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Source: Neurochemical Research

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Total 105 results found since Jan 2013.

Intrathecal Injection of GRIP-siRNA Reduces Postoperative Synaptic Abundance of Kainate Receptor GluK2 Subunits in Rat Dorsal Horns and Pain Hypersensitivity
Neurochem Res. 2021 Apr 13. doi: 10.1007/s11064-021-03323-z. Online ahead of print.ABSTRACTThe mechanisms underlying postoperative pain differ from the inflammatory or neuropathic pain. Previous studies have demonstrated that intrathecal α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) -kainate (KA) receptor antagonist inhibits the guarding pain behavior and mechanical hyperalgesia, indicating a critical role of spinal KA receptors in postoperative pain hypersensitivity. However, how the functional regulations of spinal KA receptor subunits are involved in the postoperative pain hypersensitivity remains elusive. Th...
Source: Neurochemical Research - April 13, 2021 Category: Neuroscience Authors: Ruijuan Guo Huili Li Rong Shi Yun Wang Source Type: research

Inhibition of Retinal Ganglion Cell Axonal Outgrowth Through the Amino-Nogo-A Signaling Pathway.
Abstract Nogo-A is a myelin-derived inhibitor playing a pivotal role in the prevention of axonal regeneration. A functional domain of Nogo-A, Amino-Nogo, exerts an inhibitory effect on axonal regeneration, although the mechanism is unclear. The present study investigated the role of the Amino-Nogo-integrin signaling pathway in primary retinal ganglion cells (RGCs) with respect to axonal outgrowth, which is required for axonal regeneration. Immunohistochemistry showed that integrin αv, integrin α5 and FAK were widely expressed in the visual system. Thy-1 and GAP-43 immunofluorescence showed that axonal outgrowth ...
Source: Neurochemical Research - April 12, 2013 Category: Neuroscience Authors: Huo Y, Yin XL, Ji SX, Zou H, Lang M, Zheng Z, Cai XF, Liu W, Chen CL, Zhou YG, Yuan RD, Ye J Tags: Neurochem Res Source Type: research

Cdc42 Promotes Schwann Cell Proliferation and Migration Through Wnt/ β-Catenin and p38 MAPK Signaling Pathway After Sciatic Nerve Injury.
Cdc42 Promotes Schwann Cell Proliferation and Migration Through Wnt/β-Catenin and p38 MAPK Signaling Pathway After Sciatic Nerve Injury. Neurochem Res. 2017 Jan 17;: Authors: Han B, Zhao JY, Wang WT, Li ZW, He AP, Song XY Abstract Schwann cells (SCs) are unique glial cells in the peripheral nerve and may secrete multiple neurotrophic factors, adhesion molecules, extracellular matrix molecules to form the microenvironment of peripheral nerve regeneration, guiding and supporting nerve proliferation and migration. Cdc42 plays an important regulatory role in dynamic changes of the cytoskeleton. However, ...
Source: Neurochemical Research - January 16, 2017 Category: Neuroscience Authors: Han B, Zhao JY, Wang WT, Li ZW, He AP, Song XY Tags: Neurochem Res Source Type: research

Unconventional Myosin ID is Involved in Remyelination After Cuprizone-Induced Demyelination.
Abstract Myelin, which is a multilamellar structure that sheathes the axon, is essential for normal neuronal function. In the central nervous system (CNS), myelin is produced by oligodendrocytes (OLs), which wrap their plasma membrane around axons. The dynamic membrane trafficking system, which relies on motor proteins, is required for myelin formation and maintenance. Previously, we reported that myosin ID (Myo1d) is distributed in rat CNS myelin and is especially enriched in the outer and inner cytoplasm-containing loops. Further, small interfering RNA (siRNA) treatment highlighted the involvement of Myo1d in th...
Source: Neurochemical Research - October 6, 2017 Category: Neuroscience Authors: Yamazaki R, Baba H, Yamaguchi Y Tags: Neurochem Res Source Type: research

Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway
Neurochem Res. 2021 Mar 13. doi: 10.1007/s11064-021-03278-1. Online ahead of print.ABSTRACTIntervertebral disc degeneration (IDD) is accompanied by nucleus pulposus (NP) cell apoptosis, inflammation, and extracellular matrix degradation. Tumour necrosis factor receptor 1 (TNFR1) is a receptor of TNF-α, and is deeply involved in the processes of IDD. However, the effect of TNFR1 inhibition on IDD is not clear. Herein, we report that TNFR1 was increased in LPS-treated HNPCs. The aim of this study was to investigate the potential therapeutic effect of TNFR1 siRNA and selective antagonists of TNFR1 (GSK1995057) on HNPC damage...
Source: Neurochemical Research - March 13, 2021 Category: Neuroscience Authors: Feng Lv Longbiao Yang Jianxiu Wang Zhixiang Chen Qizhao Sun Peiguo Zhang Chentong Guan Yanbin Liu Source Type: research

POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment
Neurochem Res. 2023 Aug 18. doi: 10.1007/s11064-023-04011-w. Online ahead of print.ABSTRACTEvidence demonstrates that DNA methylation is associated with the occurrence and development of various neurological diseases. However, the potential target genes undergoing DNA methylation, as well as their involvement in the chemotherapy drug oxaliplatin-induced neuropathic pain, are still unclear. Here, Lrfn4, which showed hypermethylation in the promoter regions, was screened from the SRA methylation database (PRJNA587622) following oxaliplatin treatment. MeDIP and qPCR assays identified that oxaliplatin treatment increased the m...
Source: Neurochemical Research - August 17, 2023 Category: Neuroscience Authors: Yan-Hui Gu Jing Wang Wei-Cheng Lu Yong Cheng Rong Tao Shi-Jia Zhang Ting Xu Ke-Wei Zhai Su-Xia Luo Wen-Jun Xin Source Type: research

Ephrin/Ephrin Receptor Expression in Ammonia-Treated Rat Astrocytes and in Human Cerebral Cortex in Hepatic Encephalopathy.
Abstract Hepatic encephalopathy (HE) represents a neuropsychiatric syndrome, which evolves as a consequence of a low grade cerebral edema and a concomitant oxidative/nitrosative stress response. Ephrin receptors (EphR) and their ligands (ephrins) regulate astrocytic glutamate uptake and gliotransmitter release thereby governing neurotransmission, but their role in HE and ammonia toxicity is unclear. We therefore tested effects of ammonia on expression levels of EphR/ephrin isoforms in cultured rat astrocytes and analysed underlying mechanisms. NH4Cl induced mRNA expression changes of several EphR/ephrin isoforms i...
Source: Neurochemical Research - July 27, 2014 Category: Neuroscience Authors: Sobczyk K, Jördens MS, Karababa A, Görg B, Häussinger D Tags: Neurochem Res Source Type: research

Erythropoietin Attenuates Advanced Glycation Endproducts-Induced Toxicity of Schwann Cells In Vitro.
Abstract Advanced glycation endproducts (AGEs)-induced cytotoxicity is regarded as one of the main mechanisms responsible for neurological disorders. Although erythropoietin (EPO) is demonstrated to have neuroprotective effects in neurodegenerative diseases, the effects of EPO on AGEs-induced toxicity of Schwann cells (SCs) remain open for investigation. Primary cultured SCs isolated from 4 day-old Wistar rats were exposed to AGEs with or without EPO treatment for 5 days. AGEs decreased cell viability, increased apoptotic rate, elevated intracellular reactive oxygen species levels, and reduced total glutathione ...
Source: Neurochemical Research - January 14, 2015 Category: Neuroscience Authors: Yu T, Li L, Chen T, Liu Z, Liu H, Li Z Tags: Neurochem Res Source Type: research

Epigenetic Regulation of Dopamine Transporter mRNA Expression in Human Neuroblastoma Cells.
Abstract The dopamine transporter (DAT) is a key regulator of dopaminergic neurotransmission. As such, proper regulation of DAT expression is important to maintain homeostasis, and disruption of DAT expression can lead to neurobehavioral dysfunction. Based on genomic features within the promoter of the DAT gene, there is potential for DAT expression to be regulated through epigenetic mechanisms, including DNA methylation and histone acetylation. However, the relative contribution of these mechanisms to DAT expression has not been empirically determined. Using pharmacologic and genetic approaches, we demonstrate th...
Source: Neurochemical Research - May 12, 2015 Category: Neuroscience Authors: Green AL, Hossain MM, Tee SC, Zarbl H, Guo GL, Richardson JR Tags: Neurochem Res Source Type: research

Knockdown of Heat Shock Proteins HSPA6 (Hsp70B') and HSPA1A (Hsp70-1) Sensitizes Differentiated Human Neuronal Cells to Cellular Stress.
Abstract Heat shock proteins are involved in cellular repair and protective mechanisms that counter characteristic features of neurodegenerative diseases such as protein misfolding and aggregation. The HSPA (Hsp70) multigene family includes the widely studied HSPA1A (Hsp70-1) and the little studied HSPA6 (Hsp70B') which is present in the human genome and not in mouse and rat. The effect of knockdown of HSPA6 and HSPA1A expression was examined in relation to the ability of differentiated human SH-SY5Y neuronal cells to tolerate thermal stress. Low dose co-application of celastrol and arimoclomol, which induces Hsps...
Source: Neurochemical Research - October 31, 2017 Category: Neuroscience Authors: Deane CAS, Brown IR Tags: Neurochem Res Source Type: research

Interleukin-1 Receptor Associated Kinase 1 Mediates the Maintenance of Neuropathic Pain after Chronic Constriction Injury in Rats.
Abstract Neuropathic pain (NP) has complicated pathogenesis as it mainly involves a lesion or dysfunction of the somatosensory nervous system and its clinical treatment remains challenging. Chronic constriction injury (CCI) model is a widely used neuropathic pain model and involved in mechanisms including both nerve inflammatory and injury. Cytokines and their receptors play essential roles in the occurrence and persistence of neuropathic pain, but the underlying mechanisms have not well been understood. Therefore, Interleukin-1 receptor-associated kinase 1 (IRAK1) is chosen to explore the possible mechanisms of N...
Source: Neurochemical Research - March 10, 2019 Category: Neuroscience Authors: Yin D, Chen Y, Li Y, Lu R, Wang B, Zhu S, Fan B, Xu Z Tags: Neurochem Res Source Type: research