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Infectious Disease: H1N1
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Total 17 results found since Jan 2013.
Identification and characterization of GLDC as host susceptibility gene to severe influenza
Glycine decarboxylase (GLDC) modulates host antiviral response upon viral infection due to the existence of GLDC ‐pyrimidine biosynthesis‐innate immunity axis. The inter‐individual differential GLDC expression derived from genetic variation may dictate the susceptibility to severe influenza. AbstractGlycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. The higher expression of GLDC derived from genetic variations may confer a higher risk to H7N9 and severe H1N1 infection. We sought to characterize GLDC as functional susceptibility gene that GLDC may intrinsical...
Source: EMBO Molecular Medicine - November 28, 2018 Category: Molecular Biology Authors: Jie Zhou,
Dong Wang,
Bosco Ho ‐Yin Wong,
Cun Li,
Vincent Kwok‐Man Poon,
Lei Wen,
Xiaoyu Zhao,
Man Chun Chiu,
Xiaojuan Liu,
Ziwei Ye,
Shuofeng Yuan,
Kong‐Hung Sze,
Jasper Fuk‐Woo Chan,
Hin Chu,
Kelvin Kai‐Wang To,
Kwok Yung Yuen Tags: Research Article Source Type: research
Antibodies against H1N1 influenza virus hemagglutinin cross-react with prohibitin.
Abstract
Influenza virus infection is associated with type 1 diabetes (T1DM), but its pathogenesis remains unclear. Here, our study found that one of the monoclonal antibodies against H1N1 influenza virus hemagglutinin(HA) cross-reacted with human pancreatic tissue and further demonstrated that it binded to rat islet β-cells. We immunoprecipitated islet protein with this cross-reactive antibody and identified the bound antigen as prohibitin by mass spectrometry. We then expressed the prohibitin protein in bacteria and confirmed the antibody binding to prohibitin by Western blot. We also verified the cross-reactiv...
Source: Biochemical and Biophysical Research communications - April 5, 2019 Category: Biochemistry Authors: Sun L, Li H, Sun J, Guo C, Feng Y, Li Y, Zhao X, Xie X, Hu J Tags: Biochem Biophys Res Commun Source Type: research
