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Source: Neurochemical Research
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Total 105 results found since Jan 2013.
Epigallocatechin Gallate Alleviates Down-Regulation of Thioredoxin in Ischemic Brain Damage and Glutamate-Exposed Neuron
This study was designed to investigate the regulation of thioredoxin by EGCG in ischemic brain damage. Middle cerebral artery occlusion (MCAO) was performed to induce focal cerebral ischemia in male Sprague-Dawley rats. The EGCG (50 mg/kg) or was administered before MCAO surgical operation. Neurological behavior test, reactive oxygen species (ROS), and lipid peroxidation (LPO) measurement were performed 24 h after MCAO. The cerebral cortex was isolated for further experiments. EGCG alleviated MCAO-induced neurological deficits and increases in ROS and LPO levels. EGCG also ameliorated the decrease in thioredoxin expression...
Source: Neurochemical Research - July 30, 2021 Category: Neuroscience Authors: Dong-Ju Park Ju-Bin Kang Murad-Ali Shah Phil-Ok Koh Source Type: research
Neuroprotective Effects of Rhynchophylline Against A β < sub > 1-42 < /sub > -Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2-ARE Activation
Neurochem Res. 2021 Jun 25. doi: 10.1007/s11064-021-03343-9. Online ahead of print.ABSTRACTExtensive studies have shown that oxidative stress is a crucial pathogenic factor in Alzheimer's disease (AD). Nuclear factor E2-related factor 2 (Nrf2) is a master cytoprotective regulator against oxidative stress, and thus represents an attractive therapeutic target in AD. The goal of our study is to investigate the contribution of Nrf2 in Rhynchophylline (Rhy)-induced neuroprotection in AD. The data showed that intraperitoneal administration of Rhy (10 or 20 mg/kg) could ameliorate Aβ1-42-induced cognitive impairment, evidenced b...
Source: Neurochemical Research - June 25, 2021 Category: Neuroscience Authors: Pan Jiang Lei Chen Jian Xu Wenyuan Liu Feng Feng Wei Qu Source Type: research
ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment
In conclusion, these results suggested that the ZEB1 recruited DNMT3b to the Ddr1 promoter, which induced the DDR1 downregulation and contributed to the oxaliplatin-induced chronic pain.PMID:34032956 | DOI:10.1007/s11064-021-03355-5
Source: Neurochemical Research - May 25, 2021 Category: Neuroscience Authors: Yi-Ying Chen Kai-Sheng Jiang Xiao-Hui Bai Meng Liu Su-Yan Lin Ting Xu Jia-You Wei Dai Li Yuan-Chang Xiong Wen-Jun Xin Zhen-Yu Li Source Type: research
TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage
Neurochem Res. 2021 May 10. doi: 10.1007/s11064-021-03318-w. Online ahead of print.ABSTRACTReportedly, TWIK-related spinal cord K+ (TRESK) deficiency in spinal cord neurons positively correlates with the mechanism underlying neuropathic pain (NP). However, the precise effects of TRESK on neurons of the spinal cord remain elusive. In the present study, we investigated the impact of TRESK silencing on spinal cord neurons to further elucidate the downstream mechanisms of TRESK. Herein, neurons of the dorsal spinal cord were cultured as a cell model for investigations. Apoptosis, oxidative stress, and DNA damage-related protei...
Source: Neurochemical Research - May 11, 2021 Category: Neuroscience Authors: Pei Liu Ye Cheng Huiling Xu Haicheng Huang Simin Tang Fuhu Song Jun Zhou Source Type: research
Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway
In this study, mouse hippocampal HT-22 cells were treated with ferric ammonium citrate (FAC) alone or together with IRN, and we found IRN reduced the FAC-induced cell damage. Then, cells were treated with IRN following treatment with FAC after transfection with miR-122-5p inhibitor, and the results showed IRN reduced the FAC-induced decrease of miR-122-5p levels and relieved the ferroptosis by detecting ferroptotic marker proteins, iron ion concentration and oxidative stress level; after transfection with miR-122-5p inhibitor, the protective effects of IRN against FAC-induced ferroptosis in these cells were weakened. TP53 ...
Source: Neurochemical Research - May 4, 2021 Category: Neuroscience Authors: Haikang Zhao Xiaoqiang Li Lei Yang Liang Zhang Xiaobing Jiang Wenwen Gao Peng Chen Yingying Cheng Fenglu Wang Jianrong Liu Source Type: research
Intrathecal Injection of GRIP-siRNA Reduces Postoperative Synaptic Abundance of Kainate Receptor GluK2 Subunits in Rat Dorsal Horns and Pain Hypersensitivity
Neurochem Res. 2021 Apr 13. doi: 10.1007/s11064-021-03323-z. Online ahead of print.ABSTRACTThe mechanisms underlying postoperative pain differ from the inflammatory or neuropathic pain. Previous studies have demonstrated that intrathecal α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) -kainate (KA) receptor antagonist inhibits the guarding pain behavior and mechanical hyperalgesia, indicating a critical role of spinal KA receptors in postoperative pain hypersensitivity. However, how the functional regulations of spinal KA receptor subunits are involved in the postoperative pain hypersensitivity remains elusive. Th...
Source: Neurochemical Research - April 13, 2021 Category: Neuroscience Authors: Ruijuan Guo Huili Li Rong Shi Yun Wang Source Type: research
Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor
Neurochem Res. 2021 Apr 5. doi: 10.1007/s11064-021-03303-3. Online ahead of print.ABSTRACTNeuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in metabolism diseases. However, little research has been focused on the effect of GAA in neuroinflammation and the related mechanism. In the present study, lipopolysaccharide(LPS)-stimulated BV2 microglial cells were used to eva...
Source: Neurochemical Research - April 6, 2021 Category: Neuroscience Authors: Yue Jia Dandan Zhang Hua Yin Haoran Li Jing Du Hongkun Bao Source Type: research
Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway
Neurochem Res. 2021 Mar 13. doi: 10.1007/s11064-021-03278-1. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is accompanied by nucleus pulposus (NP) cell apoptosis, inflammation, and extracellular matrix degradation. Tumour necrosis factor receptor 1 (TNFR1) is a receptor of TNF-α, and is deeply involved in the processes of IDD. However, the effect of TNFR1 inhibition on IDD is not clear. Herein, we report that TNFR1 was increased in LPS-treated HNPCs. The aim of this study was to investigate the potential therapeutic effect of TNFR1 siRNA and selective antagonists of TNFR1 (GSK1995057) on HNPC damage...
Source: Neurochemical Research - March 13, 2021 Category: Neuroscience Authors: Feng Lv Longbiao Yang Jianxiu Wang Zhixiang Chen Qizhao Sun Peiguo Zhang Chentong Guan Yanbin Liu Source Type: research
