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Source: Biology of Reproduction
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Total 100 results found since Jan 2013.
HIF-1 α is Essential for the Augmentation of Myometrial Contractility during Labor
In this study, transcriptomes revealed that hypoxia-inducible factor (HIF)-1α was up-regulated in laboring myometrial biopsies, while blockade of HIF-1α decreased the contractility of the myometrium and myocytes in vitro via siRNA and the inhibitor, 2-methoxyestradiol. Chromatin immunoprecipitation sequencing revealed that HIF-1α directly binds to the genome of contraction-associated proteins: the promoter of GJA1 and PTGS2, and the intron of OXTR. Silencing the HIF-1α reduced the expression of PTGS2, GJA1, and OXTR. Furthermore, blockade of GJA1 or PTGS2 led to a significant decrease in myometrial contractions in the ...
Source: Biology of Reproduction - September 12, 2022 Category: Reproduction Medicine Authors: Bolun Wen Zheng Zheng Lele Wang Xueya Qian Xiaodi Wang Yunshan Chen Junjie Bao Yanmin Jiang J I Kaiyuan Huishu Liu Source Type: research
Associations between isoflavone exposure and reproductive damage in adult males: evidence from human and model system studies
This study was designed to investigate whether isoflavone exposure during adulthood could have deleterious impacts on male reproductive health by the cross-sectional study, animal experiments, and in vitro tests. In the cross-sectional study, we observed that urinary isoflavones were not significantly associated with semen quality including sperm concentrations, sperm count, progressive motility, and total motility, respectively (All P-value for trend>0.05). However, negative associations were found between plasma testosterone and urinary Σisoflavones, genistein, glycitein, and dihydrodaidzein (all P-value for trend &l...
Source: Biology of Reproduction - August 10, 2022 Category: Reproduction Medicine Authors: Wang Yang Jiuyang Deng Jianfang Gao Huan Yang Qing Chen Zhou Niya Xi Ling Guowei Zhang Peng Zou Lei Sun Linping Huang Jinyi Liu Jia Cao Lin Ao Source Type: research
Activin a promotes hyaluronan production and upregulates versican expression in human granulosa cells via the ALK4-SMAD2/3-SMAD4 signaling pathway
Biol Reprod. 2022 Apr 9:ioac070. doi: 10.1093/biolre/ioac070. Online ahead of print.ABSTRACTHyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 (HAS2) is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and is critical for successful ovulation. Activin A is a critical intrafollicular regulator of ovarian function. Although activin A has been shown to promote cumulus matrix expansion in mice, the functional role of activin A in the regulation of cumulus expansion in the human ovary remains to be elucidated....
Source: Biology of Reproduction - April 11, 2022 Category: Reproduction Medicine Authors: Shen Tian Han Zhang Hsun-Ming Chang Christian Klausen He-Feng Huang Min Jin Peter C K Leung Source Type: research
The Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
Biol Reprod. 2022 Jan 29:ioac020. doi: 10.1093/biolre/ioac020. Online ahead of print.ABSTRACTAs a critical paracrine regulator of multiple reproductive functions, the cytokine interleukin-6 (IL-6) is expressed in human granulosa cells and can be detected in follicular fluid. At present, the functional role of IL-6 in the regulation of ovarian steroidogenesis is controversial. Moreover, the detailed molecular mechanisms by which IL-6 regulates the production of progesterone in human granulosa cells remain to be elucidated. In the present study, we used primary and immortalized human granulosa-lutein (hGL) cells to investiga...
Source: Biology of Reproduction - January 31, 2022 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jeremy H Wang Jing Yang Peter C K Leung Source Type: research
HOXA10 improves endometrial receptivity by upregulating E-cadherin
In conclusion, HOXA10 can bind to the E-cadherin promoter region and directly regulate its expression, thereby improving endometrial receptivity and subsequently increasing the embryo adhesion and implantation.PMID:35044439 | DOI:10.1093/biolre/ioac007
Source: Biology of Reproduction - January 19, 2022 Category: Reproduction Medicine Authors: Yin Bi Weiyu Huang Lifang Yuan Saiqiong Chen Shengbin Liao Xiaoqian Fu Bo Liu Yihua Yang Source Type: research
Myostatin increases human trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 Signaling
In this study, we tested the hypothesis that myostatin increases trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 signaling. Primary and immortalized (HTR8/SVneo) trophoblast cells were used as study models. Matrigel-coated transwell invasion assays were used to study the effects of recombinant human myostatin on trophoblast cell invasion. RT-qPCR and Western blot were used to measure myostatin effects on N-cadherin mRNA and protein levels, respectively. Small inhibitor molecules as well as siRNA-mediated knockdown were used to block myostatin receptor and downstream signaling, respectively. Data were...
Source: Biology of Reproduction - January 12, 2022 Category: Reproduction Medicine Authors: Faten AbdelHafez Ahmed Christian Klausen Hua Zhu Peter C K Leung Source Type: research
Impact of growth hormone-releasing hormone (GHRH) antagonist on Decidual stromal cell growth and apoptosis in vitro
Biol Reprod. 2021 Nov 18:ioab214. doi: 10.1093/biolre/ioab214. Online ahead of print.ABSTRACTEndometrial stromal cells remodeling is critical during human pregnancy. GHRH and its functional receptor have been shown to be expressed in gynecological cancer cells and eutopic endometrial stromal cells. Recent studies have demonstrated the potential clinical uses of antagonists of GHRH as effective antitumor agents because of its directly antagonistic effect on the locally produced GHRH in gynecological tumors. However, the impact of GHRH antagonists on normal endometrial stromal cell growth remained to be elucidated. The aim o...
Source: Biology of Reproduction - November 18, 2021 Category: Reproduction Medicine Authors: Hsien-Ming Wu Liang-Hsuan Chen Andrew V Schally Hong-Yuan Huang Yung-Kuei Soong Peter C K Leung Hsin-Shih Wang Source Type: research
