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Source: Neurochemical Research
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Total 105 results found since Jan 2013.
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Neurochemical Research - September 13, 2023 Category: Neuroscience Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment
Neurochem Res. 2023 Aug 18. doi: 10.1007/s11064-023-04011-w. Online ahead of print.ABSTRACTEvidence demonstrates that DNA methylation is associated with the occurrence and development of various neurological diseases. However, the potential target genes undergoing DNA methylation, as well as their involvement in the chemotherapy drug oxaliplatin-induced neuropathic pain, are still unclear. Here, Lrfn4, which showed hypermethylation in the promoter regions, was screened from the SRA methylation database (PRJNA587622) following oxaliplatin treatment. MeDIP and qPCR assays identified that oxaliplatin treatment increased the m...
Source: Neurochemical Research - August 17, 2023 Category: Neuroscience Authors: Yan-Hui Gu Jing Wang Wei-Cheng Lu Yong Cheng Rong Tao Shi-Jia Zhang Ting Xu Ke-Wei Zhai Su-Xia Luo Wen-Jun Xin Source Type: research
Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research
Sel1l May Contributes to the Determinants of Neuronal Lineage and Neuronal Maturation Regardless of Hrd1 via Atf6-Sel1l Signaling
Neurochem Res. 2022 Sep 8. doi: 10.1007/s11064-022-03750-6. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER) is the primary site of intracellular quality control involved in the recognition and degradation of unfolded proteins. A variety of stresses, including hypoxia and glucose starvation, can lead to accumulation of unfolded proteins triggering the ER-associated degradation (ERAD) pathway. Suppressor Enhancer Lin12/Notch1 Like (Sel1l) acts as a "gate keeper" in the quality control of de novo synthesized proteins and complexes with the ubiquitin ligase Hrd1 in the ER membrane. We previously demonstrated that ...
Source: Neurochemical Research - September 8, 2022 Category: Neuroscience Authors: Ryo Saito Seisuke Mimori Yasunobu Okuma Koichi Kawada Source Type: research
Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage
This study aimed to explore the mechanism by which miR-410 transferred by bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) may alleviate hypoxic-ischemic brain damage (HIBD) in newborn mice. BMSCs were isolated from total bone marrow cells of femur and tibia of newborn mice, and primary neurons were extracted from the cerebral cortex of newborn mice within 24 h of birth. EVs were extracted from BMSCs transfected with the mimic or inhibitor of miR-410. Primary neurons were subjected to hypoxia and treated with overexpression (oe)-HDAC4, small interfering RNA (siRNA)-β-catenin, or Wnt path...
Source: Neurochemical Research - August 26, 2022 Category: Neuroscience Authors: Mingqi Shen Rongxiu Zheng Xuan Kan Source Type: research
The protective effect of Palmatine on depressive like behavior by modulating microglia polarization in LPS-induced mice
In conclusion, this research demonstrated that Palmatine attenuated depressive like behavior by modulating microglia polarization via PDE4B/KLF4 signaling.PMID:35917005 | DOI:10.1007/s11064-022-03672-3
Source: Neurochemical Research - August 2, 2022 Category: Neuroscience Authors: Lei Wang Min Li Cuiping Zhu Aiping Qin Jinchun Wang Xianni Wei Source Type: research
