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Source: Endocrinology
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Total 87 results found since Jan 2013.
PCP protein inversin regulates testis function through changes in cytoskeletal organization of actin and microtubules
Endocrinology. 2022 Feb 1:bqac009. doi: 10.1210/endocr/bqac009. Online ahead of print.ABSTRACTInversin is an integrated component of the Frizzled (Fzd)/Dishevelled (Dvl)/Diversin planar cell polarity (PCP) complex that is known to work in concert with the Van Gogh-like protein (e.g., Vangl2)/Prickle PCP complex to support tissue and organ development including the brain, kidney, pancreas and others. However, with the exception of Dvl3 and Vangl2, other PCP proteins have not been investigated in the testis. Herein, we used the technique of RNAi to examine the role of inversin (Invs) in Sertoli cell and testis function by co...
Source: Endocrinology - February 2, 2022 Category: Endocrinology Authors: Linxi Li Sheng Gao Lingling Wang Tiao Bu Jinjin Chu Lixiu Lv Anam Tahir Baiping Mao Huitao Li Xiaoheng Li Yiyan Wang Xiaolong Wu Renshan Ge C Yan Cheng Source Type: research
Long Noncoding RNA MIAT Modulates the Extracellular Matrix Deposition in Leiomyomas by Sponging MiR-29 Family
The objective of this study was to determine the expression and functional role of a long noncoding RNA (lncRNA) MIAT (myocardial infarction associated transcript) in leiomyoma pathogenesis. Leiomyoma as compared with myometrium (N=66) expressed significantly more MIAT which was independent of race/ethnicity and menstrual cycle phase but dependent on MED12 (mediator complex subunit 12) mutation status. Leiomyomas bearing the MED12 mutation expressed higher levels of MIAT and lower levels of microRNA 29 family (miR-29a, -b and -c) compared with MED12 wild type leiomyomas. Using luciferase reporter activity and RNA immunopre...
Source: Endocrinology - September 7, 2021 Category: Endocrinology Authors: Tsai-Der Chuang Derek Quintanilla Drake Boos Omid Khorram Source Type: research
Mechanisms of OCT4 on 3,5,3'-tri-iodothyronine and FSH-induced granulosa cell development in female mice
Endocrinology. 2021 Aug 31:bqab183. doi: 10.1210/endocr/bqab183. Online ahead of print.ABSTRACTOctamer-binding transcription factor 4 (OCT4) regulates the pluripotency of stem cells and also plays important roles in granulosa cells growth, which is regulated by follicle-stimulating hormone (FSH). Thyroid hormone (TH) is important for the development and maturation of follicles and the maintenance of various endocrine functions. Although 3,5,3'-triiodothyronine (T3) enhances the effects of FSH on the regulation of the growth of granulosa cells and development of follicles, it is unclear whether and how TH combines with FSH ...
Source: Endocrinology - August 31, 2021 Category: Endocrinology Authors: Qiaozhi Wang Yilin Yao Xiaoshu Ma Baoqiang Fu Ningxin Li Cheng Zhang Source Type: research
LH induces de novo cholesterol biosynthesis via SREBP activation in granulosa cells during ovulation in female mice
In this study, when immature mice were treated with gonadotropins (eCG followed by hCG), eCG induced and hCG maintained the expression of SREBP-1a, -2, and SCAP granulosa cells, whereas INSIG1 expression was dramatically downregulated after hCG injection. Downregulation of INSIG1 led to generate the SREBPs active form and translocate the SREBPs active form to nuclei. Inhibition of generation of the SREBPs active form by fatostatin or Scap siRNA in both in vivo and in vitro significantly decreased the expressions of de novo cholesterol biosynthetic enzymes, cholesterol accumulation, and progesterone (P4) production compared...
Source: Endocrinology - August 25, 2021 Category: Endocrinology Authors: Tomoya Nakanishi Risa Tanaka Shingo Tonai Joo Yeon Lee Manami Yamaoka Tomoko Kawai Asako Okamoto Masayuki Shimada Yasuhisa Yamashita Source Type: research
Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-Mediated Effects on mTORC1 and mTORC2
This study clarified the molecular mechanism of Wnt5a in Sertoli cell junctions through the planar cell polarity (PCP) signaling pathway. Our findings could provide an experimental basis for the clinical diagnosis and treatment of male infertility caused by Sertoli cell junction impairment.PMID:34338758 | DOI:10.1210/endocr/bqab149
Source: Endocrinology - August 2, 2021 Category: Endocrinology Authors: Yan Fu Yuexin Wei Yu Zhou Huan Wu Yifan Hong Chunlan Long Junke Wang Yuhao Wu Shengde Wu Lianju Shen Guanghui Wei Source Type: research
Inhibition of miR-29 activity in the myeloid lineage increases response to calcitonin and trabecular bone volume in mice
Endocrinology. 2021 Jun 30:bqab135. doi: 10.1210/endocr/bqab135. Online ahead of print.ABSTRACTThe miR-29-3p family (miR-29a, miR-29b, miR-29c) of microRNAs is increased during RANKL-induced osteoclastogenesis. In vivo, activation of a miR-29-3p tough decoy inhibitor (TuD) in LysM-cre expressing cells (myeloid lineage) resulted in mice displaying enhanced trabecular and cortical bone volume, due to decreased bone resorption. Calcitonin receptor (Calcr) is a miR-29 target that negatively regulates bone resorption. CALCR was significantly increased in RANKL-treated miR-29-decoy osteoclasts, and these cells were more responsi...
Source: Endocrinology - June 30, 2021 Category: Endocrinology Authors: Bongjin Shin Henry C Hrdlicka Anne M Delany Sun-Kyeong Lee Source Type: research
An RNAi screening of clinically relevant transcription factors regulating human adipogenesis and adipocyte metabolism
CONCLUSIONS: This comprehensive RNAi screening in hASC suggests that a large proportion of WAT TFs that are impacted by metabolic conditions might be important for hyperplastic adipose tissue expansion. The screen also identified JARID2 as a novel TF essential for the development of functional adipocytes.PMID:33963396 | DOI:10.1210/endocr/bqab096
Source: Endocrinology - May 8, 2021 Category: Endocrinology Authors: Christel Bj örk Narmadha Subramanian Jianping Liu Juan Ramon Acosta Beatriz Tavira Anders B Eriksson Peter Arner Jurga Laurencikiene Source Type: research
TSH activates macrophage inflammation by G13 and G15-dependent pathways
This study investigated the G protein subtypes responsible for the pro-inflammatory effect of TSH on macrophages. qPCR showed that Gi2, Gi3, Gas, Gq, G11, G12, G13, G15 are abundantly expressed by macrophages. The contribution of different G-protein pathways to the pro-inflammatory effect was studied by the corresponding inhibitors or siRNA interference. While TSH-induced IκB phosphorylation was not inhibited by Gs inhibitor NF449, Gi inhibitor pertussis toxin, Gq or G11 siRNA, it was blocked by phospholipase C inhibitor U73122 or G15 siRNA interference. TSH-induced ERK and P38 phosphorylation was blocked by G13 but not G...
Source: Endocrinology - April 14, 2021 Category: Endocrinology Authors: Chongbo Yang Zhao He Qunye Zhang Ming Lu Jiajun Zhao Wenbin Chen Ling Gao Source Type: research
