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Source: Biology of Reproduction
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Total 100 results found since Jan 2013.
The role of PGRMC2 in the trophoblast invasion
In conclusion, PGRMC2 plays a role in placentation by promoting cell proliferation, invasion, and angiogenesis in EVTs via activation of HIF1α signaling. We thus identified a new function of PGRMC2 and provide insights on understanding the mechanisms of trophoblast invasion.PMID:37665239 | DOI:10.1093/biolre/ioad109
Source: Biology of Reproduction - September 4, 2023 Category: Reproduction Medicine Authors: Tae Yokouchi-Konishi Yongjie Liu Liping Feng Source Type: research
Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation
Biol Reprod. 2023 Sep 2:ioad108. doi: 10.1093/biolre/ioad108. Online ahead of print.ABSTRACTSpexin (SPX) is a novel neuropeptide and adipokine negatively correlated with obesity and insulin resistance. A recent study investigated expression and regulatory function of SPX in the hypothalamus and pituitary; however, the effect on ovarian function is still unknown. The aim of this study was to characterize the expression of SPX and its receptors, galanin receptors 2 and 3 (GALR2/3) in the human ovary and to study its in vitro effect on granulosa cells (GC) function. Follicular fluid (FF) and GC were obtained from normal weigh...
Source: Biology of Reproduction - September 2, 2023 Category: Reproduction Medicine Authors: Patrycja Kurowska Monika Dawid Julia Oprocha Natalia Repekta Lo ïse Serra Anthony Estienne Piotr Pawlicki Ma łgorzata Kotula-Balak Fabrice Gu érif Joelle Dupont Agnieszka Rak Source Type: research
NRF2 protects against ROS-induced preterm premature rupture of membranes through regulation of mitochondria †
Biol Reprod. 2023 Jul 10:ioad075. doi: 10.1093/biolre/ioad075. Online ahead of print.ABSTRACTPreterm premature rupture of membranes (pPROM) is a major cause of preterm birth and neonatal mortality. Reactive oxygen species (ROS) have been identified as a critical factor in the development of pPROM. Mitochondria are known to be the primary source of ROS and play a vital role in maintaining cellular function. The Nuclear erythroid 2-related factor 2 (NRF2) has been demonstrated to play a crucial role in regulating mitochondrial function. However, research exploring the impact of NRF2-regulated mitochondria on pPROM is limited...
Source: Biology of Reproduction - July 10, 2023 Category: Reproduction Medicine Authors: Xinyuan Zhang Xiao He Linna Wei Yang He Yunlong Li Yingxiong Wang Chunli Li Source Type: research
USP7 prevents recurrent spontaneous abortion by targeting EZH2 to regulate trophoblast proliferation, apoptosis, migration and invasion through the Wnt/ β-catenin pathway†
In this study, we analyzed the expression of USP7 in villous tissues obtained from RSA patients and healthy controls, and then GNE-6776 (a USP7-specific inhibitor) and USP7 siRNA were used in a trophoblast cell line, HTR-8/SVneo, to further assess the effect of USP7 on the biological function of trophoblasts. Our results provide convincing evidence that USP7 is downregulated in the placental villous tissues of RSA patients. USP7 was found to have a crucial role in the proliferation, apoptosis, migration, invasion and epithelial-mesenchymal transition (EMT) process of trophoblast cells. Further experiments revealed that USP...
Source: Biology of Reproduction - May 30, 2023 Category: Reproduction Medicine Authors: Mengqi Zhou Yue Gao Shujuan Wu Jiao Chen Jinli Ding Yaqin Wang Jing Yang Source Type: research
Sialyl Lewis X mediates interleukin-1 beta induced trophoblast adhesion to endometrial cells during human embryo implantation
Biol Reprod. 2023 Jan 16:ioad007. doi: 10.1093/biolre/ioad007. Online ahead of print.ABSTRACTCell surface carbohydrate antigens sialyl Lewis X (sLeX) and Lewis Y (LeY) are paramount glycoconjugates and are abundantly expressed in the receptive endometrium. Furthermore, among the important biological functions of both antigens is their role in leukocytes adhesion and extravasation. Interleukin-1 beta (IL-1β) is involved in the process of human embryo implantation and placenta development. Here we used an in vitro model to investigate whether sLeX and LeY are playing a role in the embryo implantation process mediated by IL-...
Source: Biology of Reproduction - January 17, 2023 Category: Reproduction Medicine Authors: Zhi Ma Mirjana Kessler Anca Chelariu-Raicu Markus Sperandio Sven Mahner Udo Jeschke Viktoria von Sch önfeldt Source Type: research
