broad therapeutic interest. Here, host kinases were globally screened during human influenza virus (H1N1) infection to determine the time-dependent effects of virus infection and replication on kinase function. Desthiobiotin-labeled analogs of adenosine triphosphate and adenosine diphosphate were used to probe and covalently label host kinases in infected cell lysates, and probe affinity was determined. Using infected human A549 cells, we screened for time...
Source: Journal of Biomolecular Screening - June 24, 2014 Category: Molecular Biology Authors: Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, K., Noah, J. W. Tags: Original Research Source Type: research

Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus
Molecular PharmaceuticsDOI: 10.1021/mp500745v
Source: Molecular Pharmaceutics - January 30, 2015 Category: Drugs & Pharmacology Authors: Wanling Liang, Michael Y. T. Chow, Pui Ngan Lau, Qi Tony Zhou, Philip C. L. Kwok, George P. H. Leung, A. James Mason, Hak-Kim Chan, Leo L. M. Poon and Jenny K. W. Lam Source Type: research

ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection.
Abstract Intercellular cell adhesion molecule-1 (ICAM-1) is an inducible cell surface glycoprotein that is expressed on many cell types. Influenza virus infection enhanced ICAM-1 expression and messenger RNA levels. Human bronchial epithelial cells (HBEpC) and nasal epithelial cells, on exposure to different strains of influenza virus (H1N1, H3N2, and H9N1) showed significant increase in ICAM-1 gene expression (p<0.001) along with the ICAM-1 protein levels (surface and secreted). Depleting ICAM-1 in HBEpC with ICAM-1 siRNA and subsequently infecting with H1N1 showed increased viral copy numbers. Influenza virus...
Source: Virology - October 22, 2015 Category: Virology Authors: Othumpangat S, Noti JD, McMillen CM, Beezhold DH Tags: Virology Source Type: research

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization.
Abstract The hemagglutinin (HA) protein of influenza A virus initiates cell entry by binding to sialic acids on target cells. In the current study, we demonstrated that in addition to sialic acids, influenza A/Puerto Rico/8/34 H1N1 (PR8) virus HA specifically binds to cell surface nucleolin (NCL). The interaction between HA and NCL was initially revealed with virus overlay protein binding assay (VOPBA) and subsequently verified with co-immunoprecipitation. Importantly, inhibiting cell surface NCL with NCL antibody, blocking PR8 viruses with purified NCL protein, or depleting endogenous NCL with siRNA all substanti...
Source: Virology - April 12, 2016 Category: Virology Authors: Chan CM, Chu H, Zhang AJ, Leung LH, Sze KH, Kao RY, Chik KK, To KK, Chan JF, Chen H, Jin DY, Liu L, Yuen KY Tags: Virology Source Type: research