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Source: Endocrinology
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Total 87 results found since Jan 2013.
STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
CONCLUSIONS: Our study demonstrates the critical roles of STRA6 contributing to TC progression via the ILK/AKT/mTOR axis, which may provide a novel prognostic marker as well as a promising therapeutic target for aggressive TC.PMID:36592123 | DOI:10.1210/endocr/bqac215
Source: Endocrinology - January 2, 2023 Category: Endocrinology Authors: Weiman He Zhen Cheng Zijun Huo Bo Lin Xuejie Wang Yijia Sun Shuang Yu Siting Cao Junyu Xue Rengyun Liu Weiming Lv Yanbing Li Shubin Hong Haipeng Xiao Source Type: research
Laminin- α4 negatively regulates adipocyte beiging through the suppression of AMPKα in male mice
Endocrinology. 2022 Sep 19:bqac154. doi: 10.1210/endocr/bqac154. Online ahead of print.ABSTRACTLaminin-α4 (LAMA4) is an extracellular matrix protein implicated in the regulation of adipocyte differentiation and function. Prior research describes a role for LAMA4 in modulating adipocyte thermogenesis and uncoupling protein-1 (UCP1) expression in white adipose; however, the mechanisms involved are poorly understood. Here, we describe that Lama4 knockout mice (Lama4-/-) exhibit heightened mitochondrial biogenesis and peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) expression in subcutaneous white adipo...
Source: Endocrinology - September 20, 2022 Category: Endocrinology Authors: Anna Goddi Alanis Carmona Soo Young Park Gokhan Dalgin Maria A Gonzalez Porras Eric M Brey Ronald N Cohen Source Type: research
Functions of Membrane Progesterone Receptors (mPRs, PAQRs) in Nonreproductive Tissues
Endocrinology. 2022 Aug 30:bqac147. doi: 10.1210/endocr/bqac147. Online ahead of print.ABSTRACTGender differences in a wide variety of physiological parameters have implicated the ovarian hormones, estrogens and progesterone, in the regulation of numerous nonreproductive tissue functions. Rapid, nongenomic (nonclassical) progesterone actions mediated by membrane progesterone receptors (mPRs), which belong to the progestin and AdipoQ receptor (PAQR) family, have been extensively investigated in reproductive and nonreproductive tissues since their discovery in fish ovaries 20 years ago. The five mPR subtypes (α, β, γ, δ,...
Source: Endocrinology - August 30, 2022 Category: Endocrinology Authors: Peter Thomas Yefei Pang Maria Andrea Camilletti Luca F Castelnovo Source Type: research
MARK2 and MARK4 regulate Sertoli cell BTB dynamics through microtubule and actin cytoskeletons
Endocrinology. 2022 Aug 12:bqac130. doi: 10.1210/endocr/bqac130. Online ahead of print.ABSTRACTMARKs (microtubule affinity-regulating kinases) are non-receptor Ser/Thr protein kinases known to regulate cell polarity and microtubule dynamics in C. elegans, Drosophila, invertebrates, vertebrates and mammals. An earlier study has shown that MARK4 is present at the ectoplasmic specialization (EC) and blood-testis barrier (BTB) in the seminiferous epithelium of adult rat testes. Here, we report the function of MARK4 and another isoform MARK2 in Sertoli cells at the BTB. Knockdown of MARK2, MARK4 or MARK2 and MARK4 by RNAi using...
Source: Endocrinology - August 16, 2022 Category: Endocrinology Authors: Elizabeth I Tang C Yan Cheng Source Type: research
PCP protein inversin regulates testis function through changes in cytoskeletal organization of actin and microtubules
Endocrinology. 2022 Feb 1:bqac009. doi: 10.1210/endocr/bqac009. Online ahead of print.ABSTRACTInversin is an integrated component of the Frizzled (Fzd)/Dishevelled (Dvl)/Diversin planar cell polarity (PCP) complex that is known to work in concert with the Van Gogh-like protein (e.g., Vangl2)/Prickle PCP complex to support tissue and organ development including the brain, kidney, pancreas and others. However, with the exception of Dvl3 and Vangl2, other PCP proteins have not been investigated in the testis. Herein, we used the technique of RNAi to examine the role of inversin (Invs) in Sertoli cell and testis function by co...
Source: Endocrinology - February 2, 2022 Category: Endocrinology Authors: Linxi Li Sheng Gao Lingling Wang Tiao Bu Jinjin Chu Lixiu Lv Anam Tahir Baiping Mao Huitao Li Xiaoheng Li Yiyan Wang Xiaolong Wu Renshan Ge C Yan Cheng Source Type: research
