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Source: The International Journal of Biochemistry and Cell Biology
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Total 120 results found since Jan 2013.
AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression
Int J Biochem Cell Biol. 2022 Feb 24;145:106188. doi: 10.1016/j.biocel.2022.106188. Online ahead of print.ABSTRACTFascin is the main actin-bundling protein in filopodia and is highly expressed in metastatic tumor cells. The overexpression of Fascin has been associated with poor clinical prognosis and metastatic progression. Post-translational modifications of Fascin, such as phosphorylation, can affect the proliferation and invasion of tumor cells by regulating the actin-bundling activity of Fascin. However, the phosphorylation sites of Fascin and their corresponding kinases require further exploration. In the current stud...
Source: The International Journal of Biochemistry and Cell Biology - February 27, 2022 Category: Biochemistry Authors: Zhi-Da Zhang Bing Wen Da-Jia Li Dan-Xia Deng Xiao-Dong Wu Yin-Wei Cheng Lian-Di Liao Lin Long Geng Dong Li-Yan Xu En-Min Li Source Type: research
WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation
In conclusion, this study revealed that WDR62 functions in multiple ways during oocyte meiotic maturation, which could be related to p-JNK and H3K9 trimethylation.PMID:35093571 | DOI:10.1016/j.biocel.2022.106169
Source: The International Journal of Biochemistry and Cell Biology - January 30, 2022 Category: Biochemistry Authors: Yong-Sheng Wang Chao Chen Muhammad Jamil Ahmad Fan Chen Zhi-Ming Ding Sheng-Ji Yang Yang-Wu Chen Ze-Qun Duan Ming Liu Ai-Xin Liang Chang-Jiu He Guo-Hua Hua Li-Jun Huo Source Type: research
Loss of lymphocyte cytosolic protein 1 (LCP1) induces browning in 3T3-L1 adipocytes via β3-AR and the ERK-independent signaling pathway
Int J Biochem Cell Biol. 2021 Aug 6:106053. doi: 10.1016/j.biocel.2021.106053. Online ahead of print.ABSTRACTIncreased browning of white adipocytes (beiging) is considered a promising therapeutic strategy to fight obesity and its associated metabolic complications. However, the molecular mechanism modulating brown and beige fat-mediated thermogenesis is not fully elucidated. Here, we identified the lymphocyte cytosolic protein 1 (LCP1) as a factor that obstructs fat browning in white adipocytes. LCP1 plays a vital role in non-hematopoietic malignancies, and is also a well-known tumor biomarker; however, evidence regarding ...
Source: The International Journal of Biochemistry and Cell Biology - August 9, 2021 Category: Biochemistry Authors: Subramani Manigandan Jong Won Yun Source Type: research
Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
Int J Biochem Cell Biol. 2021 Jun 22:106028. doi: 10.1016/j.biocel.2021.106028. Online ahead of print.ABSTRACTAntiapoptotic and proapoptotic BCL-2 protein family members regulate mitochondrial apoptotic pathway. Small molecule inhibitors of antiapoptotic BCL-2 proteins including BCL-2-specific inhibitor ABT-199 (Venetoclax) are in clinical development. However, the efficiency of ABT-199 as a single agent in solid tumors is limited. We performed a high-throughput RNAi kinome screen targeting 691 kinases to identify potentially targetable kinases to enhance ABT-199 response in breast cancer cells. Our studies identified Wee1...
Source: The International Journal of Biochemistry and Cell Biology - June 25, 2021 Category: Biochemistry Authors: Yeliz Aka Bahriye Karakas Ufuk Acikbas Huveyda Basaga Ozgur Gul Ozgur Kutuk Source Type: research
Selective deletion of Connective Tissue Growth Factor attenuates experimentally -induced pulmonary fibrosis and pulmonary arterial hypertension
In this study, genetic manipulation of the CCN2 gene was employed to investigate the role of CCN2 expression in vitro and in experimentally-induced models of pulmonary fibrosis and pulmonary arterial hypertension (PAH). Knocking down CCN2 using siRNA, reduced expression of pro-fibrotic markers (fibronectin p < 0.01, collagen type I p < 0.05, α-SMA p < 0.0001, TIMP-1 p < 0.05 and IL-6 p < 0.05) in TGF-β-treated lung fibroblasts derived from systemic sclerosis patients. In vivo studies were performed in mice using a conditional gene deletion strategy targeting CCN2 in a fibroblast-specific and time-dependent...
Source: The International Journal of Biochemistry and Cell Biology - March 4, 2021 Category: Biochemistry Authors: Angela Y Y Tam Amy L Horwell Sarah L Trinder Korsa Khan Shiwen Xu Voon Ong Christopher P Denton Jill T Norman Alan M Holmes George Bou-Gharios David J Abraham Source Type: research
Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells.
CONCLUSIONS: Given that the lncRNA CCAT1 was found to be overexpressed in endometrial cancer, affected the growth of HEC-1B cells and the expression of growth regulatory genes, our data suggest CCAT1 to exert oncogenic functions in endometrial cancer and encourage further studies to examine to what extent this lncRNA might be a potential therapy target in this cancer entity.
PMID: 32173521 [PubMed - as supplied by publisher]
Source: The International Journal of Biochemistry and Cell Biology - March 11, 2020 Category: Biochemistry Authors: Treeck O, Skrzypczak M, Schüler-Toprak S, Weber F, Ortmann O Tags: Int J Biochem Cell Biol Source Type: research
