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Source: World Journal of Gastroenterology : WJG
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Total 125 results found since Jan 2013.
Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease
CONCLUSION: FGL1 can induce intestinal inflammation by activating the canonical NF-κB signalling pathway, and it may be considered a potential biomarker and therapeutic target for CD.PMID:34629811 | PMC:PMC8475002 | DOI:10.3748/wjg.v27.i35.5946
Source: World Journal of Gastroenterology : WJG - October 11, 2021 Category: Gastroenterology Authors: Xue-Liang Sun Li-Chao Qiao Jing Gong Ke Wen Zhi-Zhong Xu Bo-Lin Yang Source Type: research
Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma.
CONCLUSION: This study shows a novel connection between YAP-1 and the UPR through the c-Myc pathway during oxidative stress in HCC. The ROS-induced activation of YAP-1 via the c-Myc pathway, which leads to the activation of the UPR pathway, might be a therapeutic target in HCC.
PMID: 33268949 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 14, 2020 Category: Gastroenterology Authors: Cho Y, Park MJ, Kim K, Kim SW, Kim W, Oh S, Lee JH Tags: World J Gastroenterol Source Type: research
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPAR α.
CONCLUSION: Folic acid improves hepatic lipid metabolism by upregulating PPARα levels via a SIRT1-dependent mechanism and restores hepatic one-carbon metabolism and diversity of gut microbiota, thereby attenuating HFD-induced NASH in rats.
PMID: 32476787 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 13, 2020 Category: Gastroenterology Authors: Xin FZ, Zhao ZH, Zhang RN, Pan Q, Gong ZZ, Sun C, Fan JG Tags: World J Gastroenterol Source Type: research
Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy.
CONCLUSION: Rpph1 is highly expressed in esophageal cancer. Silencing Rpph1 expression can promote cell apoptosis, inhibit cell proliferation and migration, and increase radio-sensitivity.
PMID: 32351293 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 20, 2020 Category: Gastroenterology Authors: Li ZY, Li HF, Zhang YY, Zhang XL, Wang B, Liu JT Tags: World J Gastroenterol Source Type: research
Long non-coding RNA HULC as a diagnostic and prognostic marker of pancreatic cancer.
CONCLUSION: HULC is an effective marker for the diagnosis and prognosis of pancreatic cancer, which may affect the biological function of pancreatic cancer cells through the Wnt/β-catenin signaling pathway.
PMID: 31857775 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 13, 2019 Category: Gastroenterology Authors: Ou ZL, Luo Z, Lu YB Tags: World J Gastroenterol Source Type: research
High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition.
CONCLUSION: The functional inhibition between Parp1 and Sirt1 leads to HMGB1 hyperacetylation, which leads to its translocation from the nucleus to the cytoplasm and finally outside the cell.
PMID: 31576091 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 27, 2019 Category: Gastroenterology Authors: Ye TJ, Lu YL, Yan XF, Hu XD, Wang XL Tags: World J Gastroenterol Source Type: research
Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.
CONCLUSION: Overall, our data demonstrate the oncogenic role of circPIP5K1A-miR-1273a axis in regulation of colon cancer development, which provides a novel insights into colon cancer pathogenesis.
PMID: 31558874 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 20, 2019 Category: Gastroenterology Authors: Zhang Q, Zhang C, Ma JX, Ren H, Sun Y, Xu JZ Tags: World J Gastroenterol Source Type: research
Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF- κB signaling pathways.
CONCLUSION: AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-κB pathway. Therefore, AITC is a potential therapeutic agent for NAFLD.
PMID: 31558861 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 13, 2019 Category: Gastroenterology Authors: Li CX, Gao JG, Wan XY, Chen Y, Xu CF, Feng ZM, Zeng H, Lin YM, Ma H, Xu P, Yu CH, Li YM Tags: World J Gastroenterol Source Type: research
Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor- κB signaling pathway.
CONCLUSION: NLRC5 may play a key role in the development and reversal of hepatic fibrosis through the NF-κB signaling pathway, and it is expected to be one of the clinical therapeutic targets.
PMID: 31293340 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - June 27, 2019 Category: Gastroenterology Authors: Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, Gao B Tags: World J Gastroenterol Source Type: research
Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury.
CONCLUSION: USP22 is correlated with promoting intestinal cell proliferation and accelerating intestinal tissue regeneration after intestinal I/R injury and may serve as a potential target for therapeutic development for tissue repair during intestinal I/R injury.
PMID: 30809082 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 21, 2019 Category: Gastroenterology Authors: Ji AL, Li T, Zu G, Feng DC, Li Y, Wang GZ, Yao JH, Tian XF Tags: World J Gastroenterol Source Type: research
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
CONCLUSION: HuR mediated overexpression of IAP1 significantly correlates with poor outcomes and early progression of pancreatic cancer. Further studies are needed to assess the underlying mechanisms.
PMID: 30670910 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 14, 2019 Category: Gastroenterology Authors: Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z Tags: World J Gastroenterol Source Type: research
