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Source: World Journal of Gastroenterology : WJG

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Total 125 results found since Jan 2013.

Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-siRNA.
CONCLUSION: Knockdown of NF-κB/p65 with siRNA is an effective strategy for inhibiting HepG2 cell growth by downregulating P-gp expression associated chemosensitization and apoptosis induction. PMID: 26668505 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 7, 2015 Category: Gastroenterology Authors: Shi Y, Wang SY, Yao M, Sai WL, Wu W, Yang JL, Cai Y, Zheng WJ, Yao DF Tags: World J Gastroenterol Source Type: research

siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells.
CONCLUSION: Inhibition of GHR in human colon cancer SW480 cells resulted in anti-tumor effects in nude mice. PMID: 24307807 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 28, 2013 Category: Gastroenterology Authors: Zhou D, Yang J, Huang WD, Wang J, Zhang Q Tags: World J Gastroenterol Source Type: research

IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro.
CONCLUSION: Treatment with IRF5 siRNA can reverse the pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in SAP associated with ALI. PMID: 27895424 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 13, 2016 Category: Gastroenterology Authors: Sun K, He SB, Qu JG, Dang SC, Chen JX, Gong AH, Xie R, Zhang JX Tags: World J Gastroenterol Source Type: research

PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation.
CONCLUSION: PU.1-silenced semi-mature DCs induced partial immune tolerance both in vitro and in vivo, which could be used as a new strategy to promote transplantation tolerance. PMID: 24282365 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 21, 2013 Category: Gastroenterology Authors: Xu XW, Ding BW, Zhu CR, Ji W, Li JS Tags: World J Gastroenterol Source Type: research

Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells.
CONCLUSION: COX-2 likely functions upstream of NF-κB and regulates the expression of E-cadherin via NF-κB/Snail signaling pathway in gastric cancer cells. PMID: 24115825 [PubMed - as supplied by publisher]
Source: World Journal of Gastroenterology : WJG - October 7, 2013 Category: Gastroenterology Authors: Liu XJ, Chen ZF, Li HL, Hu ZN, Liu M, Tian AP, Zhao D, Wu J, Zhou YN, Qiao L Tags: World J Gastroenterol Source Type: research

Vitamin D differentially regulates Salmonella-induced intestine epithelial autophagy and interleukin-1 β expression.
CONCLUSION: Active vitamin D might enhance autophagic clearance of Salmonella infection, while modulation of inflammatory responses prevents the host from detrimental effects of overwhelming inflammation. PMID: 28058015 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 20, 2016 Category: Gastroenterology Authors: Huang FC Tags: World J Gastroenterol Source Type: research

Clinical significance of human kallikrein 12 gene expression in gastric cancer.
CONCLUSION: The KLK12 gene is markedly overexpressed in GC tissue, and its expression status may be a powerful prognostic indicator for patients with GC. KLK12 might serve as a novel diagnosis and prognosis biomarker in GC. PMID: 23236234 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 7, 2012 Category: Gastroenterology Authors: Zhao EH, Shen ZY, Liu H, Jin X, Cao H Tags: World J Gastroenterol Source Type: research

Clinicopathological and biological significance of cripto overexpression in human colon cancer.
CONCLUSION: The results provide evidence that cripto siRNA could be an effective approach for the inhibition of cancer cell invasion and migration and thus has potential for use in devising novel preventive and therapeutic strategies for colon cancer metastasis. PMID: 24379580 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2013 Category: Gastroenterology Authors: Jiang PC, Zhu L, Fan Y, Zhao HL Tags: World J Gastroenterol Source Type: research

Macrophage migration inhibitory factor as a potential prognostic factor in gastric cancer.
CONCLUSION: MIF could be of prognostic value in gastric cancer and might be a potential target for small-molecule therapy. PMID: 26379396 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 14, 2015 Category: Gastroenterology Authors: He LJ, Xie D, Hu PJ, Liao YJ, Deng HX, Kung HF, Zhu SL Tags: World J Gastroenterol Source Type: research

Role of mast cell-miR-490-5p in irritable bowel syndrome.
CONCLUSION: miR-490-5p plays a vital role in the pathogenesis of irritable bowel syndrome by affecting mast cell proliferation and apoptosis; with down-regulation of miR-490-5p, the mRNA level of mast cell tryptase and PAR-2 increased, and the protein level increased, but the difference was not statistically significant. PMID: 28104984 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 6, 2017 Category: Gastroenterology Authors: Ren HX, Zhang FC, Luo HS, Zhang G, Liang LX Tags: World J Gastroenterol Source Type: research

Interference of suppressor of cytokine signaling 3 promotes epithelial-mesenchymal transition in MHCC97H cells.
CONCLUSION: SOCS3 silencing is able to promote EMT in MHCC97H cells via changing the phenotypic characteristics and modulating the characteristic markers. PMID: 23430705 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 14, 2013 Category: Gastroenterology Authors: Ji YY, Wang ZD, Li ZF, Li K Tags: World J Gastroenterol Source Type: research

Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines.
CONCLUSION: To summarize, basal chemokine gene expression for pro-angiogenic chemokines was high in mutated as compared to wild type cell-lines. This reflects the likely existence of a different microenvironment in tumours consistent of wild type or mutated cells. This may help to rationalize the choice of molecular targets for suitable therapeutic investigation in clinical studies. PMID: 24659889 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - March 21, 2014 Category: Gastroenterology Authors: Khan S, Cameron S, Blaschke M, Moriconi F, Naz N, Amanzada A, Ramadori G, Malik IA Tags: World J Gastroenterol Source Type: research

Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the 5(th) most common malignancy which is responsible for more than half million annual mortalities; also, it is the third leading cause of cancer related death. Unfavorable systemic side-effects of chemotherapeutic agents and susceptibility to the degradation of small interfering RNAs (siRNAs), which can knock down a specific gene involved in the disease, have hampered their clinical application. So, it could be beneficial to develop an efficient carrier for the stabilization and specific delivery of drugs and siRNA to cells. Targeted nanoparticles have gained considerab...
Source: World Journal of Gastroenterology : WJG - November 14, 2015 Category: Gastroenterology Authors: Varshosaz J, Farzan M Tags: World J Gastroenterol Source Type: research

Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer.
CONCLUSION: MTH-1 expression in CRC cells was upregulated via HIF-1α in response to hypoxic stress, emphasizing the crucial role of HIF-1α-induced MTH-1 in tumor growth. PMID: 26730155 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 28, 2015 Category: Gastroenterology Authors: Qiu Y, Zheng H, Sun LH, Peng K, Xiao WD, Yang H Tags: World J Gastroenterol Source Type: research

Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma < em > via < /em > the PI3K/AKT pathway
CONCLUSION: Our study suggests for the first time that DDX51 promotes cancer cell proliferation by regulating the PI3K/AKT pathway; thus, DDX51 might be a therapeutic target for ESCC.PMID:35125830 | PMC:PMC8790558 | DOI:10.3748/wjg.v28.i4.464
Source: World Journal of Gastroenterology : WJG - February 7, 2022 Category: Gastroenterology Authors: Dong-Xin Hu Qi-Feng Sun Lin Xu Hong-Da Lu Fan Zhang Zhen-Miao Li Ming-Yan Zhang Source Type: research