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Source: World Journal of Gastroenterology : WJG
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Total 125 results found since Jan 2013.
Fish oil alleviates liver injury induced by intestinal ischemia/reperfusion via AMPK/SIRT-1/autophagy pathway.
CONCLUSION: Our study indicates that FO may protect the liver against intestinal I/R induced injury through the AMPK/SIRT-1/autophagy pathway.
PMID: 29467553 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 21, 2018 Category: Gastroenterology Authors: Jing HR, Luo FW, Liu XM, Tian XF, Zhou Y Tags: World J Gastroenterol Source Type: research
Hepatitis C virus core protein-induced miR-93-5p up-regulation inhibits interferon signaling pathway by targeting IFNAR1.
CONCLUSION: HCV-1b core protein-induced miR-93-5p up-regulation inhibits the IFN signaling pathway by directly targeting IFNAR1, and the miR-93-5p-IFNAR1 axis regulates STAT1 phosphorylation. This axis may be a potential therapeutic target for HCV-1b infection.
PMID: 29375208 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: He CL, Liu M, Tan ZX, Hu YJ, Zhang QY, Kuang XM, Kong WL, Mao Q Tags: World J Gastroenterol Source Type: research
β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice.
CONCLUSION: β-arrestin 2 can protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation.
PMID: 29375207 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2018 Category: Gastroenterology Authors: Jiang MP, Xu C, Guo YW, Luo QJ, Li L, Liu HL, Jiang J, Chen HX, Wei XQ Tags: World J Gastroenterol Source Type: research
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.
CONCLUSION: The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity.
PMID: 29358858 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 28, 2017 Category: Gastroenterology Authors: Sun W, Wu HY, Chen S Tags: World J Gastroenterol Source Type: research
miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1.
CONCLUSION: This study demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1.
PMID: 29290651 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Liu XL, Cao HX, Wang BC, Xin FZ, Zhang RN, Zhou D, Yang RX, Zhao ZH, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research
Palmitate induces fat accumulation by activating C/EBP β-mediated G0S2 expression in HepG2 cells.
CONCLUSION: Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPβ-mediated G0S2 expression.
PMID: 29209111 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 21, 2017 Category: Gastroenterology Authors: Zhao NQ, Li XY, Wang L, Feng ZL, Li XF, Wen YF, Han JX Tags: World J Gastroenterol Source Type: research
Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells.
CONCLUSION: Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1.
PMID: 28974890 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Lu CJ, He YF, Yuan WZ, Xiang LJ, Zhang J, Liang YR, Duan J, He YH, Li MY Tags: World J Gastroenterol Source Type: research
HOX transcript antisense intergenic RNA represses E-cadherin expression by binding to EZH2 in gastric cancer.
CONCLUSION: HOTAIR may play a pivotal role in tumor cell migration and invasion. It can be used as a potential diagnostic and prognostic biomarker for GC.
PMID: 28970725 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 7, 2017 Category: Gastroenterology Authors: Chen WM, Chen WD, Jiang XM, Jia XF, Wang HM, Zhang QJ, Shu YQ, Zhao HB Tags: World J Gastroenterol Source Type: research
Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.
CONCLUSION: AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy. These findings could have applications in cancer management.
PMID: 28596680 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 21, 2017 Category: Gastroenterology Authors: Abdel-Rahman WM, Al-Khayyal NA, Nair VA, Aravind SR, Saber-Ayad M Tags: World J Gastroenterol Source Type: research
Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.
CONCLUSION: These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis.
PMID: 28246472 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 13, 2017 Category: Gastroenterology Authors: Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP Tags: World J Gastroenterol Source Type: research
miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism.
CONCLUSION: The miR-133a-UCP2 pathway participates in IBD by altering downstream inflammation, oxidative stress and markers of energy metabolism, which provides novel clues and potential therapeutic targets for IBD.
PMID: 28104982 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 6, 2017 Category: Gastroenterology Authors: Jin X, Chen D, Zheng RH, Zhang H, Chen YP, Xiang Z Tags: World J Gastroenterol Source Type: research
Role of mast cell-miR-490-5p in irritable bowel syndrome.
CONCLUSION: miR-490-5p plays a vital role in the pathogenesis of irritable bowel syndrome by affecting mast cell proliferation and apoptosis; with down-regulation of miR-490-5p, the mRNA level of mast cell tryptase and PAR-2 increased, and the protein level increased, but the difference was not statistically significant.
PMID: 28104984 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 6, 2017 Category: Gastroenterology Authors: Ren HX, Zhang FC, Luo HS, Zhang G, Liang LX Tags: World J Gastroenterol Source Type: research
Vitamin D differentially regulates Salmonella-induced intestine epithelial autophagy and interleukin-1 β expression.
CONCLUSION: Active vitamin D might enhance autophagic clearance of Salmonella infection, while modulation of inflammatory responses prevents the host from detrimental effects of overwhelming inflammation.
PMID: 28058015 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 20, 2016 Category: Gastroenterology Authors: Huang FC Tags: World J Gastroenterol Source Type: research
Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression.
CONCLUSION: Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression and might act as an anti-cancer therapeutic target in the future.
PMID: 28018113 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 6, 2016 Category: Gastroenterology Authors: Su JR, Kuai JH, Li YQ Tags: World J Gastroenterol Source Type: research
IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro.
CONCLUSION: Treatment with IRF5 siRNA can reverse the pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in SAP associated with ALI.
PMID: 27895424 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 13, 2016 Category: Gastroenterology Authors: Sun K, He SB, Qu JG, Dang SC, Chen JX, Gong AH, Xie R, Zhang JX Tags: World J Gastroenterol Source Type: research
